Herbicidal pyrimidines

ABSTRACT

Aryl and heteroaryl sulfonimidamides which also contain a pyrimidine or triazine heterocycle are useful as general or selective preemergent and postemergent herbicides.

BACKGROUND OF THE INVENTION

This invention concerns sulfonimidamide herbicides that contain apyrimidine or triazine heterocycle.

Preparation of an inactive sulfonimidamide analogue of tolbutamide isdisclosed in J. Orq. Chem. 1979, 44, 2055. Herbicidal sulfonamides areknown in the art; see, for example, U.S. Pat. No. 4,127,405 and U.S.Pat. No. 4,167,719.

SUMMARY OF THE INVENTION

This invention relates to these compounds of Formula I, agriculturallysuitable compositions containing them and their use as preemergentherbicides, postemergent herbicides, and/or plant growth regulants:##STR1## wherein

R is H or CH₃ ;

G is O or NR₁ ;

R₁ is H, C₁ to C₃ alkyl, CF₂ H, C₂ to C₃ alkyl substituted with 1 to 3atoms of F, CH₂ CH₂ OCH₃, CH₂ CH₂ OH, CH₂ CH₂ OSi(CH₃)₃, OH, OSi(CH₃)₃,C₁ to C₂ alkoxy, SO₂ CH₃, phenyl or benzyl; ##STR2##

R₂ is C₁ to C₄ alkyl, C₁ to C₄ alkoxy, OCH₂ CH₂ OCH₃, F, Cl, Br, C₁ toC₂ haloalkoxy, C₁ to C₂ haloalkylthio, C₁ to C₂ haloalkylsulfonyl, C₂ toC₃ alkylcarbonyl, NO₂, CO₂ R₁₇, SO₂ NR₁₈ R₁₉, SO₂ N(OCH₃)CH₃, OSO₂ R₂₀,S(O)_(p) R₂₁, C₃ to C₄ alkenyloxy, C₃ to C₄ alkynyloxy, C₁ to C₂ alkylsubstituted with OCH₃, OCH₂ CH₃, 1 to 3 atoms of F or Cl, or with 1 Br,C₂ to C₃ alkenyl optionally substituted with 1 to 3F or Cl, C₆ H₅,##STR3##

R₃ is H, F, Cl, Br, CF₃, CH₃, CH₂ CH₃, OCH₃, OCF₂ H, OC₂ H₅, C₁ to C₂alkylthio, CH₂ SCH₃, CH₂ OCH₃ or C₁ to C₂ alkoxy substituted with 1 to 3F;

R₄ is H, CH₃, OCH₃, F, Cl, Br, SO₂ N(CH₃)₂, OSO₂ CH₃ or SO₂ CH₃ ;

R₅ is CH₃, CH₂ CH₃, OCH₃, OCH₂ CH₃, F, Cl, Br, SO₂ NR₁₈ R₁₉, SO₂N(OCH₃)CH₃ or SO₂ R₂₁ ;

R₆ is F, Cl, Br, NO₂, CO₂ R₁₇, SO₂ NR₁₈ R₁₉, SO₂ N(OCH₃)CH₃ or SO₂ R₂₁ ;

R₇ is H or C₁ to C₄ alkyl;

R₈ is H or CH₃ ;

R₉ is H or CH₃ ;

R₁₀ is H or C₁ to C₄ alkyl;

R₁₁ is H or CH₃ ;

R₁₂ is H, C₁ to C₆ alkyl, C₂ to C₃ alkoxycarbonyl, C₂ to C₃alkylcarbonyl or C₂ to C₄ alkyl substituted with Cl, Br, OCH₃ or OC₂ H₅,or with 1 to 3F;

R₁₃ is H or C₁ to C₃ alkyl;

R₁₄ is H or CH₃ ;

R₁₅ is H or C₁ to C₃ alkyl;

R₁₆ is C₁ to C₃ alkyl, F, Cl, Br, NO₂, CO₂ R₁₇, SO₂ NR₁₈ R₁₉, SO₂N(OCH₃)CH₃, SO₂ R₂₁ or OCF₂ H;

R₁₇ is C₁ to C₄ alkyl, CH₂ CH₂ OCH₃, CH₂ CH₂ Cl or CH₂ CH═CH₂ ;

R₁₈ is C₁ to C₃ alkyl;

R₁₉ is C₁ to C₃ alkyl;

R₂₀ is C₁ to C₃ alkyl or N(CH₃)₂ ;

R₂₁ is C₁ to C₃ alkyl or CH₂ CH═CH₂ ;

m is 0 or l;

p is 0, 1 or 2;

Q₁ is O or SO₂ ;

Q₂ is O or S; ##STR4##

X is CH₃, OCH₃, OCH₂ CH₃, Cl, F, Br, I, OCF₂ H, CH₂ F, OCH₂ CH₂ F, OCH₂CHF₂, OCH₂ CF₃ or CF₃ ;

Y is H, CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, CH₂ OCH₂ CH₃, NHCH₃, N(OCH₃)CH₃,N(CH₃)₂, C₂ H₅, CF₃, SCH₃, OCH₂ C.tbd.CH, amino, CH₂ S(O)CH₃, CH₂ SO₂CH₃, C.tbd.CH, C.tbd.CCH₃, OCH₂ CH═CH₂, OCH₂ CH₂ OCH₂, CH₂ SCH₃,##STR5## SCF₂ H or cyclopropyl;

n is 2 or 3;

Q₃ and Q₄ are independently O or S;

Q₅ is O or NR₂₅ ;

R₂₂ is H or CH₃ ;

R₂₃ and R₂₄ are independently C₁ to C₂ alkyl;

R₂₅ is H or C₁ to C₃ alkyl;

R₂₆ is H or Cl;

R₂₇ is H or Cl;

R₂₈ is H or CH₃ ; Z is CH or N; Y₁ is O or CH₂ ;

X₁ is H, CH₃ or OCH₃ ;

Y₂ is H or CH₃ ;

X₂ is CH₃, C₂ H₅ or CH₂ CF₃ ;

Y₃ is OCH₃, OC₂ H₅, SCH₃, SC₂ H₅, OCF₂ H, SCF₂ H, CH₃ or C₂ H₅ ;

X₃ is CH₃ or OCH₃ ;

Y₄ is CH₃, OC₂ H₅, OCH₃ or Cl; and

X₄ is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃ or Cl;

and their agriculturally suitable salts;

provided that

(a) when X is Cl, F, Br or I, then Z is CH and Y is OCH₃, OC₂ H₅,N(OCH₃)CH₃, NHCH₃, N(CH₃)₂, OCF₂ H or amino;

(b) when m is 1, then R₉ is H;

(c) the total number of carbon atoms of R₁₈ and R₁₉ does not exceedfour;

(d) when L is L-15, then R₁₃ and R₁₄ are not simultaneously H;

(e) when X or Y is OCF₂ H, then Z is CH;

(f) when L is L-16, then R₁₆ is adjacent to the substituent ##STR6## and

(g) when the total number of carbon atoms of X and Y is greater thanfour, then R₁ is H or CH₃ or the total number of carbons of thesubstituents on L does not exceed four.

In the above definitions, the term "alkyl" used either alone or incompound words such as "alkylthio" or "haloalkyl", denotes straightchain or branched alkyl, e.g., methyl, ethyl, n-propyl, isopropyl or thedifferent butyl isomers.

Alkoxy denotes methoxy, ethoxy, n-propoxy, isopropoxy and the differentbutoxy isomers.

Alkenyl denotes straight chain or branched alkenes, e.g., vinyl,1-propenyl, 2-propenyl, 3-propenyl and the different butenyl isomers.

Alkynyl denotes straight chain or branched alkynes, e.g., ethynyl,1-propynyl, 2-propynyl and the different butynyl isomers.

The term "halogen", either alone or in compound words such as"haloalkyl", denotes fluorine, chlorine, bromine or iodine.

Alkylcarbonyl denotes acetyl or propionyl.

Alkoxycarbonyl denotes methoxy- or ethoxycarbonyl.

In terms such as C₂ to C₃ alkylthioalkyl, the specified number of carbonatoms is meant to define the total number of carbon atoms in thatsubstituent group. For example, C₂ to C₃ alkylthioalkyl would designateCH₂ SCH₃, CH₂ SC₂ H₅, CH₂ CH₂ SCH₃ or CH(CH₃)SCH₃, and C₂ to C₅alkoxyalkoxy would represent OCH₂ OCH₃ through O(CH₂)₄ OCH₃ or OCH₂O(CH₂)₃ CH₃ and the various structural isomers embraced therein.

Preferred for reasons of their higher herbicidal activity, greater plantgrowth regulant activity and/or more favorable ease of synthesis are:

(1) Compounds of Formula I where

G is O; and

R is H;

(2) Compounds of Formula I where

G is NR₁ ;

R is H; and

R₁ is H, C₁ to C₂ alkyl, CH₂ CF₃ or CF₂ H;

(3) Compounds of Preferred Group 1 where

Y is CH₃, OCH₃, CH₂ OCH₃, C₂ H₅, NHCH₃, cyclopropyl or CH(OCH₃)₂ ; and

R₁ is H, C₁ to C₂ alkyl, CH₂ CF₃ or CF₂ H;

(4) Compounds of Preferred Group 3 where

R₂ is CH₁ to C₃ alkyl, C₁ to C₃ alkoxy, Cl, Br, NO₂, CF₃, CO₂ R₁₇, SO₂N(CH₃)₂, OSO₂ R₂₀, SO₂ R₂₁, OCHF₂, ##STR7## R₃ H, Cl, CH₃ or OCH₃ ; R₄is CH₃, OCH₃, Cl, Br, OSO₂ CH₃ or SO₂ CH₃ ;

R₅ is Cl, SO₂ N(CH₃)₂ or SO₂ CH₃ ;

R₆ is Cl, NO₂, CO₂ R₁₇, SO₂ N(CH₃)₂ or SO₂ R₂₁ ;

R₇ is H or CH₃ ;

R₉ is H;

R₁₀ is H or CH₃ ;

R₁₁ is H;

R₁₂ is H or C₁ to C₄ alkyl;

R₁₃ is H or CH₃ ;

R₁₅ is CH₃ ;

R₁₆ is C₁ to C₂ alkyl, Cl, Br, NO₂, CO₂ CH₃, SO₂ N(CH₃)₂, SO₂ R₂₁ orOCF₂ H;

R₁₇ is C₁ to C₃ alkyl;

R₂₀ is C₁ to C₃ alkyl;

R₂₁ is C₁ to C₂ alkyl;

R₂₅ is H or CH₃ ;

R₂₈ is H;

Q₂ is O;

A is A-1; and

X is CH₃, OCH₃, OC₂ H₅, Cl, OCF₂ H or OCH₂ CF₃ ;

(5) Compounds of Preferred Group 4 where

L is L-1; and

R₂ is CH₃, C₂ H₅, CF₃, Br, Cl or SO₂ R₂₁ ;

(6) Compounds of Preferred Group 4 where

L is L-5; and

R₆ is Cl or SO₂ R₂₁ ;

(7) Compounds of Preferred Group 4 where L is L-7;

(8) Compounds of Preferred Group 4 where L is L-9;

(9) Compounds of Preferred Group 4 where L is L-10;

(10) Compounds of Preferred Group 4 where L is L-15;

(11) Compounds of Preferred Group 4 where

L is L-16; and

R₁₆ is C₁ to C₂ alkyl, Cl, Br or SO₂ R₂₁ ;

(12) Compounds of Preferred Group 2 where

L is L-1, L-5, L-7, L-9, L-10, L-15 or L-16;

R₂ C₁ to C₃ alkyl, C₁ to C₃ alkoxy, Cl, Br, NO₂, CF₃, CO₂ R₁₇, So₂N(CH₃)₂, OSO₂ R₂₀, SO₂ R₂₁, OCHF₂, ##STR8## R₃ is H, Cl, CH₃ or OCH₃ ;R₄ is CH₃, OCH₃, Cl, Br, OSO₂ CH₃ or SO₂ CH₃ ;

R₅ is Cl, SO₂ N(CH₃)₂ or SO₂ CH₃ ;

R₆ is Cl, NO₂, CO₂ R₁₇, SO₂ N(CH₃)₂ or SO₂ R₂₁ ;

R₇ is H or CH₃ ;

R₉ is H;

R₁₀ is H or CH₃ ;

R₁₁ is H;

R₁₂ H or C₁ to C₄ alkyl;

R₁₃ is H or CH₃ ;

R₁₅ is CH₃ ;

R₁₆ is C₁ to C₂ alkyl, Cl, Br, NO₂, CO₂ CH₃, SO₂ N(CH₃)₂, SO₂ R₂₁ orOCF₂ H;

R₁₇ is C₁ to C₃ alkyl;

R₂₀ is C₁ to C₃ alkyl;

R₂₁ is C₁ to C₂ alkyl;

R₂₅ is H or CH₃ ;

R₂₈ is H;

Q₂ is O;

A is A-1; and

X is CH₃, OCH₃, OC₂ H₅, Cl, OCF₂ H or OCH₂ CF₃ ;

Specifically preferred for reason of higher herbicidal activity and/ormore favorable ease of synthesis are:

(i)2-bromo-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-N'-methylbenzenesulfonimidamide,m.p. 120° to 125° C.;

(ii)2-chloro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-N'-methylbenzenesulfonimidamide,m.p. 154° to 160° C.; and

(iii)N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(methylsulfonyl)benzenesulfonimidamide,m.p. 135° to 145° C.(d).

DETAILED DESCRIPTION OF THE INVENTION Synthesis

The compounds of Formula I can be prepared by one or more of the methodsdescribed in Equations 1 to 4 and 16. ##STR9##

where A, L, R and R₁ are as previously defined, except that for thismethod R₁ cannot be CH₂ CH₂ OH or OH; R₂, R₆, and R₁₆ cannot be CO₂ R₁₇; and L cannot be L-10, L-13, L-14, or L-15.

Reaction of a sulfonimidamide or a sulfonodiimidamide (1) with anappropriate methylpyrimidinyl carbamate or methyltriazinyl carbamate (2)in the presence of at least an equimolar amount of trimethylaluminumleads to compounds of Formula I.

The reaction of Equation 1 is best run in either dichloromethane or1,2-dichloroethane solution at 20° to 85° C. for 10 to 96 hours under anitrogen or argon atmosphere. The product can be isolated by addition ofan aqueous acetic acid solution followed by extraction of the productinto dichloromethane, or by filtration of a product of low solubility.The product can be purified by trituration with solvents such as1-chlorobutane or ethyl ether, by recrystallization from mixtures ofsolvents such as 1,2-dichloroethane, 1-chlorobutane, and heptane, or bycolumn chromatography on silica gel.

Many of the compounds of Formula I can be prepared by the method shownin Equation 2. ##STR10## where A, L, R and R₁ are as previously defined,except that for this method R₁ cannot be CH₂ CH₂ OH or OH.

In this method a solution of compound (1) in anhydrous pyridine at -30°to 30° C. is treated with at least one equivalent of phenylchloroformate. After 1 to 8 hours the solvent is evaporated, and theresidue is taken up in a mixture of dichloromethane and water. Themixture is acidified with concentrated hydrochloric acid to pH 4, andthe dichloromethane layer is separated, and dried over sodium sulfate.Evaporation of the dichloromethane leaves carbamate (3) (Equation 2a).

Many variations on the above conditions and reagents are possible. Withcompounds (1) stable to stronger bases, mixtures of aqueous sodium orpotassium hydroxide and tetrahydrofuran or dioxane may replace thepyridine. Alternatively, mixtures of potassium carbonate intetrahydrofuran at 0° to 65° C. in the presence or absence of4-dimethylaminopyridine may replace the pyridine.

With very strong base and polar aprotic solvent combinations such assodium hydride in N,N-dimethylformamide, or lithium diisopropylamide orn-butyllithium in tetrahydrofuran or dioxane, diphenyl carbonate mayreplace the phenyl chloroformate. Of course, when strong or very strongbases are employed, at least two equivalents of the base is required,and acidification is necessary in the course of isolating carbonate (3).

The desired compounds of Formula I are prepared by contacting the phenylcarbamates of Formula (3) with equimolar amounts of the appropriateheterocyclic amines of Formula (4) in an inert solvent such as1,4-dioxane or tetrahydrofuran at 20° to 102° C. for 0.5 to 24 hours.The products can be isolated by evaporation of the reaction solvent andcan be purified by trituration with a solvent such as 1-chlorobutane orethyl ether, by recrystallization from mixtures of solvents such as1,2-dichloroethane, 1-chlorobutane, and heptane, or by columnchromatography on silica gel.

Alternatively, most of the compounds of Formula I where R is H can beprepared by the method shown in Equation 3. ##STR11## where A, L, and R₁are as previously defined, except that for this method R₁ cannot be CH₂CH₂ OH or OH.

Equimolar amounts of compound (1) and a heterocyclic phenyl carbamate(5) in a polar aprotic solvent such as acetonitrile or 1,4-dioxane at 0°to 40° C. are treated with an equimolar amount of1,8-diazabicyclo-[5.4.0]undec-7-ene (DBU) (Equation 3). Following oneprocedure, the mixture is diluted with ice-water and acidified to pH 4-5with hydrochloric or acetic acid. If the product crystallizes, it iscollected, rinsed with ice-water and dried. If it does not, the aqueoussolution is extracted with dichloromethane, and the dichloromethanesolution is dried and evaporated to provide the product of Formula I incrude form. Alternatively, the reaction mixture is evaporated, and theresidue is acidified with acetic acid to give the product of Formula Icontaminated with phenol and the acetate salt of DBU. The product I canbe purified by trituration with a solvent such as 1-chlorobutane orethyl ether, by recrystallization from mixtures of solvents such as1,2-dichloroethane, 1-chlorobutane, and heptane, or by columnchromatography on silica gel.

The phenyl carbamates (5) can be prepared by methods, or modificationsthereof known to those skilled in the art, described in South AfricanPatent Application 825671 and South African Patent Application 825045.

Many of the compounds of Formula I can be prepared by the method shownin Equation 4. ##STR12## where A, L, R, and R₁ are as previouslydefined, except that for this method R₁ cannot be CH₂ CH₂ OH or OH.

In this method compounds of Formula I are prepared by reacting compounds(6) with appropriate amino or alkylamino heterocycles (4) (Equation 4).

The reactions are best carried out in inert aprotic organic solventssuch as dichloromethane, 1,2-dichloroethane, tetrahydrofuran, oracetonitrile, at a temperature between 20° and 85° C. The order ofaddition is not critical; however, it is often convenient to add thesulfonimidoyl or sulfonodiimidoyl isocyanate or a solution of it in thereaction solvent to a stirred suspension of the amine.

Compounds (6) are generally prepared from the respective compounds (1)(see Equations 14 and 15). Occasionally a compound (1) may not besufficiently stable to be useful as an intermediate. In these cases, aswell as others, the requisite compound (6) can be reacted with theheterocyclic amine (4) by treating the corresponding sulfonimidoylchloride by sulfonodiimidoyl chloride with the isocyanate anion in thepresence of the amine (see Equation 16 and accompanying discussion.)

In some cases, the desired product is insoluble in the reaction solventat ambient temperature and crystallizes from it in pure form. Productssoluble in the reaction solvent are isolated by evaporation of thesolvent. Compounds of Formula I then can be purified by trituration ofthe evaporation residue with solvents such as 1-chlorobutane or ethylether and filtration, by recrystallization from mixtures of solventssuch as 1,2-dichloromethane, 1-chlorobutane, and heptane or bychromatography on silica gel.

Compounds of Formula I where R₁ is CH₂ CH₂ OH or OH can be prepared fromthe corresponding silyl compounds of Formula I where R₁ is CH₂ CH₂OSi(CH₃)₃ or OSi(CH₃)₃ simply by dissolving the silyl compounds inmethanol at 20° to 30° C. and after analytical thin layer chromatographyindicates the desilylation is complete (typically 10 minutes to 2hours), evaporating the solvent. L, R, and A are as previously defined.

Compounds (1) can be prepared by one or more of the following methods.

Many compounds (1) are prepared by reaction of the correspondingcompounds (7) with ammonia or a protected form of ammonia from which theprotecting group is subsequently removed (Equation 5). ##STR13## where Land R₁ are as previously defined except that R₁ is not CH₂ CH₂ OH or OHin (7) in Equations 5a and 5b. In Equation 5c when R₁ is CH₂ CH₂OSi(CH₃)₃ in (9) then R₁ becomes CH₂ CH₂ OH in (1) and when R₁ isOSi(CH₃)₃ in (9) then R₁ becomes OH in (1). R₁ can also be C(CH₃)₃(tert-butyl or t-Bu) except that in Equation 5c when R₁ and R₂₅ are botht-Bu in (9) then R₁ becomes H in (1). R₁ can also be Si(CH₃)₃ exceptthat in Equation 5c when R₁ is Si(CH₃)₃ in (9), R₁ becomes H in (1). InEquation 5c when R₁ is benzyl and R₂₉ is t-Bu in (9), then R₁ becomes Hin (1).

R₂₉ is C(CH₃)₃ or ##STR14##

In this method a solution of the compound (7) in a suitable anhydroussolvent, such as dichloromethane, at -70° to 80° C. is treated with atleast two equivalents (only two equivalents when R₂, R₆, or R₁₆ is CO₂R₁₇) of ammonia. The reaction mixture is allowed to warm to 20° C. andthen is shaken with water. If the products of Formula (1) are present asundissolved solids, they are filtered and dried. Otherwise, thedichloromethane solution is dried over sodium sulfate, and the solventis evaporated to leave product (1) (Equation 5a).

Although it is the most direct route, the ammonia reaction frequentlygives large amounts of polymeric by-products. For this reason, themethod illustrated by Equations 5b and 5c is generally preferred. Inthis method, a solution of compound (7) in a suitable anhydrous solventsuch as dichloromethane at -70° to -80° C. is treated with at least twoequivalents (little more than two equivalents when R₂, R₆, or R₁₆ is CO₂R₁₇) of tert-butylamine or with a little more than one equivalent of4,4'-dimethoxybenzhydrylamine and a little more than one equivalent oftriethylamine. Additional triethylamine may be useful if the startingmaterials containing (7) also contain acidic by-products from theformation of (7). The reaction mixture is then warmed to roomtemperature.

When R₂₉ is tert-butyl, the solvent is evaporated, and the residue istaken up in dichloromethane, washed with aqueous sodium bicarbonatesolution, and dried over sodium sulfate. Evaporation of the solventleaves the compound (9) (Equation 5b).

When R₂₉ is 4,4'-dimethoxybenzhydryl the reaction mixture is washed withaqueous sodium carbonate solution and dried over sodium sulfate. Thesolvent is evaporated and the residue is taken up in toluene.Evaporation of the toluene leaves compound (9) (Equation 5b).

Crude product (9) can be purified by a variety of methods known in theart including chromatography and recrystallization as appropriate.

The compound (9) is dissolved in trifluoroacetic acid at roomtemperature. Trifluoroacetic acid by itself rapidly removes the4,4'-dimethoxybenzhydryl protecting group. However, when R₂₉ istert-butyl at least one equivalent of anisole and a very strong acidsuch a trifluoromethanesulfonic acid are added. The reacton is run for0.5 to 16 hours at room temperature.

Then, if trifluoroacetic acid has been used alone, the solvent isevaporated. The residue is dissolved in a mixture of dichloromethane anda small amount of water. Sodium or potassium bicarbonate and carbonateare added until the mixture is basic. The mixture is dried over sodiumsulfate, filtered, and further dried over this desiccant. Evaporation ofthe solvent leaves free compound (1) (Equation 5c).

If an additional strong acid has been employed, sodium acetate is addedin an amount sufficient to neutralize the strong acid present. Thesolvent is evaporated, and the residue is dissolved in a mixture ofdichloromethane and a small amount of water. Sodium or potassiumcarbonate is added until the mixture is basic. The mixture is dried, andthe solvent is evaporated as described in the preceding paragraph togive free compound (1) (Equation 5c).

Crude product (1) can be purified by a variety of methods known in theart including chromatography and recrystallization as appropriate. Someof the reactions in Equations 5 (e.g., Equation 5c) cause a cleavage oftrimethylsilyl groups such that when R₁ is CH₂ CH₂ OSi(CH₃)₃ andOSi(CH₃)₃ in (7), it becomes CH₂ CH₂ OH and OH, respectively, in (1).Such purification procedures as chromatography can also effect thiscleavage. To replace the trimethylsilyl groups, one or more of a varietyof general methods for silyl ether formation reviewed by T. W. Green inProtective Groups in Organic Synthesis, Wiley-Interscience, New York,1981, can be used to convert the R₁ substituents in (1) of CH₂ CH₂ OHand OH to CH₂ CH₂ OSi(CH₃)₃ and OSi(CH₃)₃, respectively.

In some cases, R₁ can be such that the precursors to compounds (7) arenot easily prepared or are unstable. In these cases as well as manyothers, the requisite compound (1) can be prepared by the methods shownin Equations 6 and 7. ##STR15## where

L is as previously defined;

R₁ is C₁ -C₃ alkyl, CF₂ H, C₂ -C₃ alkyl substituted with 1-3 atoms of F,CH₂ CH₂ OCH₃, CH₂ CH₂ OH or SO₂ CH₃ ; and

X' is Cl, Br, I, ##STR16## O⁺ (R₁)₂ or S⁺ (R₁)₂.

R₁ X' (10) can be ##STR17## also.

In this method, a solution of compound (1a) (prepared via the methoddescribed in Equation 5) in a suitable solvent such asN,N-dimethylformamide is treated with one equivalent of a suitablestrong base such as sodium hydride containing catalytic sodiumtert-butoxide. The mixture is then treated with at least one equivalentof R₁ X' (10). The reaction is run at 20° to 100° C. for 0.5 to 16hours. When R₁ X' (10) is a highly reactive reagent such as (R₁)₃ O⁺ Bf₄⁻ or CH₃ SO₂ Cl, little more than one equivalent of (10) is used, asolvent like dichloromethane is used in place of theN,N-dimethylformamide, a base like N,N-diisopropylethylamine is used inplace of the sodium hydride-tert-butoxide mixture, and the reactiontemperature is reduced to 0° to 40° C.

To work up the reaction, the solvent is evaporated and the residue isdissolved in a mixture of dichloromethane and water. When R₁ is SO₂ CH₃,the mixture is acidified to pH 4 with hydrochloric acid. Thedichloromethane layer is separated and dried over sodium sulfate.Evaporation of the solvent leaves sulfonimidamide (9a) (Equation 6a).

Sulfonodiimidamide (1b) (prepared via the method described in Equation5) is converted to sulfonodiimidamide (11) by the method alreadydescribed for the conversion of (1a) to (9a) in Equation 6a (Equation6).

Compounds (9 and 11) are converted to (1) as already described forEquation 5c (Equations 6c and 6d).

Finally, sulfonodiimidamide (12) is converted to (1) (G=NR₁) by themethod already described for the conversion of (1a) to (9a) in Equation6a (Equation 6e).

Alternatively, as shown in Equation 7 the free compound (1b) can bereacted directly with alkylating, benzylating, and sulfonating reagentsto give N-substituted derivatives of Formula (1). The method isespecially useful for the preparation of N-substituted sulfonimidaminesof Formula (1) where the N-substituent R₁ is unstable to the strong acidneeded to cleave the tert-butyl group in the method depicted in Equation6. Benzyl is usually cleaved by the necessary strong acid, andmethanesulfonyl may be cleaved in some cases. A relative disadvantage ofthe method depicted in Equation 7 is that polyalkylation side reactionsmay be more significant in some cases than with the method depicted inEquation 6. This dis-advantage becomes an advantage in the preparationof N-substituted sulfonodiimides of Formula (1) (G=NR₁), since thenecessary bis-substitution may be carried out in a single step.##STR18## where L, R₁, X' and R₁ X' are as defined for Equation 6,except that R₁ can also be benzyl.

Unsubstituted compound (1b) (G=0) is converted to N-substituted (1)(G=0) by the general method already described for the conversion of (1a)to (9a) in Equation 6a (Equation 7a). Similarly, unsubstitutedsulfonodiimidamide (1b) (G=NR₁) is converted to N,N'-disubstitutedsulfonodiimidamide (G=NR₁) by the method already described for theconversion of (1a) to (9a) in Equation 6a except that twice as much baseand R₁ X' (10) is used (Equation 7).

Sulfonimidoyl chlorides and sulfonodiimidoyl chlorides of Formula (7)can be prepared by one or more of the following methods.

In the most generally useful method, compounds (13) are chlorinated togive compounds (7), as shown in Equation 8. ##STR19## where L and R₁ areas defined for (7) in Equation 5.

In this method, compound (13) is treated with at least one equivalent(only one equivalent when other sensitive functionalities are present)of chlorine or other chlorinating agent such as tert-butyl hypochloriteor N-chlorobenzotriazole according to the general procedures, ormodifications thereof known to those skilled in the art, described by C.R. Johnson and co-workers (see C. R. Johnson, E. U. Jonsson, C. C.Bacon, J. Org. Chem., 44, 2055 (1979), and C. R. Johnson, A. Wambsgans,J. Org. Chem., 44 2278 (1979)) to give sulfonimidoyl chloride (7)(Equation 8). In general, the use of chlorine is preferred from thestandpoint of cost and convenience. However, when other sensitivefunctionalities are present, N-chlorobenzotriazole and particularlytert-butyl hypochlorite may be more useful.

Some of compounds (7) can be prepared from the corresponding compounds(14) as shown in Equation 9. ##STR20## where L and R₁ are as defined for(7) in Equation 5, except that R₁ is not H, CF₂ H, OSi(CH₃)₃, phenyl orbenzyl.

In this method, compound (14) is treated with slightly more than oneequivalent of Cl₂ NR₁ (15); see E. S. Levchenko, L. N. Markovskii, A. V.Kirsanov, Zh. Org. Khim., 3, 1481 (1967); J. Org. Chem. USSR., 3, 1439(1967) and C. R. Johnson, E. U. Jonsson, C. C. Bacon op. cit. to givesulfonimidoyl chloride (7) (Equation 9).

The requisite N,N-dichloro reagents (15) are either known in the art orcan be made from the corresponding free amino compounds H₂ NR₁ (16) byfollowing general procedures such as those described by E. S. Levchenko,A. V. Kirsanov in Zh. Obshch. Khim., 30, 1553 (1960); J. Gen. Chem.USSR, 30, 1562 (1960)). The requisite amino compounds H₂ NR₁ (16) areknown or capable of preparation by a variety of methods known in theart.

The preparation of the requisite compounds (14) is described furtherbelow.

Compounds (13) (G=0) are prepared by one or more of a variety of methodsknown in the art. A number of these methods are tabulated in Equation10. ##STR21## where L and R₁ are as defined in Equation 8 except that R₁is not CF₂ H. In Equation 10c, R₁ is not SO₂ CH₃. In Equation 10 e, M isLi or Mg, and L is restricted to structures where methodology is knownfor regioselective preparation of stable organometallic reagents (20).

In the first and probably most common method, a solution of compound(14a) in a suitable solvent such as dichloromethane at -80° to -70° C.is treated with at least two equivalents (only two equivalents when R₂,R₆, or R₁₆ is CO₂ R₁₇) of H₂ NR₁ (16). When H₂, NR₁ (16) is nottrivially accessible or is relatively nonbasic, one equivalent of asuitable base such as triethylamine may be substituted for one of thetwo equivalents of H₂ NR₁ (16). The reaction mixture is warmed to -10°to 30° C. and is then washed with water and dried over sodium sulfate.Evaporation of the solvent leaves sulfinamide (13a) (Equation 10a). Therequisite amino compounds H₂ NR₁ (16) are either known in the art or canbe made by a wide variety of methods known in the art.

Sulfinamides (13a) can be prepared from the corresponding sulfinic acids(17), the amino compounds H₂ NR₁ (16), and a coupling agent according togeneral procedures of M. Furukawa and T. Okawara in Synthesis, 339(1976) and M. Furukawa, T. Ohkawara, Y. Noguchi, M. Nishikawa and M.Tomimatsu in Chem. Pharm. Bull., 28, 134 (1980) (Equation 10b).

Sulfinamides (13a) can be prepared from the corresponding activatedsulfinamides (18) and the amino compounds H₂ NR₁ (16) according to thegeneral procedure of D. N. Harpp and T. G. Back in J. Org. chem., 38,4328 (1973)(Equation 10c). Methods for the preparation of the activatedsulfinamides (19) are disclosed in the paper by Harpp and Back and thereferences cited therein.

Sulfinamides (13a) can be prepared by oxidation of the correspondingsulfenamides (19) according to the general procedure of M. Haake, H.Gebbing, and H. Benack in Synthesis 1979, 97 (Equation 10d).Sulfenamides (19) are prepared from the corresponding sulfenyl chloridesLSCl (22) and other compounds by the methods reviewed by A. Schoberl andA. Wagner "Methoden zur Herstellung und Umwandlung von Sulfensauren andSulfensaurederivaten" in Methoden Org. Chem. (Houben-Weyl), Vol. 9, 263(1955); D. R. Hogg "Sulphenic Acids and Their Derivatives inComprehensive Organic Chemistry, Vol. 3, D. N. Jones ed., PergamonPress, New York, 1979 and E. Kuhle The Chemistry of the Sulfenic Acids,Georg Thieme, Stuttgart, 1973.

Finally, in some cases sulfinamides (13a) can be prepared fromorganometallic reagents and N-sulfinylamines (21) according to thegeneral procedure of D. Klamann, C. Sass, and M. Zelinka in Chem. Ber.,92, 1910 (1959) (Equation 10e). The preparation of N-sulfinylamines hasbeen reviewed by G. Kresze, A. Maschke, R. Albrecht, K. Bederke, H.Patzschke, H. Smalla, A. Trede in Angew. Chem., Int. Ed. Engl., 1, 89(1962); and by G. Kresze, W. Wucherpfennig in Angew Chem., Int. Ed.Engl., 6, 149 (1967).

Although not shown in Equation 10, in some cases sulfinamides (13a) canbe prepared from sulfoximides according to the general procedure of R.Sato, N. Saito, Y. Takikawa, S. Takizawa, and M. Saito in Synthesis1983, 1045. For general reviews of the preparation of sulfinamides (13a)by some of the methods already described and others, see F. Muth"Methoden zur Herstellung und Unwandlung von Aromatischen Sulfinsauren"in Methoden Org. Chem. (Houben-Weyl), Vol. 9, 299 (1955) and K. K.Andersen "Sulphinic Acids and Their Derivatives" in ComprehensiveOrganic Chemistry, Vol. 3, D. N. Jones ed., Pergamon Press, New York,1979.

Compounds (13) (G=NR₁) are prepared by one or more of the methods shownin Equation 11. ##STR22## where L, M and R₁ are as defined for Equation10.

In the first and most general method, sulfenamide (19) is converted tosulfinimidoyl chloride (15a) using the same general procedures, ormodifications thereof known to those skilled in the art, already notedfor the conversion of (13) to (7) in Equation 8 (Equation 11a). Thensulfinimidoyl chloride (15a) is converted to sulfinimidamide (13b) usingthe same general procedure, or modifications thereof known to thoseskilled in the art, already noted for the conversion of (14) to (13) inEquation 10a (Equation 11b). Alternatively, in some cases asulfinimidamide of Formula (13b) can be prepared by condensation of theappropriate organometallic reagent (20) with the appropriate sulfurdiimide (23) using the same general procedure, or modifications thereofobvious to those skilled in the art, already noted for the conversion of(20) and (21) to (13a) in Equation 10e (Equation 11c). Methods for thepreparation of sulfur diimides have been reviewed by C. R. Johnson,"Sulfur Di-imines" in Comprehensive Organic Chemistry, Vol. 3, D. N.Jones ed., Pergamon Press, New York, 1979.

In some cases, when R₂, R₆ or R₁₆ is CO₂ R₁₇, the methods shown inEquations 6, 7, 10 and 11 can be complicated by side reactions involvingintramolecular closure between a sulfur-attached nitrogen atom and theester carbonyl carbon atom. In some of these cases as well as otherswhen R₂, R₆ or R₁₆ is CO₂ R₁₇, this tendency to intramolecular closurecan be used to advantage. The closure is effected when the bridgingsulfur is in low oxidation state as shown in Equation 12. ##STR23##where p is 0 or 1 and R₁₇ is as previously defined.

In this method, a solution of a sulfinyl chloride of Formula (14a) or asulfenyl chloride of Formula (22a) in a suitable solvent such asdichloromethane at -80° to -60° C. is treated with at least twoequivalents of ammonia. The mixture is warmed to about 0° C. and at thistemperature is treated with at least two equivalents of a suitablestrong base such as 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). Thereaction mixture is warmed and held at 20° to 40° C. for 0.5 to 8 hours.The solution is then washed with aqueous 1N hydrochloric acid and driedover sodium sulfate. Evaporation of the solvent leaves the cyclicsulfinamide of Formula (24) or sulfenamide of Formula (25) respectively(Equation 12).

The cyclic sulfinamides of Formula (24) and sulfenamides of Formula (25)are then converted to cyclic compounds of Formula (26) by use of methodsand procedures, or modifications thereof obvious to those skilled in theart, analogous to those already discussed in connection with Equations5, 6, 7, 8 and 11.

The cyclic compounds (26) are then opened to give the correspondingsulfonimidamides of Formula (1c) as shown in Equation 13. ##STR24##where G is as previously defined;

R₁ is as previously defined, except that when R₁ is CH₂ CH₂ OSi(CH₃)₃ orOSi(CH₃)₃ in (26). R₁ becomes CH₂ CH₂ OH or OH, respectively, in (1c);and

R₁₇ is as previously defined.

In this method a solution or suspension of a cyclic compound (26) in R₁₇OH (27) is treated with a suitable acid catalyst such as hydrogenchloride. The mixture is heated at 50° to 100° C. for 1 to 6 hours. Thesolvent is evaporated, and the residue is dissolved in dichloromethanecontaining a small amount of water. The mixture is neutralized withsodium bicarbonate and dried over excess sodium sulfate. Evaporation ofthe solvent leaves the compound (1c) (Equation 13).

Compounds of Formula (1c) where R₁ is CH₂ CH₂ OSi(CH₃)₃ or OSi(CH₃)₃ canbe prepared from the corresponding compounds of Formula (1c) where R₁ isCH₂ CH₂ OH or OH respectively as noted previously for compounds ofFormula (1) in the discussion following Equation 5.

Sulfinyl chlorides (14) are prepared by treatment of either thecorresponding sulfinic acids (17) or their salts with thionyl chloride,or by oxidation of the corresponding thiols or thiol derivatives withchlorine or another chlorinating agent. Potentially suitable thiolderivatives include disulfides, sulfenyl chlorides (22), and especiallythiolesters. Sulfinic acids (17) are prepared by a variety of methodsincluding the reduction of the corresponding sulfonyl halides or othersulfur derivatives; the oxidation of the corresponding thiols or thioderivatives; the reaction of sulfur dioxide with diazonium salts, withorganometallic reagents LM (20). or directly with suitable aromatichydrocarbons via a Friedel-Crafts procedure; and the cleavage ofsulfones.

For reviews of many of the methods for making sulfinic acids andsulfinyl chlorides, see F. Muth (op. cit.) and K. K. Anderson (op.cit.).

Sulfonyl chlorides are prepared by a wide variety of methods known inthe art. Some of these methods include the chlorination of thecorresponding sulfur compounds of lower oxidation state such as thiols,sulfides, disulfides, xanthates, isothiocyanates, thiosulfsates, andisothiouronium salts. Other methods include the coupling of diazoniumsalts with sulfur dioxide and chlorine ion in the presence of Cu (II),and the reaction of chlorosulfonic acid with suitable aromatichydrocarbons. Finally, one general method involves the preparation ofsulfonyl chlorides from the corresponding sulfonic acids or their salts.A variety of methods exists in the art for the preparation of sulfonicacids. For reviews of many of the methods for making sulfonic acids andsulfonyl halides, see H. Eckaldt "Sulfochlorierung nach C. F. Reed" in(Houben-Weyl), Vol. 9, 407 (1955); F. Muth ∓Methods zur Herstellung undUmwandlung Aromatischer Sulfonsauren" in (Houben-Weyl). Vol. 9, 429(1955), F. Muth ∓Methoden zur Herstellung und Umwandlung AromatischeSulfohalogenide" in (Houben-Weyl), Vol. 9, 557 (1955); K. K. Andersen"Sulfonic Acids and Their Derivatives" in Comprehensive OrganicChemistry, Vol. 3, D. N. Jones ed., Pergamon Press, New York, 1979; andthe reviews cited therein.

Sulfenyl chlorides LSCl (22) are generally prepared by chlorination ofthe corresponding disulfides, thiols or certain thiol derivatives suchas benzyl sulfides and thiolesters are reviewed by D. R. Hogg (op.cit.). Thiols and thiol derivatives such as sulfides, disulfides,xanthates, thiolesters, isothiocyanates, and isothiouronium salts areprepared by a variety of methods known in the art. Some of these methodsinclude the reaction of sulfur-based nucleophiles with aromaticdiazonium salts or with aromatic systems containing a halogen atom orother leaving group suitable to nucleophilic displacement. Other methodsinclude the reaction of sulfur or other sulfur electrophiles withorganometallic reagents LM (20). Still other methods include thereaction of active sulfur based electrophiles such as sulfurmonochloride with suitable aromatic hydrocarbons via a Friedel-Craftstype procedure. Highly useful methods such as the Newman-Kwarltrearrangement and related procedures are known in the art for conversionof a hydroxyl group to thiol derivatives.

In addition to being preparable by the above noted substitution-typereactions, many heteroaromatic thiols and thiol derivatives are preparedby a variety of methods in which the sulfur atom has been incorporatedinto a nonheteroaromatic precursor to the heterocyclic system. Forreviews of many of the methods for making thiols and thiol derivatives,see A. Schoberl and A. Wagner "Methoden zur Herstellung und Umwandlungvon Mercaptamen und Thiophenolen" in (Houben-Weyl), Vol. 9, 3 (1955); A.Schoberl and A. Wagner "Methoden zur Herstellung und Umwandlung vonDisulfiden" in (Houben-Weyl), Vol. 9, 55 (1955); A. Schoberl and A.Wagner "Methoden zur Herstellung und Umwandlung von Mercaptalen undMercaptolen" in (Houben-Weyl), Vol. 9, 195 (1955); A. Schoberl and A.Wagner " . . . Sulfensauren und Sulfensaurederivate" (op. cit.); G. C.Barrett "Thiols" in Comprehensive Organic Chemistry, Vol. 3, D. N. Jonesed.; Pergamon Press, New York, 1979; D. R. Hogg (op. cit.); E. Kuhle(op. cit.); and the reviews cited therein. For an additional review ofmany of the methods for making carbon-sulfur bonds see D. Martin"Formation of Carbon-Sulfur Bonds" in Preparative Organic Chemistry, G.Hilgetag and A. Martini ed., Wiley-Interscience, 1972.

The construction of the aromatic nucleus of L and the introduction andelaboration of substituents, including any needed for the introductionof the sulfonimidoylurea or sulfonodiimidoylurea bridge sulfur atom asnoted above, are accomplished using methods known in the art, ormodifications thereof obvious to those skilled in the art. Inparticular, for cases where L is L-1 and R₂ is a heterocycle, refereceto the useful methods taught in European Patent Publications 83,975(published July 20, 1983) and 85,476 (published Aug. 10, 1983) issuggested. For cases where L is L-7, L-8, L-9, L-10, L-11, L-12, L-13,L-14 or L-15, reference to the useful methods taught in European PatentApplication (EP-A) No. 107,979 (published May 9, 1984) is suggested.

Compounds (6) are prepared from the corresponding compounds (1) by oneof the following three general methods. ##STR25## where G is aspreviously defined; and

L and R₁ are as defined for Equation 4.

The compound (1) and an alkyl isocyanate (e.g., n-butyl isocyanate) inxylene or other solvent boiling above 135° C. are mixed in the presenceor absence of a catalytic amount of 1,4-diaza[2.2.2]bicyclooctane(DABCO) and heated to 135° to 140° C. After 5 to 60 minutes phosgene isslowly added to the heated mixture at such a rate that the temperatureremains between 133° and 135° C. When the consumption of phosgene hasceased, the mixture is cooled and filtered to remove insoluble material.Finally, the solvent, alkyl isocyanate, and excess phosgene areevaporated, leaving the compound (6).

If desired, in many cases the alkyl isocyanatesulfonimidamide or alkylisocyanate-sulfonodiimidamide adduct can be made and isolated beforereaction with the phosgene. In this case, the compound (1), alkylisocyanate, and anhydrous base (e.g., K₂ CO₃) in a polar, aproticsolvent (e.g., acetone, butanone, or acetonitrile) are mixed and heatedunder reflux for 1 to 6 hours. The reaction mixture is then diluted withwater, and the pH is adjusted to about 4 with acid (e.g., HCl, H₂ SO₄).The adduct is filtered out and dried, and then reacted with phosgene asdescribed above. This procedure modification is especially useful whencompound (1) is high melting and has low solubility in the phosgenationsolvent.

Compounds (6) can also be prepared by the following method. ##STR26##where L, R₁ and G are as defined for Equation 14.

The compound (1) is heated at reflux in an excess of thionyl chloride.The reaction is continued until the amide protons are no longerdetectable in the proton magnetic resonance spectrum. From 16 hours to 5days is typically sufficient for complete conversion to thethionylamides (26) (Equation 15a).

The thionyl chloride is evaporated and the residue is treated with aninert solvent such as toluene containing at least one equivalent(typically 2-3 equivalents) of phosgene. A catalytic amount of pyridine(typically 0.1 equivalent) is added, and the mixture is heated to about60° to 140° C., with 80° to 100° preferred. Conversion to the isocyanate(6) is usually substantially complete within 15 minutes to 3 hours(Equation 15b). The mixture is then cooled and filtered, and the solventis evaporated, leaving compound (6).

Occasionally a compound (1) may not be of sufficient stability to beuseful as a starting material in Equations 14 and 15. In this case aswell as others, compound (6) can be made as an unisolated intermediateby treating the corresponding compound (7) with isocyanate anion in thepresence of the heterocyclic amine (4). The amine reacts with compound(6) as it is formed to give the desired compound of Formula I (Equation16). ##STR27## where L and R₁ are as defined for Equation 14; and

A, G and R are as previously defined.

The reaction is best carried out by adding over one to six hours asolution of at least one equivalent of a tetraalkylammonium isocyanate,such as tetra-n-butylammonium isocyanate, in a suitable aprotic organicsolvent, such as dichloromethane or tetrahydrofuran, to a well-stirredmixture of one equivalent of compound (7) and at least one equivalent ofheterocyclic amine (4) in a similar suitable organic solvent at 20° to40° C. The reaction mixture is then diluted with dichloromethane, washedwith 1N sulfuric acid, and dried over sodium sulfate. Rotary evaporationof the solvent leaves the product of Formula I in crude form. This canbe purified as has already been described for Equation 4.

The heterocyclic amines of Formula (4a) to (4d) below are either known,disclosed in this application, or can be prepared by obvious methods byone skilled in the art. ##STR28##

For a review of the synthesis and reactions of 2-amino- and2-methylaminopyrimidines (4a, Z=CH) see The Chemistry of HeterocyclicCompounds, Vol. 16, Wiley-Interscience, New York (1962). For a review ofthe synthesis and reactions of 2-amino- and 2-methylamino-s-triazines(4a, Z=N) see The Chemistry of Heterocyclic Compounds, Vol. 13,Wiley-Interscience, New York (1959), F. C. Schaefer, U.S. Pat. No.3,154,537 and F. C. Schaefer and K. R. Huffman J. Org. Chem., 28, 1812(1963). The synthesis of the bicyclic amines (4b) and (4c) is taught inU.S. Pat. No. 4,339,267. The synthesis of bicyclic amines (4d) is taughtin European Patent Application (EP-A) 46,667.

Compounds of Formula (4e) are described in EP-A-73,562. Compounds ofFormula (4f) are described in EP-A-94,260.

The amines of Formula (4g) can be prepared by methods taught in EuropeanPublication No. 125,864 (published 11/21/84) or by suitablemodifications that would be obvious to one skilled in the art.

The amines of Formula (4) where X or X₁ is OCF₂ H and/or Y is OCF₂ HSCF₂ H can be prepared by methods taught in South African PatentApplication 825,045, or by suitable modifications that would be obviousto one skilled in the art.

The pyrimidines of Formula (4a) (Z=CH) where ##STR29## can be preparedaccording to the methods taught in European Patent Application (EP-A)84,224 or suitable modifications thereof known to one skilled in theart.

The carbamate intermediates (2) are prepared by the following method.##STR30## where A is as previously defined.

In this method, a solution or slurry of the appropriate heterocycle (4)in a suitable aprotic solvent (e.g., tetrahydrofuran, dioxane, glyme) at0° to 30° C. is treated wih two equivalents of sodium hydride. After gasevolution ceases, the reaction mixture is treated with one equivalent ofdimethyl carbonate and stirred at 20° to 30° C. for 8 to 24 hours toprovide a suspension of the sodium salt (27) (Equation 17a).

Sufficient concentrated hydrochloride acid is then added to bring the pHto 4. The mixture is saturated with sodium chloride and filtered. Theorganic layer is separated away from the aqueous layer, dried overmagnesium sulfate, and filtered. Evaporation of the solvent leaves theheterocyclic carbamate (2, R=H) (Equation 17b).

Alternatively, the reaction mixture containing (27) formed in Equation17a is treated with at least two equivalents of iodomethane and thenheated at 60° to 80° C. for 8 to 24 hours. The mixture is cooled andfiltered, and the solvent is evaporated. The residue is taken up indichloromethane, washed with water, and the solvent is evaporated,leaving the N-methyl carbamate (2, R=CH₃) (Equation 17c).

In some cases, heterocycles of Formula (4) can be more easily preparedwith R being H than with R being CH₃. Many heterocycles (4, R=CH₃) canbe prepared from the corresponding heterocycles (4, R=H) by one or moreof the following two methods. ##STR31## where A is as previouslydefined.

In this method, the carbamate (2, R=CH₃) prepared from (4, R=H)(Equations 17a and 17c) is dissolved in anhydrous, alcohol-freechloroform saturated with propylene gas. Slightly more than oneequivalent (typically 1.1-1.2 equivalents) of iodotrimethylsilane isadded and the stirred solution is heated at 50° to 60° C. for 2 to 4hours. The mixture is cooled and two equivalents of methanol is added.The solvent is evaporated and the residue is taken up in methanol. Themixture is carefully neutralized with 10% sodium methoxide in methanol,and then the solvent is evaporated. The residue is triturated withice-water. If a precipitate forms, it is filtered out, rinsed withice-water and dried to provide (4, R=CH₃). If no precipitate forms, thesolution is saturated with sodium chloride and extracted with ethylacetate. Evaporation of the solvent leaves the heterocycle (4, R=CH₃).

Alternatively, the following two-step procedure is useful in many cases.##STR32## where A is as previously defined.

A solution of the amine (4, R=H) in concentrated hydrochloric acid istreated with sodium nitrite solution and the chloro compound (28) isisolated in the usual manner by filtration of the acidic solution(Equation 19a). A representative procedure is described by Bee and Rosein J. Chem. Soc. C., 2031 (1966), for the case in which Z=CH, andX=Y=OCH₃.

The heterocycle (28) is then treated with at least two equivalents ofmethylamine in a suitable inert solvent (e.g., tetrahydrofuran, glyme,or diglyme) at a temperature between 20° and 80° C. for 1 to 18 hours(Equation 19b). The reaction mixture is then cooled and filtered.Evaporation of the solvent leaves (4, R=CH₃) contaminated with a littleCH₃ NH₃ ⁺ Cl⁻ salt. The product can be purified by trituration withice-water or by dissolution in dichloromethane, followed by washing witha small amount of water, drying, and evaporation of solvent. Furtherpurification can be accomplished by recrystallization or columnchromatography on silica gel.

Following is a typical reaction pathway for one specific compound of theinvention: ##STR33##

The following examples further illustrate the synthesis of thisinvention.

EXAMPLE 1 S-2-Bromophenyl ethanethioate

A stirred solution of 2-bromothiophenol (100 g, 0.529 mol), aceticanhydride (62.4 mL, 0.661 mol), and 4-dimethylaminopyridine (3.2 g,0.026 mol) in dichloromethane (1000 mL) was cooled in an ice-bath.Triethylamine (92.2 mL, 0.662 mol) was slowly added, and then the icebath was removed. The mixture was stirred at room temperature for 1hour. Water (10 mL) was added, and after a couple of minutes the mixturewas washed with aqueous 1N hydrochloric acid (3×300 mL), 10% sodiumhydroxide solution (3×300 mL), and 1N hydrochloric acid (300 mL), andthen dried (Na₂ SO₄), and filtered. Evaporation of the solvent leftS-2-bromophenyl ethanethioate as a pale yellow oil (104 g).

PMR (CDCl₃, 200 MHz): δ7.70 (dd, 1H, Ar-H); 7.54 (dd, 1H, Ar-H); 7.36(td, 1H, Ar-H); 7.27 (td, 1H, Ar-H); 2.46 (s, 3H, C(O)CH₃). IR (Neat):1709 (vs, C=0) cm⁻¹.

EXAMPLE 2 2-Bromobenzenesulfinyl Chloride

A stirred mixture of S-2-bromophenyl ethanethioate (46.2 g, 0.200 mol)and acetic anhydride (20.4 g, 0.200 mol) was cooled to -10° C. Liquifiedchlorine (18.1 mL, 0.400 mol) was added at such a rate that thetemperature remained below 5° C.; a dry ice-filled Dewar condenser wasused to prevent the loss of the reagent. The mixture was warmed to roomtemperature and after 1.5 hours was briefly heated to 50° C. The acetylchloride present was evaporated, and the residue was taken up intoluene. Evaporation of this solvent left 2-bromobenzenesulfinylchloride as a pale orange yellow oil (49.7 g).

PMR(CDCl₃, 200 MHz): δ8.14 (dd, 1H, Ar-H ortho to S(O)Cl); 7.66 (dd, 1H,Ar-H ortho to Br); 7.64 (td, 1H, Ar-H); 7.51 (td, 1H, ArH). The crudeproduct was used in the next step without further characterization orpurification.

EXAMPLE 3 2-Bromo-N-methylbenzenesulfinamide

Liquified methylamine (36.3 mL, 0.817 mol) was added slowly to a stirredsolution of 2-bromobenzenesulfinyl chloride (48.9 g, 0.204 mol) indichloromethane (489 mL) cooled below -70° C. The reaction mixture wasallowed to warm to -10° C. and was then shaken with water (489 mL). Thelayers were separated, and the dichloromethane layer was washed withwater (2×245 mL), dried (Na₂ SO₄), and filtered. Evaporation of thesolvent left a pale yellow oil (44.4 g) that mostly crystallized onstanding. This was dissolved in dichloromethane and chromatographed on acolumn of silica gel using 2:1 dichloromethaneether as eluant. Fractionscontaining product (R_(f) =0.52, UV) were evaporated to leave2-bromo-N-methylbenzenesulfinamide as a white crystalline solid (39.5 g)melting at 66°-70° C.

PMR (CDCl₃, 200 MHz): δ7.98 (dd, 1H, Ar-H ortho to S(O)Cl); 7.61 (dd,1H, Ar-H ortho to Br); 7.52 (td, 1H, Ar-H); 7.36 (td, 1H, Ar-H); 4.01(broad s, 1H, NH); 2.57 (d, 3H, N-CH₃). IR(Nujol): 3200 (s, NH); 1040(vs, multiple components, SO) cm⁻¹.

EXAMPLE 4 2-Bromo-N-(1,1-dimethylethyl)-N'-methylbenzenesulfonimidamide

A solution of 2-bromo-N-methylbenzenesulfinamide (2.34 g, 0.010 mol) andpyridine (0.81 mL, 0.010 mol) in dichloromethane (40 mL) was cooledbelow -70° C. Liquified chlorine (0.91 mL, 0.020 mol) was addeddropwise. The reaction mixture was warmed to room temperature, and thesolvent was evaporated leaving a white semisolid. This was mostlydissolved in dichloromethane (40 mL) and cooled below -70° C.Tert-butylamine (5.3 mL, 0.050 mol) was slowly added, and then themixture was allowed to warm to room temperature. The solvent wasevaporated, and the residue was dissolved in toluene and againevaporated. The residue was taken up in dichloromethane (ca. 60 mL),washed with saturated aqueous sodium hydrogen carbonate solution (3×25mL), dried (Na₂ SO₄), and filtered. The solvent was evaporated, and theresidue was taken up in toluene. Further evaporation afforded a yellowoil (3.0 g). This was dissolved in dichloromethane and chromatographedon a column of silica gel using 10:1 followed by 5:1dichloromethane-ether as eluant. Fractions containing product (R_(f)=0.42, 10:1 CH₂ Cl₂ -Et₂ O, UV) were evaporated to yield2-bromo-N-(1,1-dimethylethyl)-N'-methylbenzenesulfonimidamide as a paleyellow oil (1.9 g) that on standing formed a crystalline solid meltingat 86°-87° C.

PMR(CDCl₃, 200 MHz): δ8.23 (dd, 1H, Ar-H ortho to S(O)(NCH₃)(NH-t-Bu));7.68 (dd, IH, Ar-H ortho to Br): 7.43 (td, 1H, Ar-H); 7.32 (td, 1H,Ar-H), 4.86 (broad s, 1H, NH); 2.57 (s, 3H, NCH₃); 1.31 (s, 9H, t-Bu).IR(Nujol): 3310 (m, NH) cm⁻¹.

EXAMPLE 5 2-Bromo-N'-methylbenzenesulfonimidamide

Cleavage of the tert-butyl group from2-bromo-N-(1,1-dimethylethyl)-N'-methylbenzenesulfonimidamide by use oftrifluoroacetic acid with or without added boron trifluoride etheratewas found to be slow at room temperature.2-Bromo-N-(1,1-dimethylethyl)-N'-methylbenzenesulfonimidamide (0.9 g,2.9 mmol) recovered from these cleavage experiments and anisole (0.6 g,5.5 mmol) were dissolved in trifluoroacetic acid (25 mL).Trifluoromethanesulfonic acid (ca. 9 g, 60 mmol) was added and thereaction mixture was stirred at room temperature for 1 hour. Then sodiumacetate (5.5 g, 67 mmol) was added and the solvent was evaporated toleave a solid residue. This was dissolved in a mixture ofdichloromethane and a small amount of water. Potassium carbonate wasadded until the mixture became basic. The mixture was partially dried(Na₂ SO₄), filtered through Celite®, redried (Na₂ SO₄), and gravityfiltered. Evaporation of the solvent left a slightly brownish oil (1.4g). This was dissolved in dichloromethane and chromatographed on acolumn of silica gel using 40:1 CH.sub. 2 Cl₂ -Et₂ O followed by 1:1 CH₂Cl₂ -Et₂ O as eluant. Fractions containing the product (R_(f) =0.44,10:1 CH₂ Cl₂ -Et₂ O, UV) were evaporated to leave2-bromo-N'-methylbenzenesulfonimidamide as a colorless oil (0.7 g).

PMR (CDCl₃, 200 MHz): δ8.28 (dd, 1H, Ar-H ortho to S(O)NCH₃)(NH₂)); 7.74(dd, 1H, Ar-H ortho to Br); 7.48 (td, 1H, Ar-H); 7.40 (td, 1H, Ar-H);2.59 (s, 3H, NCH₃); 2.5-5.5 (extremely broad s, 2H, NH₂). IR (film):3270 (s, broad, NH₂) cm⁻¹.

EXAMPLE 62-Bromo-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-N'-methylbenzenesulfonimidamide

1,8-Diazabicyclo[5.4.0]undec-7-ene (0.15 mL, 1.0 mmol) was addeddropwise over one minute to a stirred solution of2-bromo-N'-methylbenzenesulfonimidamide (0.25 g, 1.0 mmol) and phenyl(4.6-dimethoxypyrimidin-2-yl)carbamate (0.28 g, 1.0 mmol) in dryacetonitrile (5 mL) at room temperature. The solvent was evaporated, andthe residue was dissolved in dichloromethane. Evaporation of thissolvent left a pale yellow viscous oil (0.65 g). This was dissolved inCH₂ Cl₂, and acetic acid (57 μL, 1.0 mol) was added. This solution waschromatographed on a column of silica gel using 1:1dichloromethane-ether as eluant. Fractions containing the product werediluted with toluene. The solvent was evaporated leaving an oil. Thiswas dissolved in dichloromethane, and the solvent was evaporated leaving2-bromo-N-(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl-N'-methylbenzenesulfonimidamideas a hard amorphous foam (0.45 g) melting at 120°-125° C.

PMR (CDCl₃, 200 MHz) δ ca. 7-15 (extremely broad s exchanging with H₂ O,1H, S(O)(NCH₃)NHCO); 8.26 (dd, 1H, Ar-H ortho to S(O)(NCH₃)NHCO); 7.78(broad s, 1H, CONH-Het); 7.76 (dd, 1H, Ar-H ortho to Br); 7.51 (td, 1H,Ar-H); 7.43 (td, 1H, Ar-H); 5.68 (s, 1H, Het 5-H); 3.88 (s, 6H,Het-OCH₃); 2.66 (s, 3H, NCH₃). Only a few very minor impurity peaks werepresent. IR (Nujol): ca. 3000 (w, very broad, NH); 1670 (s, C=0) cm⁻¹.Chemical ionization mass spectral analysis showed a molecular ionderived peak at m/e 430 (M+1) with a Br⁸¹ isotope satellite peak at m/e432.

EXAMPLE 72-Chloro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)-aminocarbonyl]-N'-methylbenzenesulfonimidamide

To a solution of 196.8 mg (0.96 mmol) of2-chloro-N'-methylbenzenesulfonimidamide and 250 mg (0.96 mmol) ofphenyl(4-methoxy-6-methyl-1,3,5-triazin-2-yl)-carbamate in 5 mL of dryacetonitrile was added 0.15 mL (1.0 mmol) of1,8-diazabicyclo[5.4.0]-undec-7-ene. After 45 minutes at roomtemperature, 5 mL of water and 2.5 mL of 5% HCl were added. The aqueouslayer was extracted with methylene chloride (3×10 mL). The organic layerwas dried (Na₂ SO₄), filtered and the solvent was removed with a rotaryevaporator. The residue was triturated with ethyl acetate to give 80 mgof a white solid; m.p. 154° to 160° C.

¹ H NMR (d₆ -DMSO): δ2.52 (s, 3H); 2.70 (s, 3H); 3.98 (s, 3H); 7.55 (m,4H); 8.22 (d, 1H).

EXAMPLE 8N-[(4,6-Dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(methylsulfonyl)benzenesulfonimidamide

To a solution of 62.6 mg (0.267 mmol) of2-(methylsulfonyl)benzenesulfonimidamide and 73.5 mg (0.21 mmol) ofphenyl(4,6-dimethoxypyrimidin-2-yl)-carbamate in 1.3 mL of dryacetonitrile was added 0.04 mL (0.27 mmol) of1,8-diazabicyclo[5.4.0]undec-7-ene. After 45 minutes at roomtemperature, 1.3 mL of water and 0.65 mL of 5% HCl were added. A solidprecipitated out of solution. This material was isolated by filtration,washed with ether to give 60 mg of a white solid; m.p. 135° to 145° C.(d).

¹ H NMR (d₆ -DMSO): δ3.48 (s, 3); 3.87 (s, 3); 5.90 (s, 1); 8.05 (m, 2);8.28 (m, 2); 10.52 (brs, 1).

Using the procedures and examples shown above, one skilled in the artcan prepare the compounds in Tables 1-32. ##STR34##

                                      TABLE 1                                     __________________________________________________________________________    General Structure 1                                                           R.sub.2   R.sub.3                                                                              R  X    Y      Z  m.p. (°C.)                          __________________________________________________________________________    CH.sub.3  H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            CH.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             (CH.sub.2).sub.2 CH.sub.3                                                               H      H  Cl   OCH.sub.3                                                                            CH                                            OCH.sub.3 H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             OCH.sub.2 CH.sub.3                                                                      H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             O(CH.sub.2).sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            Cl        H      H  Cl   OCH.sub.3                                                                            CH                                            Cl        6-Cl   H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            NO.sub.2  H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CF.sub.3  H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       H      CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       3-CH.sub.3                                                                           H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       5-CH.sub.3                                                                           H  Cl   OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       5-Cl   H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       5-OCH.sub.3                                                                          H  OCH.sub.3                                                                          OCH.sub. 3                                                                           N                                             CO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.2 CH.sub.3                                                              5-F    H  Cl   OCH.sub.3                                                                            CH                                            CO.sub.2 CH(CH.sub.3).sub.2                                                             H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            Br        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH 160-165(d)                                 SO.sub.2 N(CH.sub.3).sub.2                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             SO.sub.2 N(CH.sub.3).sub.2                                                              H      CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              5-Cl   H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 N(OCH.sub.3)CH.sub.3                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             OSO.sub.2 CH.sub.3                                                                      H      H  Cl   OCH.sub.3                                                                            CH                                            OSO.sub.2 CH.sub.2 CH.sub.3                                                             H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                      H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH 135-145(d)                                 SO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             OCHF.sub.2                                                                              H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             5-methyl-1,3,4-                                                                         H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            oxadiazol-2-yl                                                                5-methyl-1,3,4-                                                                         H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             oxadiazol-2-yl                                                                1,2,3-thiadiazol-                                                                       H      H  CH.sub.3                                                                           OCH.sub. 3                                                                           N                                             4-yl                                                                          1,2,3-thiadiazol-                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            4-yl                                                                          CO.sub.2 CH.sub.2 CH═CH.sub.2                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            Cl        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH 157-162(d)                                 Cl        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N  103-106                                    Cl        H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N  235-240(d)                                 Cl        H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N  195-202(d)                                 SO.sub.2 CH.sub.3                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N  158-161                                    SCH.sub.3 H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH 168-172                                    OCHFCHF.sub.2                                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SCF.sub.3 5-Cl   H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            SCH.sub.2 CCl.sub.3                                                                     H      H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             SO.sub.2 CH.sub.2 CH.sub.2 Br                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            COCH.sub.2 CH.sub.3                                                                     5-SCH.sub.3                                                                          H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            S(O)CH.sub.3                                                                            H      H  Cl   OCH.sub.3                                                                            CH                                            CH.sub.2 OCF.sub.3                                                                      H      H  Cl   OCH.sub.3                                                                            CH                                            2-methyl-isoxa-                                                                         H      H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             zol-4-yl                                                                      2-methyl-iso-                                                                           H      H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            thiazol-4-yl                                                                  isothiazol-5-yl                                                                         H      CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             5-methyl-iso-                                                                           H      H  Cl   OCH.sub.3                                                                            CH                                            thiazol-2-yl                                                                  CO.sub.2 CH.sub.3                                                                       5-CH.sub.2 CH.sub.3                                                                  H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            CO.sub.2 CH.sub.3                                                                       5-CH.sub.2 OCH.sub.3                                                                 H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            Cl        6-SCH.sub.3                                                                          H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          CH.sub.2 S(O)CH.sub.3                                                                CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              5-OCF.sub.3                                                                          H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            Cl        5-CH.sub.2 SCH.sub.3                                                                 H  Cl   OCH.sub.3                                                                            CH                                            Cl        5-OCH.sub.2 CHF.sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             Cl        H      H  OCF.sub.2 H                                                                        NH.sub.2                                                                             CH                                            Cl        H      H  OCH.sub.3                                                                          CH.sub.2 SO.sub.2 CH.sub.3                                                           N                                             Cl        H      H  OCH.sub.3                                                                          C.tbd.CH                                                                             N                                             Cl        H      H  OCH.sub.3                                                                          C.tbd.CCH.sub.3                                                                      N                                             __________________________________________________________________________

                                      TABLE 2                                     __________________________________________________________________________    General Structure 2                                                           R.sub.2   R.sub.3                                                                            R  X    Y   Z  m.p. (°C.)                               __________________________________________________________________________    CH.sub.3  H    H  CH.sub.3                                                                           OCH.sub.3                                                                         CH                                                 CH.sub.2 CH.sub.3                                                                       H    H  OCH.sub.3                                                                          OCH.sub.3                                                                         N                                                  (CH.sub.2).sub.2 CH.sub.3                                                               H    H  Cl   OCH.sub.3                                                                         CH                                                 OCH.sub.3 H    H  CH.sub.3                                                                           OCH.sub.3                                                                         N                                                  OCH.sub.2 CH.sub.3                                                                      H    H  OCH.sub.3                                                                          OCH.sub.3                                                                         N                                                  O(CH.sub.2).sub.2 CH.sub.3                                                              H    H  CH.sub.3                                                                           OCH.sub.3                                                                         CH                                                 Cl        H    H  Cl   OCH.sub.3                                                                         CH 156-159                                         Cl        6-Cl H  OCH.sub.3                                                                          OCH.sub.3                                                                         CH                                                 NO.sub.2  H    H  CH.sub.3                                                                           OCH.sub.3                                                                         N                                                  CF.sub.3  H    H  OCH.sub.3                                                                          OCH.sub.3                                                                         CH                                                 CO.sub.2 CH.sub.3                                                                       H    H  CH.sub.3                                                                           OCH.sub.3                                                                         N                                                  CO.sub.2 CH.sub.3                                                                       H    CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                         N                                                  CO.sub.2 CH.sub.3                                                                       3-CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                         CH                                                 CO.sub.2 CH.sub.3                                                                       5-CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                         CH                                                 CO.sub.2 CH.sub.3                                                                       5-Cl H  CH.sub.3                                                                           OCH.sub.3                                                                         N                                                  CO.sub.2 CH.sub.3                                                                       5-OCH.sub.3                                                                        H  OCH.sub. 3                                                                         OCH.sub.3                                                                         N                                                  CO.sub.2 CH.sub.2 CH.sub.3                                                              H    H  CH.sub.3                                                                           OCH.sub.3                                                                         CH                                                 CO.sub.2 CH.sub.2 CH.sub.3                                                              5-F  H  Cl   OCH.sub.3                                                                         CH                                                 CO.sub.2 CH(CH.sub.3).sub.2                                                             H    H  OCH.sub.3                                                                          OCH.sub.3                                                                         CH                                                 Br        H    H  OCH.sub.3                                                                          OCH.sub.3                                                                         CH 120-125                                                                       (Amorphous)                                     SO.sub.2 N(CH.sub.3).sub.2                                                              H    H  CH.sub.3                                                                           OCH.sub.3                                                                         N                                                  SO.sub.2 N(CH.sub.3).sub.2                                                              H    CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                         CH                                                 SO.sub.2 N(CH.sub.3).sub.2                                                              5-Cl H  CH.sub.3                                                                           OCH.sub.3                                                                         CH                                                 SO.sub.2 N(OCH.sub.3)CH.sub.3                                                           H    H  OCH.sub.3                                                                          OCH.sub.3                                                                         N                                                  OSO.sub.2 CH.sub.3                                                                      H    H  Cl   OCH.sub.3                                                                         CH                                                 OSO.sub.2 CH.sub.2 CH.sub.3                                                             H    H  OCH.sub.3                                                                          OCH.sub.3                                                                         N                                                  SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                      H    H  CH.sub.3                                                                           OCH.sub.3                                                                         CH                                                 SO.sub.2 CH.sub.3                                                                       H    H  OCH.sub.3                                                                          OCH.sub.3                                                                         CH                                                 SO.sub.2 CH.sub.2 CH.sub.3                                                              H    H  CH.sub.3                                                                           OCH.sub.3                                                                         N                                                  OCHF.sub.2                                                                              H    H  OCH.sub.3                                                                          OCH.sub.3                                                                         N                                                  5-methyl-1,3,4-                                                                         H    H  CH.sub.3                                                                           OCH.sub.3                                                                         CH                                                 oxadiazol-2-yl                                                                5-methyl-1,3,4-                                                                         H    H  OCH.sub.3                                                                          OCH.sub.3                                                                         N                                                  oxadiazol-2-yl                                                                1,2,3-thiadiazol-                                                                       H    H  CH.sub.3                                                                           OCH.sub.3                                                                         N                                                  4-yl                                                                          1,2,3-thiadiazol-                                                                       H    H  OCH.sub.3                                                                          OCH.sub.3                                                                         CH                                                 4-yl                                                                          CO.sub.2 CH.sub.2 CH═CH.sub.2                                                       H    H  CH.sub.3                                                                           OCH.sub.3                                                                         CH                                                 Cl        H    H  CH.sub.3                                                                           OCH.sub.3                                                                         N  154-160                                         Cl        H    H  OCH.sub.3                                                                          OCH.sub.3                                                                         N  181-187                                         Cl        H    H  OCH.sub.3                                                                          OCH.sub.3                                                                         CH 150-157                                         Cl        6-OCHF.sub.2                                                                       H  CH.sub.3                                                                           CH.sub.3                                                                          CH                                                 SCCl.sub.3                                                                              H    H  OCH.sub.3                                                                          CH.sub.3                                                                          N                                                  SCH.sub.3 H    H  OCH.sub.3                                                                          OCH.sub.3                                                                         CH                                                 COCH.sub.3                                                                              5-Cl H  CH.sub.3                                                                           OCH.sub.3                                                                         N                                                  CH.sub.2 OCF.sub.3                                                                      5-OCF.sub.3                                                                        H  Cl   OCH.sub.3                                                                         CH                                                 2-methyl-isoxa-                                                                         H    H  OCH.sub.3                                                                          OCH.sub.3                                                                         N                                                  zoyl-4-yl                                                                     __________________________________________________________________________

                                      TABLE 3                                     __________________________________________________________________________    General Structure 3                                                           R.sub.2   R.sub.3                                                                              R  X    Y      Z  m.p. (°C.)                          __________________________________________________________________________    CH.sub.3  H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            CH.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             (CH.sub.2).sub.2 CH.sub.3                                                               H      H  Cl   OCH.sub.3                                                                            CH                                            OCH.sub.3 H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             OCH.sub.2 CH.sub.3                                                                      H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             O(CH.sub.2).sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            Cl        H      H  Cl   OCH.sub.3                                                                            CH                                            Cl        6-Cl   H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            NO.sub.2  H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CF.sub.3  H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       H      CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       3-CH.sub.3                                                                           H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       5-CH.sub.3                                                                           H  Cl   OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       5-Cl   H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       5-OCH.sub.3                                                                          H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.2 CH.sub.3                                                              5-F    H  Cl   OCH.sub.3                                                                            CH                                            CO.sub.2 CH(CH.sub.3).sub.2                                                             H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            Br        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             SO.sub.2 N(CH.sub.3).sub.2                                                              H      CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              5-Cl   H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 N(OCH.sub.3)CH.sub.3                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             OSO.sub.2 CH.sub.3                                                                      H      H  Cl   OCH.sub.3                                                                            CH                                            OSO.sub.2 CH.sub.2 CH.sub.3                                                             H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                      H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             OCHF.sub.2                                                                              H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             5-methyl-1,3,4-                                                                         H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            oxadiazol-2-yl                                                                5-methyl-1,3,4-                                                                         H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             oxadiazol-2-yl                                                                1,2,3-thiadiazol-                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             4-yl                                                                          1,2,3-thiadiazol-                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            4-yl                                                                          CO.sub.2 CH.sub.2 CH═CH.sub.2                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            Cl        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            Cl        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             Cl        H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             Cl        H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SO.sub.2 CH.sub.3                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             SCH.sub.3 H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            OCHFCHF.sub.2                                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SCF.sub.3 5-Cl   H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            SCH.sub.2 CCl.sub.3                                                                     H      H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             SO.sub.2 CH.sub.2 CH.sub.2 Br                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            COCH.sub.2 CH.sub.3                                                                     5-SCH.sub.3                                                                          H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            S(O)CH.sub.3                                                                            H      H  Cl   OCH.sub.3                                                                            CH                                            CH.sub.2 OCF.sub.3                                                                      H      H  Cl   OCH.sub.3                                                                            CH                                            2-methyl-isoxa-                                                                         H      H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             zol-4-yl                                                                      2-methyl-iso-                                                                           H      H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            thiazol-4-yl                                                                  isothiazol-5-yl                                                                         H      CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             5-methyl-iso-                                                                           H      H  Cl   OCH.sub.3                                                                            CH                                            thiazol-2-yl                                                                  CO.sub.2 CH.sub.3                                                                       5-CH.sub.2 CH.sub.3                                                                  H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            CO.sub.2 CH.sub.3                                                                       5-CH.sub.2 OCH.sub.3                                                                 H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            Cl        6-SCH.sub.3                                                                          H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          CH.sub.2 S(O)CH.sub.3                                                                CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              5-OCF.sub.3                                                                          H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            Cl        5-CH.sub.2 SCH.sub.3                                                                 H  Cl   OCH.sub.3                                                                            CH                                            Cl        5-OCH.sub.2 CHF.sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             Cl        H      H  OCF.sub.2 H                                                                        NH.sub.2                                                                             CH                                            Cl        H      H  OCH.sub.3                                                                          CH.sub.2 SO.sub.2 CH.sub.3                                                           N                                             Cl        H      H  OCH.sub.3                                                                          C.tbd.CH                                                                             N                                             Cl        H      H  OCH.sub.3                                                                          C.tbd.CCH.sub.3                                                                      N                                             __________________________________________________________________________

                                      TABLE 4                                     __________________________________________________________________________    General Structure 4                                                           R.sub.2   R.sub.3                                                                              R  X    Y      Z  m.p. (°C.)                          __________________________________________________________________________    CH.sub.3  H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            CH.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             (CH.sub.2).sub.2 CH.sub.3                                                               H      H  Cl   OCH.sub.3                                                                            CH                                            OCH.sub.3 H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             OCH.sub.2 CH.sub.3                                                                      H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             O(CH.sub.2).sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            Cl        H      H  Cl   OCH.sub.3                                                                            CH                                            Cl        6-Cl   H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            NO.sub.2  H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CF.sub.3  H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       H      CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       3-CH.sub.3                                                                           H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       5-CH.sub.3                                                                           H  Cl   OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       5-Cl   H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       5-OCH.sub.3                                                                          H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.2 CH.sub.3                                                              5-F    H  Cl   OCH.sub.3                                                                            CH                                            CO.sub.2 CH(CH.sub.3).sub.2                                                             H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            Br        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             SO.sub.2 N(CH.sub.3).sub.2                                                              H      CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              5-Cl   H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 N(OCH.sub.3)CH.sub.3                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             OSO.sub.2 CH.sub.3                                                                      H      H  Cl   OCH.sub.3                                                                            CH                                            OSO.sub.2 CH.sub.2 CH.sub.3                                                             H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                      H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             OCHF.sub.2                                                                              H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             5-methyl-1,3,4-                                                                         H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            oxadiazol-2-yl                                                                5-methyl-1,3,4-                                                                         H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             oxadiazol-2-yl                                                                1,2,3-thiadiazol-                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             4-yl                                                                          1,2,3-thiadiazol-                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            4-yl                                                                          CO.sub.2 CH.sub.2 CH═CH.sub.2                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            Cl        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            Cl        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             Cl        H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             Cl        H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SO.sub.2 CH.sub.3                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             SCH.sub.3 H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            OCHFCHF.sub.2                                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SCF.sub.3 5-Cl   H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            SCH.sub.2 CCl.sub.3                                                                     H      H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             SO.sub.2 CH.sub.2 CH.sub.2 Br                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            COCH.sub.2 CH.sub.3                                                                     5-SCH.sub.3                                                                          H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            S(O)CH.sub.3                                                                            H      H  Cl   OCH.sub.3                                                                            CH                                            CH.sub.2 OCF.sub.3                                                                      H      H  Cl   OCH.sub.3                                                                            CH                                            2-methyl-isoxa-                                                                         H      H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             zol-4-yl                                                                      2-methyl-iso-                                                                           H      H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            thiazol-4-yl                                                                  isothiazol-5-yl                                                                         H      CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             5-methyl-iso-                                                                           H      H  Cl   OCH.sub.3                                                                            CH                                            thiazol-2-yl                                                                  CO.sub.2 CH.sub.3                                                                       5-CH.sub.2 CH.sub.3                                                                  H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            CO.sub.2 CH.sub.3                                                                       5-CH.sub.2 OCH.sub.3                                                                 H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            Cl        6-SCH.sub.3                                                                          H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          CH.sub.2 S(O)CH.sub.3                                                                CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              5-OCF.sub.3                                                                          H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            Cl        5-CH.sub.2 SCH.sub.3                                                                 H  Cl   OCH.sub.3                                                                            CH                                            Cl        5-OCH.sub.2 CHF.sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             Cl        H      H  OCF.sub.2 H                                                                        NH.sub.2                                                                             CH                                            Cl        H      H  OCH.sub.3                                                                          CH.sub.2 SO.sub.2 CH.sub.3                                                           N                                             Cl        H      H  OCH.sub.3                                                                          C.tbd.CH                                                                             N                                             Cl        H      H  OCH.sub.3                                                                          C.tbd.CCH.sub.3                                                                      N                                             __________________________________________________________________________

                                      TABLE 5                                     __________________________________________________________________________    General Structure 5                                                           R.sub.2   R.sub.3                                                                              R  X    Y      Z  m.p. (°C.)                          __________________________________________________________________________    CH.sub.3  H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            CH.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             (CH.sub.2).sub.2 CH.sub.3                                                               H      H  Cl   OCH.sub.3                                                                            CH                                            OCH.sub.3 H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             OCH.sub.2 CH.sub.3                                                                      H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             O(CH.sub.2).sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            Cl        H      H  Cl   OCH.sub.3                                                                            CH                                            Cl        6-Cl   H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            NO.sub.2  H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CF.sub.3  H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       H      CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       3-CH.sub.3                                                                           H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       5-CH.sub.3                                                                           H  Cl   OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       5-Cl   H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       5-OCH.sub.3                                                                          H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.2 CH.sub.3                                                              5-F    H  Cl   OCH.sub.3                                                                            CH                                            CO.sub.2 CH(CH.sub.3).sub.2                                                             H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            Br        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             SO.sub.2 N(CH.sub.3).sub.2                                                              H      CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              5-Cl   H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 N(OCH.sub.3)CH.sub.3                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             OSO.sub.2 CH.sub.3                                                                      H      H  Cl   OCH.sub.3                                                                            CH                                            OSO.sub.2 CH.sub.2 CH.sub.3                                                             H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                      H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             OCHF.sub.2                                                                              H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             5-methyl-1,3,4-                                                                         H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            oxadiazol-2-yl                                                                5-methyl-1,3,4-                                                                         H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             oxadiazol-2-yl                                                                1,2,3-thiadiazol-                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             4-yl                                                                          1,2,3-thiadiazol-                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            4-yl                                                                          CO.sub.2 CH.sub.2 CH═CH.sub.2                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            Cl        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            Cl        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             Cl        H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             Cl        H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SO.sub.2 CH.sub.3                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             SCH.sub.3 H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            OCHFCHF.sub.2                                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SCF.sub.3 5-Cl   H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            SCH.sub.2 CCl.sub.3                                                                     H      H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             SO.sub.2 CH.sub.2 CH.sub.2 Br                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            COCH.sub.2 CH.sub.3                                                                     5-SCH.sub.3                                                                          H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            S(O)CH.sub.3                                                                            H      H  Cl   OCH.sub.3                                                                            CH                                            CH.sub.2 OCF.sub.3                                                                      H      H  Cl   OCH.sub.3                                                                            CH                                            2-methyl-isoxa-                                                                         H      H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             zol-4-yl                                                                      2-methyl-iso-                                                                           H      H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            thiazol-4-yl                                                                  isothiazol-5-yl                                                                         H      CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             5-methyl-iso-                                                                           H      H  Cl   OCH.sub.3                                                                            CH                                            thiazol-2-yl                                                                  CO.sub.2 CH.sub.3                                                                       5-CH.sub.2 CH.sub.3                                                                  H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            CO.sub.2 CH.sub.3                                                                       5-CH.sub.2 OCH.sub.3                                                                 H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            Cl        6-SCH.sub.3                                                                          H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          CH.sub.2 S(O)CH.sub.3                                                                CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              5-OCF.sub.3                                                                          H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            Cl        5-CH.sub.2 SCH.sub.3                                                                 H  Cl   OCH.sub.3                                                                            CH                                            Cl        5-OCH.sub.2 CHF.sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             Cl        H      H  OCF.sub.2 H                                                                        NH.sub.2                                                                             CH                                            Cl        H      H  OCH.sub.3                                                                          CH.sub.2 SO.sub.2 CH.sub.3                                                           N                                             Cl        H      H  OCH.sub.3                                                                          C.tbd.CH                                                                             N                                             Cl        H      H  OCH.sub.3                                                                          C.tbd.CCH.sub.3                                                                      N                                             __________________________________________________________________________

                                      TABLE 6                                     __________________________________________________________________________    General Structure 6                                                           R.sub.1   R.sub.2       R.sub.3                                                                            R  X      Y              Z  m.p.                 __________________________________________________________________________                                                             (°C.)         (CH.sub.2).sub.2 CH.sub.3                                                               SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             OCH.sub.3      CH                      CH.sub.2 CH.sub.2 F                                                                     CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            OCH.sub.3      CH                      CH.sub.2 CH.sub.2 F                                                                     SO.sub.2 CH.sub.3                                                                           H    H  Cl     OCH.sub.3      CH                      CH.sub.2 CH.sub.2 CH.sub.2 F                                                            SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             OCH.sub.3      N                       CH.sub.2 CH.sub.2 CH.sub.2 F                                                            CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    H  OCH.sub.3                                                                            OCH.sub.3      N                       CH.sub.2 CH.sub.2 CF.sub.3                                                              SO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                             OCH.sub.3      CH                      CH.sub.2 CHFCH.sub.2 F                                                                  SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                            OCH.sub.3      CH                      CH.sub.2 CH.sub.2 OCH.sub.3                                                             CO.sub.2 CH.sub.3                                                                           H    H  Cl     OCH.sub.3      CH                      CH.sub.2 CH.sub.2 OH                                                                    SO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                             OCH.sub.3      N                       CH.sub.2 CH.sub.2 OSi(CH.sub.3 ).sub.3                                                  SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                            OCH.sub.3      N                       OH        SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             OCH.sub.3      CH                      OSi(CH.sub.3).sub.3                                                                     CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            OCH.sub.3      CH                      OCH.sub.3 SO.sub.2 CH.sub.3                                                                           H    H  Cl     OCH.sub.3      CH                      OCH.sub.2 CH.sub.3                                                                      SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             OCH.sub.3      N                       SO.sub.2 CH.sub.3                                                                       CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            OCH.sub.3      N                       C.sub.6 H.sub.5                                                                         SO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                             OCH.sub.3      CH                      CH.sub.2 C.sub.6 H.sub.5                                                                SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                            OCH.sub.3      CH                      OCH.sub.3 CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3      CH                      SO.sub.2 CH.sub.3                                                                       SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             OCH.sub.3      N                       CH.sub.2 C.sub.6 H.sub.5                                                                CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            OCH.sub.3      N                       OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             CH.sub.3       CH                      SO.sub.2 CH.sub.3                                                                       SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            N(CH.sub.3).sub.                                                                             N                       CH.sub.3  (CH.sub.2).sub.3 CH.sub.3                                                                   H    H  CH.sub.3                                                                             OCH.sub.3      CH                      H         (CH.sub.2).sub.3 CH.sub.3                                                                   H    H  OCH.sub.3                                                                            OCH.sub.3      N                       CH.sub.3  O(CH.sub.2).sub.3 CH.sub.3                                                                  H    H  CH.sub.3                                                                             OCH.sub.3      N                       H         O(CH.sub.2).sub.3 CH.sub.3                                                                  H    H  OCH.sub.3                                                                            OCH.sub.3      CH                      CH.sub.3  OCH.sub.2 CH.sub.2 OCH.sub.3                                                                H    H  CH.sub.3                                                                             OCH.sub.3      N                       H         OCH.sub.2 CH.sub.2 OCH.sub.3                                                                H    H  OCH.sub.3                                                                            OCH.sub.3      CH                      CH.sub.3  F             H    H  CH.sub.3                                                                             OCH.sub.3      CH                      H         F             H    H  OCH.sub.3                                                                            OCH.sub.3      N                       CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                          H    H  CH.sub.3                                                                             OCH.sub.3      N                       H         CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                          H    H  OCH.sub.3                                                                            OCH.sub.3      CH                      CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                        H    H  CH.sub.3                                                                             OCH.sub.3      CH                      H         CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                        H    H  OCH.sub.3                                                                            OCH.sub.3      N                       CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                               H    H  CH.sub.3                                                                             OCH.sub.3      CH                      H         CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                               H    H  OCH.sub.3                                                                            OCH.sub.3      N                       CH.sub.3  OCF.sub.3     H    H  OCH.sub.3                                                                            OCH.sub.3      N                       H         OCF.sub.3     H    H  CH.sub.3                                                                             OCH.sub.3      CH                      CH.sub.3  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                         H    H  OCH.sub.3                                                                            OCH.sub.3      CH                      H         SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                         H    H  CH.sub.3                                                                             OCH.sub.3      N                       CH.sub.3  SO.sub.2 N(CH.sub.3)(CH.sub.2).sub.2 CH.sub.3                                               H    H  OCH.sub.3                                                                            OCH.sub.3      N                       H         SO.sub.2 N(CH.sub.3)(CH.sub.2).sub.2 CH.sub.3                                               H    H  CH.sub.3                                                                             OCH.sub.3      CH                      CH.sub.3  OSO.sub.2 N(CH.sub.3).sub.2                                                                 H    H  CH.sub.3                                                                             OCH.sub.3      CH                      H         OSO.sub.2 N(CH.sub.3).sub.2                                                                 H    H  OCH.sub.3                                                                            OCH.sub.3      N                       CH.sub.3  OSO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                         H    H  CH.sub.3                                                                             OCH.sub.3      N                       H         OSO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                         H    H  OCH.sub.3                                                                            OCH.sub.3      CH                      CH.sub.3  SO.sub.2 CH.sub.2 CH═CH.sub.2                                                           H    H  CH.sub.3                                                                             OCH.sub.3      CH                      H         SO.sub.2 CH.sub.2 CH═CH.sub.2                                                           H    H  OCH.sub.3                                                                            OCH.sub.3      N                       CH.sub.3  SCF.sub.3     H    H  OCH.sub.3                                                                            OCH.sub.3      N                       H         SCF.sub.3     H    H  CH.sub.3                                                                             OCH.sub.3      CH                      CH.sub.3  SO.sub.2 CF.sub.3                                                                           H    H  CH.sub.3                                                                             OCH.sub.3      CH                      H         SO.sub.2 CF.sub.3                                                                           H    H  OCH.sub.3                                                                            OCH.sub.3      N                       CH.sub.3  SCF.sub.2 H   H    H  CH.sub.3                                                                             OCH.sub.3      N                       H         SCF.sub.2 H   H    H  Cl     OCH.sub.3      CH                      CH.sub.3  SO.sub.2 CF.sub.2 H                                                                         H    H  OCH.sub.3                                                                            OCH.sub.3      CH                      H         SO.sub.2 CF.sub.2 H                                                                         H    H  CH.sub.3                                                                             OCH.sub.3      N                       CH.sub.3  OCH.sub.2 CH═CH.sub.2                                                                   H    H  CH.sub.3                                                                             OCH.sub.3      N                       H         OCH.sub.2 CH═CH.sub.2                                                                   H    H  OCH.sub.3                                                                            OCH.sub.3      CH                      CH.sub.3  OCH.sub.2 CH═CHCH.sub.3                                                                 H    H  CH.sub.3                                                                             OCH.sub.3      CH                      H         OCH.sub.2 CH═CHCH.sub.3                                                                 H    H  OCH.sub.3                                                                            OCH.sub.3      N                       CH.sub.3  OCH.sub.2 C.tbd.CH                                                                          H    H  OCH.sub.3                                                                            OCH.sub.3      N                       H         OCH.sub.2 C.tbd.CH                                                                          H    H  CH.sub.3                                                                             OCH.sub.3      CH                      CH.sub.3  OCH.sub.2 C.tbd.CCH.sub.3                                                                   H    H  OCH.sub.3                                                                            OCH.sub.3      CH                      H         OCH.sub.2 C.tbd.CCH.sub.3                                                                   H    H  CH.sub.3                                                                             OCH.sub.3      N                       CH.sub.3  CH.sub.2 OCH.sub.3                                                                          H    H  CH.sub.3                                                                             OCH.sub.3      N                       H         CH.sub.2 OCH.sub.3                                                                          H    H  OCH.sub.3                                                                            OCH.sub.3      CH                      CH.sub.3  CH.sub.2 OCH.sub.2 CH.sub.3                                                                 H    H  CH.sub.3                                                                             OCH.sub.3      CH                      H         CH.sub.2 OCH.sub.2 CH.sub.3                                                                 H    H  OCH.sub.3                                                                            OCH.sub.3      N                       CH.sub.3  (CH.sub.2).sub.2 OCH.sub.3                                                                  H    H  CH.sub.3                                                                             OCH.sub.3      CH                      H         (CH.sub.2).sub.2 OCH.sub.3                                                                  H    H  OCH.sub.3                                                                            OCH.sub.3      N                       CH.sub.3  (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3                                                         H    H  CH.sub.3                                                                             OCH.sub.3      N                       H         (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3                                                         H    H  OCH.sub.3                                                                            OCH.sub.3      CH                      CH.sub.3  C.sub.6 H.sub.5                                                                             H    H  CH.sub.3                                                                             OCH.sub.3      CH                      H         C.sub.6 H.sub.5                                                                             H    H  OCH.sub.3                                                                            OCH.sub.3      N                       CH.sub.3  1,3,4,oxadiazol-2-yl                                                                        H    H  OCH.sub.3                                                                            OCH.sub.3      N                       H         1,3,4-oxadiazol-2-yl                                                                        H    H  CH.sub.3                                                                             OCH.sub.3      CH                      CH.sub.3  5-isoxazolyl  H    H  OCH.sub.3                                                                            OCH.sub.3      CH                      H         5-isoxazolyl  H    H  CH.sub.3                                                                             OCH.sub.3      N                       CH.sub.3  3-isoxazolyl  H    H  CH.sub.3                                                                             OCH.sub.3      N                       H         3-isoxazolyl  H    H  OCH.sub.3                                                                            OCH.sub.3      CH                      CH.sub.3  4-isoxazolyl  H    H  CH.sub.3                                                                             OCH.sub.3      CH                      H         4-isoxazolyl  H    H  OCH.sub.3                                                                            OCH.sub.3      N                       CH.sub.3  1-methyl-1H--pyrazol-3-yl                                                                   H    H  OCH.sub.3                                                                            OCH.sub.3      N                       H         1-methyl-1H--pyrazol-3-yl                                                                   H    H  CH.sub.3                                                                             OCH.sub.3      CH                      CH.sub.3  1H--pyrazol-1-yl                                                                            H    H  OCH.sub.3                                                                            OCH.sub.3      CH                      H         1H--pyrazol-1-yl                                                                            H    H  CH.sub.3                                                                             OCH.sub.3      N                       CH.sub.3  1H--1,2,4-triazol-1-yl                                                                      H    H  CH.sub.3                                                                             OCH.sub.3      N                       H         1H--1,2,4-triazol-1-yl                                                                      H    H  OCH.sub.3                                                                            OCH.sub.3      CH                      CH.sub.3  tetrahydro-2-furanyl                                                                        H    H  CH.sub.3                                                                             OCH.sub.3      CH                      H         tetrahydro-2-furanyl                                                                        H    H  OCH.sub.3                                                                            OCH.sub.3      N                       CH.sub.3  2-furanyl     H    H  CH.sub.3                                                                             OCH.sub.3      N                       H         2-furanyl     H    H  OCH.sub.3                                                                            OCH.sub.3      CH                      CH.sub.3  2-thienyl     H    H  CH.sub.3                                                                             OCH.sub.3      CH                      H         2-thienyl     H    H  OCH.sub.3                                                                            OCH.sub.3      N                       CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                  5-F  H  CH.sub.3                                                                             OCH.sub.3      N                       H         CO.sub.2 CH.sub.3                                                                           3-F  H  OCH.sub.3                                                                            OCH.sub.3      CH                      CH.sub.3  CO.sub.2 CH.sub.3                                                                           3-Cl H  OCH.sub.3                                                                            OCH.sub.3      CH                      H         OCF.sub.2 H   6-Cl H  CH.sub.3                                                                             OCH.sub.3      N                       CH.sub.3  SO.sub.2 CH.sub.3                                                                           6-Br H  CH.sub.3                                                                             OCH.sub.3      N                       H         SO.sub.2 N(CH.sub.3).sub.2                                                                  5-Br H  OCH.sub.3                                                                            OCH.sub.3      CH                      CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                  5-CF.sub.3                                                                         H  OCH.sub.3                                                                            OCH.sub.3      CH                      H         Cl            6-CF.sub.3                                                                         H  CH.sub.3                                                                             OCH.sub.3      N                       CH.sub.3  OSO.sub.2 CH.sub.3                                                                          6-CH.sub.3                                                                         H  OCH.sub.3                                                                            OCH.sub.3      N                       H         SO.sub.2 N(CH.sub.3).sub.2                                                                  5-CH.sub.3                                                                         H  CH.sub.3                                                                             OCH.sub.3      CH                      CH.sub.3  SO.sub.2 CH.sub.3                                                                           3-OCH.sub.3                                                                        H  OCH.sub.3                                                                            OCH.sub.3      CH                      H         CO.sub.2 CH.sub.3                                                                           5-OCH.sub.3                                                                        H  CH.sub.3                                                                             OCH.sub.3      N                       CH.sub.3  SO.sub.2 CH.sub.3                                                                           6-OCF.sub.2 H                                                                      H  CH.sub.3                                                                             OCH.sub.3      N                       H         SO.sub.2 N(CH.sub.3).sub.2                                                                  5-OCF.sub.2 H                                                                      H  OCH.sub.3                                                                            OCH.sub.3      CH                      CH.sub.3  CO.sub.2 CH.sub.3                                                                           5-OC.sub.2 H.sub.5                                                                 H  CH.sub.3                                                                             OCH.sub.3      CH                      H         SO.sub.2 N(CH.sub.3).sub.2                                                                  6-OC.sub.2 H.sub.5                                                                 H  OCH.sub.3                                                                            OCH.sub.3      N                       CH.sub.3  OCH.sub.2 CH.sub.3                                                                          6-Cl CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3      N                       H         SO.sub.2 N(CH.sub.3).sub.2                                                                  5-OCH.sub.3                                                                        CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3      CH                      CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    H  CH.sub.3                                                                             CH.sub.3       CH                      H         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                            OC.sub.2 H.sub.5                                                                             N                       CH.sub.3  SO.sub.2 CH.sub.3                                                                           H    H  OC.sub.2 H.sub.5                                                                     CH.sub.3       N                       H         OSO.sub.2 CH.sub.3                                                                          H    H  OC.sub.2 H.sub.5                                                                     OC.sub.2 H.sub.5                                                                             CH                      CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  Cl     OCH.sub.3      CH                      H         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  Cl     OC.sub.2 H.sub.5                                                                             CH                      CH.sub.3  SO.sub.2 CH.sub.3                                                                           H    H  F      OCH.sub.3      CH                      H         SO.sub.2 N(OCH.sub.3)CH.sub.3                                                               H    H  F      OCH.sub.3      CH                      CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  Br     OCH.sub.3      CH                      H         OSO.sub.2 CH.sub.3                                                                          H    H  Br     OCH.sub.3      CH                      CH.sub.3  NO.sub.2      H    H  I      OCH.sub.3      CH                      H         CO.sub.2 CH.sub.3                                                                           H    H  I      OCH.sub.3      CH                      CH.sub.3  SO.sub.2 CH.sub.3                                                                           H    H  OCF.sub.2 H                                                                          CH.sub.3       CH                      H         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCF.sub.2 H                                                                          OCF.sub.2 H    CH                      CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  CH.sub.2 F                                                                           CH.sub.3       N                       H         Cl            6-Cl H  CH.sub.2 F                                                                           OCH.sub.3      CH                      CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub. 2 CH.sub.2 F                                                                OCH.sub.3      CH                      H         SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.2 CH.sub.2 F                                                                 CH.sub.3       N                       CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    H  OCH.sub.2 CHF.sub.2                                                                  CH.sub.3       N                       H         NO.sub.2      H    H  OCH.sub.2 CHF.sub.2                                                                  OCH.sub.3      CH                      CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.3      CH                      H         OSO.sub.2 CH.sub.3                                                                          H    H  OCH.sub.2 CF.sub.3                                                                   CH.sub.3       N                       CH.sub.3  SO.sub.2 CH.sub.3                                                                           H    H  CF.sub.3                                                                             CH.sub.3       CH                      H         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CF.sub.3                                                                             OCH.sub.3      CH                      CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            H              CH                      CH.sub.3  NO.sub.2      H    H  CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                             N                       CH.sub.3  OSO.sub.2 CH.sub.3                                                                          H    H  OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                           N                       H         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                           CH                      CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                             CH.sub.2 OCH.sub.2 CH.sub.3                                                                  CH                      H         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                            CH.sub.2 OCH.sub.2 CH.sub.3                                                                  N                       CH.sub.3  SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            NHCH.sub.3     N                       H         OSO.sub.2 CH.sub.3                                                                          H    H  OCH.sub.3                                                                            NHCH.sub.3     CH                      CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            N(OCH.sub.3)CH.sub.3                                                                         N                       H         SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            N(CH.sub.3).sub.2                                                                            N                       CH.sub.3  NO.sub.2      H    H  OCH.sub.3                                                                            N(CH.sub.3).sub.2                                                                            CH                      H         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             C.sub.2 H.sub.5                                                                              CH                      CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    H  OCH.sub.3                                                                            C.sub.2 H.sub.5                                                                              N                       H         SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            CF.sub.3       N                       CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                             CF.sub.3       CH                      H         OSO.sub.2 CH.sub.3                                                                          H    H  CH.sub.3                                                                             SCH.sub.3      CH                      CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                            SCH.sub.3      N                       H         CO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                             OCH.sub.2 C.tbd.CH                                                                           N                       CH.sub.3  SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            OCH.sub.2 C.tbd.CH                                                                           CH                      H         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                            OCH.sub.2 CH═CH.sub.2                                                                    CH                      CH.sub.3  NO.sub.2      H    H  CH.sub.3                                                                             OCH.sub.2 CH═CH.sub.2                                                                    N                       H         OSO.sub.2 CH.sub.3                                                                          H    H  OCH.sub.3                                                                            OCH.sub.2 CH.sub.2 OCH.sub.3                                                                 N                       CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                             OCH.sub.2 CH.sub.2 OCH.sub.3                                                                 CH                      H         SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            CH.sub.2 SCH.sub.3                                                                           CH                      CH.sub.3  NO.sub.2      H    H  OCH.sub.3                                                                            CH.sub.2 SCH.sub.3                                                                           N                       CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             OCF.sub.2 H    CH                      CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            SCF.sub.2 H    CH                      H         SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            SCF.sub.2 H    N                       CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            cyclopropyl    N                       H         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                            cyclopropyl    CH                      CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            dimethoxymethyl                                                                              N                       H         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             dimethoxymethyl                                                                              CH                      CH.sub.3  SO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                             ethoxymethoxymethyl                                                                          CH                      H         NO.sub.2      H    H  OCH.sub.3                                                                            ethoxymethoxymethyl                                                                          CH                      CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    H  CH.sub.3                                                                             diethoxymethyl CH                      H         OSO.sub. 2 CH.sub.3                                                                         H    H  OCH.sub.3                                                                            diethoxymethyl CH                      CH.sub.3  SO.sub.2 CH.sub.2                                                                           H    H  OCH.sub.3                                                                            1,1-dimethoxyethyl                                                                           CH                      H         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             1,1-dimethoxyethyl                                                                           CH                      CH.sub.3  OSO.sub.2 CH.sub.3                                                                          H    H  CH.sub.3                                                                             methoxy(methylthio)methyl                                                                    CH                      H         CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            methoxy(methylthio)methyl                                                                    CH                      CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                            bis(methylthio)methyl                                                                        CH                      H         SO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                             bis(methylthio)methyl                                                                        CH                      CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                             1,3-dioxolan-2-yl                                                                            CH                      H         SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            1,3,dioxolan-2-yl                                                                            N                       CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             2-methyl-1,3-  CH                                                             dioxolan-2-yl                          H         NO.sub.2      H    H  OCH.sub.3                                                                            2-methyl-1,3-  CH                                                             dioxolan-2-yl                          CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            1,3-dioxan-2-yl                                                                              CH                      H         OSO.sub.2 CH.sub.3                                                                          H    H  CH.sub.3                                                                             1,3-dioxan-2-yl                                                                              CH                      CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             1,3-oxathiolan-2-yl                                                                          CH                      H         SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            1,3-oxathiolan-2-yl                                                                          CH                      CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            1,3-dithiolan-2-yl                                                                           CH                      H         OSO.sub.2 CH.sub.3                                                                          H    H  CH.sub.3                                                                             1,3-dithiolan-2-yl                                                                           CH                      CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             4-methyl-1,3-  CH                                                             dioxolan-2-yl                          H         OSO.sub.2 CH.sub.3                                                                          H    H  OCH.sub.3                                                                            4-methyl-1,3-  CH                                                             dioxolan-2-yl                          CH.sub.3  NO.sub.2      H    H  OCH.sub.3                                                                            2,4-dimethyl-1,3-                                                                            CH                                                             dioxolan-2-yl                          H         CO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                             2,4-dimethyl-1,3-                                                                            CH                                                             dioxolan-2-yl                          CH.sub.3  OSO.sub.2 CH.sub.3                                                                          H    H  CH.sub.3                                                                             5-methyl-1,3-  CH                                                             oxathiolan-2-yl                        H         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                            5-methyl-1,3-  CH                                                             oxathiolan-2-yl                        CH.sub.3  SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            4-methyl-1,3-  CH                                                             oxathiolan-2-yl                        H         NO.sub.2      H    H  CH.sub.3                                                                             4-methyl-1,3-  CH                                                             oxathiolan-2-yl                        CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                             4-methyl-1,3-  CH                                                             dithiolan-2-yl                         H         SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            4-methyl-1,3-  CH                                                             dithiolan-2-yl                         __________________________________________________________________________

                                      TABLE 7                                     __________________________________________________________________________    General Structure 7                                                           R.sub.1   R.sub.4                                                                              R  X    Y      Z  m.p. (°C.)                          __________________________________________________________________________    H         Cl     H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            H         Cl     H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            H         Cl     H  Cl   OCH.sub.3                                                                            CH                                            H         Cl     H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             H         Cl     H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             H         Cl     CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            CH.sub.3  Cl     H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            CH.sub.3  Cl     H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CH.sub.3  Cl     H  Cl   OCH.sub.3                                                                            CH                                            CH.sub.3  Cl     H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CH.sub.3  Cl     H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             CH.sub.2 CH.sub.3                                                                       Cl     H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            (CH.sub.2).sub.2 CH.sub.3                                                               Cl     H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CF.sub.2 H                                                                              Cl     H  Cl   OCH.sub.3                                                                            CH                                            CH.sub.2 CF.sub.3                                                                       Cl     H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                             Cl     H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             CH.sub.2 CH.sub.2 OH                                                                    Cl     H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            CH.sub.2 CH.sub.2 OSi(CH.sub. 3).sub.3                                                  Cl     H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            OH        Cl     H  Cl   OCH.sub.3                                                                            CH                                            OSi(CH.sub.3).sub.3                                                                     Cl     H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             OCH.sub.3 Cl     H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             OCH.sub.2 CH.sub.3                                                                      Cl     H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.3                                                                       Cl     H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            C.sub.6 H.sub.5                                                                         Cl     H  Cl   OCH.sub.3                                                                            CH                                            CH.sub.2 C.sub.6 H.sub.5                                                                Cl     H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CH.sub.3  H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             CH.sub.3  CH.sub.3                                                                             H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            CH.sub.3  OCH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CH.sub.3  F      H  Cl   OCH.sub.3                                                                            CH                                            CH.sub.3  Br     H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                           H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             CH.sub.3  OSO.sub.2 CH.sub.3                                                                   H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            CH.sub.3  SO.sub.2 CH.sub.3                                                                    H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CH.sub.3  Cl     H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                    N                                             CH.sub.3  Cl     H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            CH.sub.3  Cl     H  OCH.sub.3                                                                          OCF.sub.2 H                                                                          CH                                            CH.sub.3  Cl     H  OCF.sub.2 H                                                                        OCF.sub.2 H                                                                          CH                                            H         Cl     H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            H         Cl     H  OCH.sub.3                                                                          CH.sub.2 S(O)CH.sub.3                                                                CH                                            __________________________________________________________________________

                                      TABLE 8                                     __________________________________________________________________________    General Structure 8                                                           R.sub.1   R.sub.5     R  X    Y    Z  m.p. (°C.)                       __________________________________________________________________________    H         SO.sub.2 N(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                         H         SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                         H         SO.sub.2 N(CH.sub.3).sub.2                                                                H  Cl   OCH.sub.3                                                                          CH                                         H         SO.sub.2 N(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                          H         SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                          H         SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                         CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                         CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                         CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  Cl   OCH.sub.3                                                                          CH                                         CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                          CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                          CH.sub.2 CH.sub.3                                                                       SO.sub.2 N(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                         (CH.sub.2).sub. 2 CH.sub.3                                                              SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                         CF.sub.2 H                                                                              SO.sub.2 N(CH.sub.3).sub.2                                                                H  Cl   OCH.sub.3                                                                          CH                                         CH.sub.2 CF.sub.3                                                                       SO.sub.2 N(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                          CH.sub.2 CH.sub.2 OCH.sub.3                                                             SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                          CH.sub.2 CH.sub.2 OH                                                                    SO.sub.2 N(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                         CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                         OH        SO.sub.2 N(CH.sub.3).sub.2                                                                H  Cl   OCH.sub.3                                                                          CH                                         OSi(CH.sub.3).sub.3                                                                     SO.sub.2 N(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                          OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                          OCH.sub.2 CH.sub.3                                                                      SO.sub.2 N(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                         SO.sub.2 CH.sub.3                                                                       SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                         C.sub.6 H.sub.5                                                                         SO.sub.2 N(CH.sub.3).sub.2                                                                H  Cl   OCH.sub.3                                                                          CH                                         CH.sub.2 C.sub.6 H.sub.5                                                                SO.sub.2 N(CH.sub.3).sub. 2                                                               H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                          CH.sub.3  CH.sub.3    H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                          CH.sub.3  CH.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                         CH.sub.3  OCH.sub.3   H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                         CH.sub.3  OCH.sub.2 CH.sub.3                                                                        H  Cl   OCH.sub.3                                                                          CH                                         CH.sub.3  F           H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                          CH.sub.3  Cl          H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                          CH.sub.3  Br          H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                         CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                         CH.sub.3  SO.sub.2 N(CH.sub.3)(CH.sub.2).sub.2 CH.sub.3                                             H  Cl   OCH.sub.3                                                                          CH                                         CH.sub.3  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                          CH.sub.3  SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                          CH.sub.3  SO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                         CH.sub.3  SO.sub.2 CH.sub.2 CH.sub.3                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                         CH.sub.3  SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                        H  Cl   OCH.sub.3                                                                          CH                                         CH.sub.3  SO.sub.2 CH.sub.2 CH═CH.sub.2                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                          H         SO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                          H         OCH.sub.2 CH.sub.3                                                                        H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                         H         Cl          H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                         H         Br          H  Cl   OCH.sub.3                                                                          CH                                         CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCF.sub.2 H                                                                        CH                                         CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCF.sub.2 H                                                                        OCF.sub.2 H                                                                        CH                                         CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                         CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  N                                          H         SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          NH.sub.2                                                                           CH                                         __________________________________________________________________________

                                      TABLE 9                                     __________________________________________________________________________    General Structure 9                                                           L  R.sub.1   R.sub.6     R  X    Y    Z  m.p. (°C.)                    __________________________________________________________________________    L-4                                                                              H         CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-4                                                                              H         CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-4                                                                              H         CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-4                                                                              H         CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-4                                                                              H         CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-4                                                                              H         CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.2 CH.sub.3                                                                       CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-4                                                                              (CH.sub.2).sub.2 CH.sub.3                                                               CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-4                                                                              CF.sub.2 H                                                                              CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.2 CF.sub.3                                                                       CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-4                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                             CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-4                                                                              CH.sub.2 CH.sub.2 OH                                                                    CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-4                                                                              OH        CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-4                                                                              OSi(CH.sub.3).sub.3                                                                     CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-4                                                                              OCH.sub.3 CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-4                                                                              OCH.sub.2 CH.sub.3                                                                      CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-4                                                                              SO.sub.2 CH.sub.3                                                                       CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-4                                                                              C.sub.6 H.sub.5                                                                         CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  F           H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-4                                                                              CH.sub.3  Cl          H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-4                                                                              CH.sub.3  Br          H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  NO.sub.2    H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-4                                                                              CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-4                                                                              CH.sub.3  SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  SO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  N                                       L-4                                                                              CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                                                               H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                        H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      H  Cl   OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.2 CH═CH.sub.2                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-4                                                                              CH.sub.3  SO.sub.2 N(CH.sub.3)(CH.sub.2 ).sub.2 CH.sub.3                                            H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  SO.sub.2 CH.sub.2 CH.sub.3                                                                H  Cl   OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                        H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-4                                                                              CH.sub.3  SO.sub.2 CH.sub.2 CH═CH.sub.2                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                      L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCF.sub.2 H                                                                        CH                                      L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCF.sub.2 H                                                                        OCF.sub.2 H                                                                        CH                                      L-5                                                                              H         CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-5                                                                              H         CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-5                                                                              H         CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-5                                                                              H         CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-5                                                                              H         CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-5                                                                              H         CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.2 CH.sub.3                                                                       CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-5                                                                              (CH.sub.2).sub.2 CH.sub.3                                                               CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-5                                                                              CF.sub.2 H                                                                              CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.2 CF.sub.3                                                                       CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-5                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                             CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-5                                                                              CH.sub.2 CH.sub.2 OH                                                                    CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-5                                                                              OH        CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-5                                                                              OSi(CH.sub.3).sub.3                                                                     CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-5                                                                              OCH.sub.3 CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub. 3                                                                         N                                       L-5                                                                              OCH.sub.3 CH.sub.3                                                                      CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-5                                                                              SO.sub.2 CH.sub.3                                                                       CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-5                                                                              C.sub.6 H.sub.5                                                                         CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  F           H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-5                                                                              CH.sub.3  Cl          H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-5                                                                              CH.sub.3  Br          H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  NO.sub.2    H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-5                                                                              CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-5                                                                              CH.sub.3  SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  SO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  N                                       L-5                                                                              CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                                                               H  CH.sub. 3                                                                          OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                        H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      H  Cl   OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.2 CH═CH.sub.2                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-5                                                                              CH.sub.3  SO.sub.2 N(CH.sub.3)(CH.sub.2).sub.2 CH.sub.3                                             H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  SO.sub.2 CH.sub.2 CH.sub.3                                                                H  Cl   OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                        H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-5                                                                              CH.sub.3  SO.sub.2 CH.sub.2 CH═CH.sub.2                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                      L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCF.sub.2 H                                                                        CH                                      L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCF.sub.2 H                                                                        OCF.sub.2 H                                                                        CH                                      L-6                                                                              H         CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-6                                                                              H         CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-6                                                                              H         CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-6                                                                              H         CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-6                                                                              H         CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-6                                                                              H         CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.2 CH.sub.3                                                                       CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-6                                                                              (CH.sub.2).sub.2 CH.sub.3                                                               CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-6                                                                              CF.sub.2 H                                                                              CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.2 CF.sub.3                                                                       CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-6                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                             CO.sub.2 CH.sub. 3                                                                        H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-6                                                                              CH.sub.2 CH.sub.2 OH                                                                    CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-6                                                                              OH        CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-6                                                                              OSi(CH.sub.3).sub.3                                                                     CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-6                                                                              OCH.sub.3 CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-6                                                                              OCH.sub.2 CH.sub.3                                                                      CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-6                                                                              SO.sub.2 CH.sub.3                                                                       CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-6                                                                              C.sub.6 H.sub.5                                                                         CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  F           H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-6                                                                              CH.sub.3  Cl          H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-6                                                                              CH.sub.3  Br          H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  NO.sub.2    H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-6                                                                              CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-6                                                                              CH.sub.3  SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  SO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  N                                       L-6                                                                              CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                                                               H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                        H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      H  Cl   OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.2 CH═CH.sub.2                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-6                                                                              CH.sub.3  SO.sub.2 N(CH.sub.3)(CH.sub.2).sub.2 CH.sub.3                                             H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  SO.sub.2 CH.sub.2 CH.sub.3                                                                H  Cl   OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub. 3 SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                        H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-6                                                                              CH.sub.3  SO.sub.2 CH.sub.2 CH═CH.sub.2                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                      L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCF.sub.2 H                                                                        CH                                      L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCF.sub.2 H                                                                        OCF.sub.2 H                                                                        CH                                      __________________________________________________________________________

                                      TABLE 10                                    __________________________________________________________________________    General Structure 10                                                          R.sub.9                                                                          R.sub.1   R.sub.7                                                                             R.sub.8                                                                          R.sub.3                                                                             Q.sub.1                                                                         m R  X    Y    Z  m.p. (°C.)             __________________________________________________________________________    H  H         H     H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  H         H     H  H     O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  H         H     H  H     O 0 H  Cl   OCH.sub.3                                                                          CH                               H  H         H     H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  H         H     H  H     O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  H         H     H  H     O 0 CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  H     O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  H     O 0 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  H     O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.2 CH.sub.3                                                                       H     H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  (CH.sub.2).sub.2 CH.sub.3                                                               H     H  H     O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CF.sub.2 H                                                                              H     H  H     O 0 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.2 CF.sub.3                                                                       H     H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CH.sub.2 CH.sub.2 OCH.sub.3                                                             H     H  H     O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.2 CH.sub.2 OH                                                                    H     H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   H     H  H     O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  OH        H     H  H     O 0 H  Cl   OCH.sub.3                                                                          CH                               H  OSi(CH.sub.3).sub.3                                                                     H     H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  OCH.sub.3 H     H  H     O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  OCH.sub.2 CH.sub.3                                                                      H     H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  SO.sub.2 CH.sub.3                                                                       H     H  H     O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  C.sub.6 H.sub.5                                                                         H     H  H     O 0 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.2 C.sub.6 H.sub.5                                                                H     H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                CH.sub.3                                                                         H         H     H  H     O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                CH.sub.3                                                                         CH.sub.3  H     H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  CH.sub.3                                                                            H  H     O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.3  CH.sub.3                                                                            CH.sub.3                                                                         H     O 0 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.3  CH.sub.2 CH.sub.3                                                                   H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                           H  H     O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.3  (CH.sub.2).sub.3 CH.sub.3                                                           H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  5-F   O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  6-Cl  O 0 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  5-Br  O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  5-CF.sub.3                                                                          O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  6-CH.sub.3                                                                          O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  5-OCH.sub.3                                                                         O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  6-OCF.sub.2 H                                                                       O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  5-OC.sub.2 H.sub.5                                                                  O 0 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  H     O 0 H  OCF.sub.2 H                                                                        OCF.sub.2 H                                                                        CH                               H  H         H     H  H     O 0 H  OCH.sub.3                                                                          OCF.sub.2 H                                                                        CH                               H  CH.sub.3  H     H  H     O 0 H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  N                                H  CH.sub.3  H     H  H     O 0 H  CH.sub.3                                                                           CH.sub.3                                                                           CH                               H  H         H     H  H     O 1 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  H     O 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.2 CH.sub.3                                                                       H     H  H     O 1 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.2 CF.sub.3                                                                       H     H  H     O 1 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CF.sub.2 H                                                                              H     H  H     O 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.3  CH.sub.3                                                                            CH.sub.3                                                                         H     O 1 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  6-F   O 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  5-Cl  O 1 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  6-Br  O 1 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  6-CF.sub.3                                                                          O 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  5-CH.sub.3                                                                          O 1 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  6-OCH.sub.3                                                                         O 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  5-OCF.sub.2 H                                                                       O 1 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  6-OC.sub.2 H.sub.5                                                                  O 1 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  H         (CH.sub.2).sub.3 CH.sub.3                                                           H  H     O 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  H     O 1 CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  H     O 1 H  CH.sub.3                                                                           CH.sub.3                                                                           CH                               H  CH.sub.3  H     H  H     O 1 H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  N                                H  CH.sub.3  H     H  H     O 1 H  OCH.sub.3                                                                          N(CH.sub.3 ).sub.2                                                                 CH                               H  (CH.sub.2).sub.2 CF.sub.3                                                               H     H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  H         H     H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  H         H     H  H     S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  H         H     H  H     S 0 H  Cl   OCH.sub.3                                                                          CH                               H  H         H     H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  H         H     H  H     S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  H         H     H  H     S 0 CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  H     S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  H     S 0 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  H     S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.2 CH.sub.3                                                                       H     H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  (CH.sub.2).sub.2 CH.sub.3                                                               H     H  H     S 0 H  OCH.sub.3                                                                          OCH.sub. 3                                                                         CH                               H  CF.sub.2 H                                                                              H     H  H     S 0 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.2 CF.sub.3                                                                       H     H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CH.sub.2 CH.sub.2 OCH.sub.3                                                             H     H  H     S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.2 CH.sub.2 OH                                                                    H     H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   H     H  H     S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  OH        H     H  H     S 0 H  Cl   OCH.sub.3                                                                          CH                               H  OSi(CH.sub.3).sub.3                                                                     H     H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  OCH.sub.3 H     H  H     S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  OCH.sub.2 CH.sub.3                                                                      H     H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  SO.sub.2 CH.sub.3                                                                       H     H  H     S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  C.sub.6 H.sub.5                                                                         H     H  H     S 0 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.2 C.sub.6 H.sub.5                                                                H     H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                CH.sub.3                                                                         H         H     H  H     S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                CH.sub.3                                                                         CH.sub.3  H     H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  CH.sub.3                                                                            H  H     S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.3  CH.sub.3                                                                            CH.sub.3                                                                         H     S 0 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.3  CH.sub.2 CH.sub.3                                                                   H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                           H  H     S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.3  (CH.sub.2).sub.3 CH.sub.3                                                           H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  5-F   S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  6-Cl  S 0 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  5-Br  S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  5-CF.sub.3                                                                          S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  6-CH.sub.3                                                                          S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  5-OCH.sub.3                                                                         S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  6-OCF.sub. 2 H                                                                      S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  5-OC.sub.2 H.sub.5                                                                  S 0 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  H     S 0 H  OCF.sub.2 H                                                                        OCF.sub.2 H                                                                        CH                               H  H         H     H  H     S 0 H  OCH.sub.3                                                                          OCF.sub.2 H                                                                        CH                               H  CH.sub.3  H     H  H     S 0 H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  N                                H  CH.sub.3  H     H  H     S 0 H  CH.sub.3                                                                           CH.sub.3                                                                           CH                               H  H         H     H  H     S 1 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  H     S 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.2 CH.sub.3                                                                       H     H  H     S 1 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.2 CF.sub.3                                                                       H     H  H     S 1 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CF.sub.2 H                                                                              H     H  H     S 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.3  CH.sub.3                                                                            CH.sub.3                                                                         H     S 1 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  6-F   S 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  5-Cl  S 1 H  Cl   OCH.sub. 3                                                                         CH                               H  CH.sub.3  H     H  6-Br  S 1 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  6-CF.sub.3                                                                          S 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  5-CH.sub.3                                                                          S 1 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  6-OCH.sub.3                                                                         S 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  5-OCF.sub.2 H                                                                       S 1 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  6-OC.sub.2 H.sub.5                                                                  S 1 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  H         (CH.sub.2).sub.3 CH.sub.3                                                           H  H     S 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  H     S 1 CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  H     S 1 H  CH.sub.3                                                                           CH.sub.3                                                                           CH                               H  CH.sub.3  H     H  H     S 1 H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  N                                H  CH.sub.3  H     H  H     S 1 H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  CH                               H  (CH.sub.2).sub.2 CF.sub.3                                                               H     H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  H         CH.sub.3                                                                            H  5-OCF.sub.3                                                                         O 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               CH.sub.3                                                                         CH.sub.3  H     H  5-SCH.sub.3                                                                         O 0 H  OCH.sub.3                                                                          CH.sub.3                                                                           N                                H  H         H     H  6-CH.sub.2 CH.sub.3                                                                 S 1 H  CH.sub.3                                                                           CH.sub.3                                                                           CH                               __________________________________________________________________________

                                      TABLE 11                                    __________________________________________________________________________    General Structure 11                                                          R.sub.1   R.sub.10                                                                            R.sub.11                                                                         R.sub.3                                                                              Q.sub.2                                                                         R  X    Y    Z  m.p. (°C.)                 __________________________________________________________________________    H         H     H  H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                   H         H     H  H      O H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                   H         H     H  H      O H  Cl   OCH.sub.3                                                                          CH                                   H         H     H  H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                    H         H     H  H      O H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                    H         H     H  H      O CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                          N                                    CH.sub.3  H     H  H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                   CH.sub.3  H     H  H      O H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                   CH.sub.3  H     H  H      O H  Cl   OCH.sub.3                                                                          CH                                   CH.sub.3  H     H  H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                    CH.sub.3  H     H  H      O H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                    CH.sub.2 CH.sub.3                                                                       H     H  H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                   (CH.sub.2).sub.2 CH.sub.3                                                               H     H  H      O H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                   CF.sub.2 H                                                                              H     H  H      O H  Cl   OCH.sub.3                                                                          CH                                   CH.sub.2 CF.sub.3                                                                       H     H  H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                    CH.sub.2 CH.sub.2 OCH.sub.3                                                             H     H  H      O H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                    CH.sub.2 CH.sub.2 OH                                                                    H     H  H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                   CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   H     H  H      O H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                   OH        H     H  H      O H  Cl   OCH.sub.3                                                                          CH                                   OSi(CH.sub.3).sub.3                                                                     H     H  H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                    OCH.sub.3 H     H  H      O H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                    OCH.sub.2 CH.sub.3                                                                      H     H  H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                   SO.sub.2 CH.sub.3                                                                       H     H  H      O H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                   C.sub.6 H.sub.5                                                                         H     H  H      O H  Cl   OCH.sub.3                                                                          CH                                   CH.sub.2 C.sub.6 H.sub.5                                                                H     H  H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                    CH.sub.3  CH.sub.3                                                                            H  H      O H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                    CH.sub.3  CH.sub.3                                                                            CH.sub.3                                                                         H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                   CH.sub.3  CH.sub.2 CH.sub. 3                                                                  H  H      O H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                   CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                           H  H      O H  Cl   OCH.sub.3                                                                          CH                                   CH.sub.3  (CH.sub.2).sub.3 CH.sub.3                                                           H  H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                    CH.sub.3  H     H  5-F    O H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                    CH.sub.3  H     H  6-Cl   O H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                   CH.sub.3  H     H  5-Br   O H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                   CH.sub.3  H     H  6-CF.sub.3                                                                           O H  Cl   OCH.sub.3                                                                          CH                                   CH.sub.3  H     H  5-CH.sub.3                                                                           O H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                    CH.sub.3  H     H  6-OCH.sub.3                                                                          O H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                    CH.sub.3  H     H  5-OCF.sub.2 H                                                                        O H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                   CH.sub.3  H     H  6-OC.sub.2 H.sub.5                                                                   O H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                   H         H     H  H      S H  Cl   OCH.sub.3                                                                          CH                                   CH.sub.3  H     H  H      S H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                    CH.sub.2 CH.sub.3                                                                       H     H  H      S H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                    CH.sub.2 CF.sub.3                                                                       H     H  H      S H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                   CF.sub.2 H                                                                              H     H  H      S H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                   CH.sub.3  CH.sub.3                                                                            CH.sub.3                                                                         H      S H  Cl   OCH.sub.3                                                                          CH                                   CH.sub.3  H     H  5-Cl   S H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                    CH.sub.3  H     H  5-CF.sub.3                                                                           S H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                    CH.sub.3  H     H  6-CH.sub.3                                                                           S H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                   CH.sub.3  H     H  H      S H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                   CH.sub.3  H     H  H      O H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  N                                    CH.sub.3  H     H  H      O H  OCH.sub.3                                                                          OCF.sub.2 H                                                                        CH                                   CH.sub.3  H     H  H      O H  OCF.sub.2 H                                                                        OCF.sub.2 H                                                                        CH                                   (CH.sub.2).sub.2 CF.sub.3                                                               H     H  H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                    H         H     H  5-OCF.sub.3                                                                          O H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                   CH.sub.3  H     H  5-CH.sub.2 CH.sub.3                                                                  S H  Cl   OCH.sub.3                                                                          CH                                   CH.sub.3  H     H  6-CH.sub.2 SCH.sub.3                                                                 O H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                    __________________________________________________________________________

                                      TABLE 12                                    __________________________________________________________________________    General Structure 12                                                          L  R.sub.1   R.sub.12 R.sub.3                                                                            R.sub.9                                                                          m R  X    Y    Z  m.p. (°C.)             __________________________________________________________________________    L-9                                                                              H         CH.sub.3 H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-9                                                                              H         CH.sub.3 H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              H         CH.sub.3 H    H  0 H  Cl   OCH.sub.3                                                                          CH                               L-9                                                                              H         CH.sub.3 H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                L-9                                                                              H         CH.sub.3 H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                L-9                                                                              H         CH.sub.3 H    H  0 CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.3  CH.sub.3 H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.3 H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.3 H    H  0 H  Cl   OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.3 H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.3  CH.sub.3 H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub. 3                                                                              H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-9                                                                              (CH.sub.2).sub.2 CH.sub.3                                                               CH.sub.3 H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              CF.sub.2 H                                                                              CH.sub.3 H    H  0 H  Cl   OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.2 CF.sub.3                                                                       CH.sub.3 H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.2 CH.sub.2 CF.sub.3                                                              CH.sub.3 H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                             CH.sub.3 H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.2 CH.sub.2 OH                                                                    CH.sub.3 H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   CH.sub.3 H    H  0 H  Cl   OCH.sub.3                                                                          CH                               L-9                                                                              OH        CH.sub.3 H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                L-9                                                                              OSi(CH.sub.3).sub.3                                                                     CH.sub.3 H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                L-9                                                                              OCH.sub.3 CH.sub.3 H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-9                                                                              OCH.sub.2 CH.sub.3                                                                      CH.sub.3 H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              SO.sub.2 CH.sub.3                                                                       CH.sub.3 H    H  0 H  Cl   OCH.sub.3                                                                          CH                               L-9                                                                              C.sub.6 H.sub.5                                                                         CH.sub.3 H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                CH.sub.3 H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                L-9                                                                              H         H        H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  H        H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.2 CH.sub.3                                                                      H    H  0 H  Cl   OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                              H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.3  (CH.sub.2).sub.3 CH.sub.3                                                              H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.3  (CH.sub.2).sub.4 CH.sub.3                                                              H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  (CH.sub.2).sub.5 CH.sub.3                                                              H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              H         CH.sub.3 H    CH.sub.3                                                                         0 H  Cl   OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.3 H    CH.sub.3                                                                         0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.3  CH.sub.3 6-F  H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.3  CH.sub.3 5-Cl H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.3 6-Br H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.3 5-CF.sub.3                                                                         H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.3 6-CH.sub.3                                                                         H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.3  CH.sub.3 5-OCH.sub.3                                                                        H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.3  CH.sub.3 6-OCF.sub.2 H                                                                      H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.3 5-OC.sub.2 H.sub.5                                                                 H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              H         CH.sub.3 H    H  1 H  Cl   OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.3 H    H  1 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.3  CH.sub.3 H    H  1 H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  CH                               L-9                                                                              CH.sub.3  CH.sub.3 H    H  0 H  CH.sub.3                                                                           CH.sub.3                                                                           CH                               L-9                                                                              CH.sub.3  CH.sub.3 H    H  0 H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  N                                L-9                                                                              CH.sub.3  CH.sub.3 H    H  0 H  OCF.sub.2 H                                                                        OCF.sub.2 H                                                                        CH                               L-9                                                                              CH.sub.3  CH.sub.2 CH.sub.2 Cl                                                                   H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.2 CH.sub.2 Cl                                                                   H    H  0 H  OCH.sub.3                                                                          CH.sub.3                                                                           N                                L-9                                                                              CH.sub.3  CH.sub.2 CH.sub.2 F                                                                    H    H  0 H  OCH.sub.3                                                                          CH.sub.3                                                                           N                                L-9                                                                              CH.sub.3  CH.sub.2 CH.sub.2 F                                                                    H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.2 CF.sub.3                                                                      H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.2 CF.sub.3                                                                      H    H  0 H  OCH.sub.3                                                                          CH.sub.3                                                                           N                                L-9                                                                              CH.sub.3  CH.sub.2 CH.sub.2 Br                                                                   H    H  0 H  OCH.sub.3                                                                          CH.sub.3                                                                           N                                L-9                                                                              CH.sub.3  CH.sub.2 CH.sub.2 OCH.sub.3                                                            H    H  0 H  OCH.sub.3                                                                          CH.sub.3                                                                           N                                L-9                                                                              CH.sub.3  CH.sub.2 CH.sub.2 OCH.sub.3                                                            H    H  0 H  OCH.sub.3                                                                          CH.sub.3                                                                           CH                               L-9                                                                              CH.sub.3  CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                     H    H  0 H  OCH.sub.3                                                                          CH.sub.3                                                                           CH                               L-9                                                                              CH.sub.3  CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                     H    H  0 H  OCH.sub.3                                                                          CH.sub.3                                                                           N                                L-9                                                                              CH.sub.3  (CH.sub.2).sub.3 CH.sub.2 OCH.sub.3                                                    H    H  0 H  OCH.sub.3                                                                          CH.sub.3                                                                           N                                L-9                                                                              CH.sub.3  (CH.sub.2).sub.3 CH.sub.2 Cl                                                           H    H  0 H  OCH.sub.3                                                                          CH.sub.3                                                                           CH                               L-9                                                                              H         CO(CH.sub.2).sub.2 CH.sub.3                                                            H    H  0 H  CH.sub.3                                                                           CH.sub.3                                                                           CH                               L-9                                                                              CH.sub.3  CO.sub.2 C.sub.2 H.sub.5                                                               H    H  0 H  OCH.sub.3                                                                          CH.sub.3                                                                           N                                L-9                                                                              CH.sub.3  CH.sub.2 CF.sub.3                                                                      H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  (CH.sub.2).sub.3 CH.sub.2 Br                                                           H    H  0 H  CH.sub.3                                                                           CH.sub.3                                                                           CH                               L-9                                                                              CH.sub.3  CH.sub.2 CH.sub.2 OCH.sub.3                                                            H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                __________________________________________________________________________

                                      TABLE 12A                                   __________________________________________________________________________    General Structure 12                                                          L  R.sub.1   Q.sub.5                                                                           R.sub.3                                                                            R.sub.9                                                                          m R  X    Y     Z  m.p. (°C.)                 __________________________________________________________________________    L-10                                                                             H         O   H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                   L-10                                                                             H         O   H    H  0 H  Cl   OCH.sub.3                                                                           CH                                   L-10                                                                             H         O   H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                    L-10                                                                             H         O   H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                    L-10                                                                             H         O   H    H  0 CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.3  O   H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.3  O   H    H  0 H  Cl   OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.3  NCH.sub.3                                                                         H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                    L-10                                                                             CH.sub.3  NCH.sub.3                                                                         H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                    L-10                                                                             CH.sub.3  NCH.sub.3                                                                         H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.2 CH.sub.3                                                                       NCH.sub.3                                                                         H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                   L-10                                                                             (CH.sub.2).sub.2 CH.sub.3                                                               NH  H    H  0 H  Cl   OCH.sub.3                                                                           CH                                   L-10                                                                             CF.sub.2 H                                                                              NH  H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                    L-10                                                                             CH.sub.2 CF.sub.3                                                                       NH  H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                    L-10                                                                             CH.sub.2 CH.sub.2 CF.sub.3                                                              NH  H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                             NH  H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.2 CH.sub.2 OH                                                                    O   H    H  0 H  Cl   OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   O   H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                    L-10                                                                             OH        O   H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                    L-10                                                                             OSi(CH.sub.3).sub.3                                                                     O   H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                   L-10                                                                             OCH.sub.3 O   H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                   L-10                                                                             OCH.sub.2 CH.sub.3                                                                      O   H    H  0 H  Cl   OCH.sub.3                                                                           CH                                   L-10                                                                             SO.sub.2 CH.sub.3                                                                       O   H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                    L-10                                                                             C.sub.6 H.sub.5                                                                         O   H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                    L-10                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                O   H    H  0 H  CH.sub. 3                                                                          OCH.sub.3                                                                           CH                                   L-10                                                                             H         O   H    CH.sub.3                                                                         0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.3  O   H    CH.sub.3                                                                         0 H  Cl   OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.3  O   5-F  H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                    L-10                                                                             CH.sub.3  O   6-Cl H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                    L-10                                                                             CH.sub.3  O   5-Br H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.3  O   6-CF.sub.3                                                                         H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.3  O   5-CH.sub.3                                                                         H  0 H  Cl   OCH.sub.3                                                                           CH                                   L-10                                                                             H         O   H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                   L-10                                                                             H         O   SCH.sub.3                                                                          H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                    L-10                                                                             CH.sub.3  O   6-OCH.sub.3                                                                        H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                    L-10                                                                             CH.sub.3  O   5-OCF.sub.2 H                                                                      H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                    L-10                                                                             CH.sub.3  O   6-OCF.sub.2 H                                                                      H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.3  O   H    H  1 H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                   L-10                                                                             H         O   H    H  1 H  Cl   OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.2 CH.sub.3                                                                       O   H    H  1 H  CH.sub. 3                                                                          OCH.sub.3                                                                           N                                    L-10                                                                             CH.sub.2 CF.sub.3                                                                       O   H    H  1 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                    L-10                                                                             CF.sub.2 H                                                                              O   H    H  1 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.3  O   H    H  1 H  OCH.sub.3                                                                          OCF.sub.2 H                                                                         CH                                   L-10                                                                             CH.sub.3  O   H    H  0 H  OCF.sub.2 H                                                                        OCF.sub.2 H                                                                         CH                                   L-10                                                                             CH.sub.3  O   H    H  0 H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                   N                                    L-10                                                                             CH.sub.3  O   H    H  0 H  CH.sub.3                                                                           CH.sub.3                                                                            CH                                   L-10                                                                             CH.sub.3  O   H    H  0 H  OCH.sub.3                                                                          OCH.sub.2 CF.sub.3                                                                  N                                    L-10                                                                             CH.sub.3  O   H    H  0 H  OCH.sub.3                                                                          CH.sub.2 OCH.sub.3                                                                  CH                                   L-10                                                                             CH.sub.3  O   H    H  0 H  CH.sub.3                                                                           CF.sub.3                                                                            CH                                   __________________________________________________________________________

                                      TABLE 12B                                   __________________________________________________________________________    General Structure 12                                                          L  R.sub.1                                                                            R.sub.26                                                                         R.sub.27                                                                         R.sub.3                                                                             R.sub.9                                                                          m R  X   Y    Z  m.p. (°C.)                     __________________________________________________________________________    L-11                                                                             CH.sub.3                                                                           H  Cl 6-F   H  1 H  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                       L-11                                                                             CH.sub.3                                                                           H  Cl 6-Br  H  0 H  OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                       L-11                                                                             CH.sub.3                                                                           H  Cl 5-OC.sub.2 H.sub.5                                                                  H  0 H  CH.sub.3                                                                          OCH.sub.3                                                                          N                                        L-11                                                                             H    H  Cl OCF.sub.3                                                                           H  1 H  OCH.sub.3                                                                         OCH.sub.3                                                                          N                                        L-11                                                                             H    H  Cl CH.sub.2 OCH.sub.3                                                                  H  0 H  Cl  OCH.sub.3                                                                          CH                                       L-11                                                                             H    H  H  H     H  0 H  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                       L-11                                                                             H    H  H  H     H  0 CH.sub.3                                                                         OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                       L-11                                                                             CH.sub.3                                                                           H  H  H     H  0 H  Cl  OCH.sub.3                                                                          CH                                       L-11                                                                             CH.sub.2 CH.sub.3                                                                  H  H  H     H  0 H  CH.sub.3                                                                          OCH.sub.3                                                                          N                                        L-11                                                                             CH.sub.2 CF.sub.3                                                                  H  H  H     H  0 H  OCH.sub.3                                                                         OCH.sub.3                                                                          N                                        L-11                                                                             CF.sub.2 H                                                                         H  H  H     H  0 H  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                       L-11                                                                             OCH.sub.3                                                                          H  H  H     H  0 H  OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                       L-11                                                                             SO.sub.2 CH.sub.3                                                                  H  H  H     H  0 H  Cl  OCH.sub.3                                                                          CH                                       L-11                                                                             CH.sub.3                                                                           H  H  H     CH.sub.3                                                                         0 H  CH.sub.3                                                                          OCH.sub.3                                                                          N                                        L-11                                                                             CH.sub.3                                                                           H  H  5-Cl  H  0 H  OCH.sub.3                                                                         OCH.sub.3                                                                          N                                        L-11                                                                             CH.sub.3                                                                           H  H  6-CH.sub.3                                                                          H  0 H  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                       L-11                                                                             CH.sub.3                                                                           H  H  5-CF.sub.3                                                                          H  0 H  OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                       L-11                                                                             CH.sub.3                                                                           H  H  6-OCF.sub.2 H                                                                       H  0 H  Cl  OCH.sub.3                                                                          CH                                       L-11                                                                             CH.sub.3                                                                           H  H  5-OCH.sub.3                                                                         H  0 H  CH.sub.3                                                                          OCH.sub.3                                                                          N                                        L-11                                                                             H    Cl Cl H     H  1 H  OCH.sub.3                                                                         OCH.sub.3                                                                          N                                        L-11                                                                             CH.sub.3                                                                           Cl Cl H     H  1 H  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                       L-11                                                                             CH.sub.3                                                                           Cl Cl H     H  1 H  OCH.sub.3                                                                         N(CH.sub.3).sub.2                                                                  N                                        L-11                                                                             CH.sub.3                                                                           Cl Cl H     H  0 H  OCH.sub.3                                                                         OCF.sub.2 H                                                                        CH                                       L-11                                                                             CH.sub.3                                                                           Cl Cl H     H  0 H  CH.sub.3                                                                          CF.sub. 3                                                                          CH                                       __________________________________________________________________________

                                      TABLE 12C                                   __________________________________________________________________________    General Structure 12                                                                                                 m.p.                                   L  R.sub.1                                                                            R.sub.12  R.sub.3                                                                             R  X   Y    Z  (°C.)                           __________________________________________________________________________    L-12                                                                             H    CH.sub.3  OCH.sub.2 CF.sub.3                                                                  H  Cl  OCH.sub.3                                                                          CH                                        L-12                                                                             H    CH.sub.2 CH.sub.3                                                                       CH.sub.2 OCH.sub.3                                                                  H  OCH.sub.3                                                                         OCH.sub.3                                                                          N                                         L-12                                                                             CH.sub.3                                                                           CH.sub.3  CH.sub.2 SCH.sub.3                                                                  H  CH.sub.3                                                                          CH.sub.3                                                                           CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Br                                                  H     H  OCH.sub.3                                                                         OCH.sub.3                                                                          N                                         L-12                                                                             H    CH.sub.2 OC.sub.2 H.sub.5                                                               H     H  CH.sub.3                                                                          CH.sub.3                                                                           CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.2 CF.sub.3                                                                       H     H  OCH.sub.3                                                                         CH.sub.3                                                                           N                                         L-12                                                                             CH.sub.3                                                                           CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                           H     H  Cl  OCH.sub.3                                                                          CH                                        L-12                                                                             H    COC.sub.2 H.sub.5                                                                       H     H  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                        L-12                                                                             H    CO.sub.2 C.sub.2 H.sub.5                                                                H     H  OCH.sub.3                                                                         OCH.sub.3                                                                          N                                         L-12                                                                             H    CH.sub.3  H     H  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                        L-12                                                                             H    CH.sub.3  H     CH.sub.3                                                                         OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.3  H     H  Cl  OCH.sub.3                                                                          CH                                        L-12                                                                             CH.sub.2 CF.sub.3                                                                  CH.sub.3  H     H  CH.sub.3                                                                          OCH.sub.3                                                                          N                                         L-12                                                                             CH.sub.2 CH.sub.3                                                                  CH.sub.3  H     H  OCH.sub.3                                                                         OCH.sub.3                                                                          N                                         L-12                                                                             CF.sub.2 H                                                                         CH.sub.3  H     H  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                        L-12                                                                             OCH.sub.3                                                                          CH.sub.3  H     H  OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                        L-12                                                                             SO.sub.2 CH.sub.3                                                                  CH.sub.3  H     H  Cl  OCH.sub.3                                                                          CH                                        L-12                                                                             CH.sub.3                                                                           H         H     H  CH.sub.3                                                                          OCH.sub.3                                                                          N                                         L-12                                                                             CH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                       H     H  OCH.sub.3                                                                         OCH.sub.3                                                                          N                                         L-12                                                                             CH.sub.3                                                                           (CH.sub.2).sub.5 CH.sub.3                                                               H     H  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.3  5-F   H  OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.3  6-Cl  H  Cl  OCH.sub.3                                                                          CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.3  5-Br  H  CH.sub.3                                                                          OCH.sub.3                                                                          N                                         L-12                                                                             CH.sub.3                                                                           CH.sub.3  6-CF.sub.3                                                                          H  OCH.sub.3                                                                         OCH.sub.3                                                                          N                                         L-12                                                                             CH.sub.3                                                                           CH.sub.3  5-CH.sub.3                                                                          H  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.3  6-OCH.sub.3                                                                         H  OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.3  5-OCF.sub.2 H                                                                       H  Cl  OCH.sub.3                                                                          CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.3  6-OC.sub.2 H.sub.5                                                                  H  CH.sub.3                                                                          OCH.sub.3                                                                          N                                         L-12                                                                             H    CH.sub.3  H     H  OCH.sub.3                                                                         N(CH.sub.3).sub.2                                                                  N                                         L-12                                                                             CH.sub.3                                                                           CH.sub.3  H     H  CH.sub.3                                                                          CH.sub.3                                                                           CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.3  H     H  OCH.sub.3                                                                         OCF.sub.2 H                                                                        CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.2 CH.sub.2 Cl                                                                    H     H  OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.2 CH.sub.2 Cl                                                                    H     H  OCH.sub.3                                                                         CH.sub.3                                                                           N                                         L-12                                                                             CH.sub.3                                                                           Ch.sub.2 CH.sub.2 F                                                                     H     H  OCH.sub.3                                                                         CH.sub.3                                                                           N                                         L-12                                                                             CH.sub.3                                                                           CH.sub.2 CH.sub.2 F                                                                     H     H  OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.2 CF.sub.3                                                                       H     H  OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.2 CF.sub.3                                                                       H     H  OCH.sub.3                                                                         CH.sub.3                                                                           N                                         L-12                                                                             CH.sub.3                                                                           CH.sub.2 CH.sub.2 Br                                                                    H     H  OCH.sub.3                                                                         CH.sub.3                                                                           N                                         L-12                                                                             CH.sub.3                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                             H     H  OCH.sub.3                                                                         CH.sub.3                                                                           N                                         L-12                                                                             CH.sub.3                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                             H     H  OCH.sub.3                                                                         CH.sub.3                                                                           CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      H     H  OCH.sub.3                                                                         CH.sub.3                                                                           CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      H     H  OCH.sub.3                                                                         CH.sub.3                                                                           N                                         L-12                                                                             CH.sub.3                                                                           (CH.sub.2).sub.3 CH.sub.2 OCH.sub.3                                                     H     H  OCH.sub.3                                                                         CH.sub.3                                                                           N                                         L-12                                                                             CH.sub.3                                                                           (CH.sub.2).sub.3 CH.sub.2 Cl                                                            H     H  OCH.sub.3                                                                         CH.sub.3                                                                           CH                                        __________________________________________________________________________

                                      TABLE 13                                    __________________________________________________________________________    General Structure 13                                                                                                        m.p.                            L  R.sub.1   R.sub.13                                                                            R.sub.3                                                                              R.sub.14                                                                         R  X   Y      Z  (°C.)                    __________________________________________________________________________    L-13                                                                             H         H     H      -- H  CH.sub.3                                                                          OCH.sub.3                                                                            CH                                 L-13                                                                             CH.sub.3  H     H      -- H  OCH.sub.3                                                                         OCH.sub.3                                                                            CH                                 L-13                                                                             CH.sub.2 CH.sub.3                                                                       H     H      -- H  Cl  OCH.sub.3                                                                            CH                                 L-13                                                                             (CH.sub.2).sub.2 CH.sub.3                                                               H     H      -- H  CH.sub.3                                                                          OCH.sub.3                                                                            N                                  L-13                                                                             CF.sub.2 H                                                                              H     H      -- H  OCH.sub.3                                                                         OCH.sub.3                                                                            N                                  L-13                                                                             CH.sub.2 CF.sub.3                                                                       H     H      -- H  CH.sub.3                                                                          OCH.sub.3                                                                            CH                                 L-13                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                             H     H      -- H  OCH.sub.3                                                                         OCH.sub.3                                                                            CH                                 L-13                                                                             CH.sub.2 CH.sub.2 OH                                                                    H     H      -- H  Cl  OCH.sub.3                                                                            CH                                 L-13                                                                             CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   H     H      -- H  CH.sub.3                                                                          OCH.sub.3                                                                            N                                  L-13                                                                             OH        H     H      -- H  OCH.sub.3                                                                         OCH.sub.3                                                                            N                                  L-13                                                                             OSi(CH.sub.3).sub.3                                                                     H     H      -- H  CH.sub.3                                                                          OCH.sub.3                                                                            CH                                 L-13                                                                             OCH.sub.3 H     H      -- H  OCH.sub.3                                                                         OCH.sub.3                                                                            CH                                 L-13                                                                             OCH.sub.2 CH.sub.3                                                                      H     H      -- H  Cl  OCH.sub.3                                                                            CH                                 L-13                                                                             SO.sub.2 CH.sub.3                                                                       H     H      -- H  CH.sub.3                                                                          OCH.sub.3                                                                            N                                  L-13                                                                             C.sub.6 H.sub.5                                                                         H     H      -- H  OCH.sub.3                                                                         OCH.sub.3                                                                            N                                  L-13                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                H     H      -- H  CH.sub.3                                                                          OCH.sub.3                                                                            CH                                 L-13                                                                             CH.sub.3  H     H      -- CH.sub.3                                                                         OCH.sub.3                                                                         OCH.sub.3                                                                            CH                                 L-13                                                                             CH.sub.3  CH.sub.3                                                                            H      -- H  Cl  OCH.sub.3                                                                            CH                                 L-13                                                                             CH.sub.3  CH.sub.2 CH.sub.3                                                                   H      -- H  CH.sub.3                                                                          OCH.sub.3                                                                            N                                  L-13                                                                             CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                           H      -- H  OCH.sub.3                                                                         OCH.sub.3                                                                            N                                  L-13                                                                             CH.sub.3  H     5-F    -- H  CH.sub.3                                                                          OCH.sub.3                                                                            CH                                 L-13                                                                             CH.sub.3  H     6-Cl   -- H  OCH.sub.3                                                                         OCH.sub.3                                                                            CH                                 L-13                                                                             CH.sub.3  H     5-Br   -- H  Cl  OCH.sub.3                                                                            CH                                 L-13                                                                             CH.sub.3  H     6-CF.sub.3                                                                           -- H  CH.sub.3                                                                          OCH.sub.3                                                                            N                                  L-13                                                                             CH.sub.3  H     5-CH.sub.3                                                                           -- H  OCH.sub.3                                                                         OCH.sub.3                                                                            N                                  L-13                                                                             CH.sub.3  H     6-OCH.sub.3                                                                          -- H  CH.sub.3                                                                          OCH.sub.3                                                                            CH                                 L-13                                                                             CH.sub.3  H     5-OCF.sub.2 H                                                                        -- H  OCH.sub.3                                                                         OCH.sub.3                                                                            CH                                 L-13                                                                             CH.sub.3  H     6-OC.sub.2 H.sub.5                                                                   -- H  Cl  OCH.sub.3                                                                            CH                                 L-13                                                                             CH.sub.3  H     H      -- H  CH.sub.3                                                                          CH.sub.3                                                                             CH                                 L-13                                                                             CH.sub.3  H     H      -- H  CH.sub.3                                                                          CF.sub.3                                                                             CH                                 L-13                                                                             CH.sub.3  H     H      -- H  OCH.sub.3                                                                         N(CH.sub.3).sub.2                                                                    N                                  L-13                                                                             CH.sub.3  H     H      -- H  OCH.sub.3                                                                         OCF.sub.2 H                                                                          CH                                 L-14                                                                             H         H     H      -- H  CH.sub.3                                                                          OCH.sub.3                                                                            CH                                 L-14                                                                             CH.sub.3  H     H      -- H  OCH.sub.3                                                                         OCH.sub.3                                                                            CH                                 L-14                                                                             CH.sub.2 CH.sub.3                                                                       H     H      -- H  Cl  OCH.sub.3                                                                            CH                                 L-14                                                                             (CH.sub.2).sub.2 CH.sub.3                                                               H     H      -- H  CH.sub.3                                                                          OCH.sub.3                                                                            N                                  L-14                                                                             CF.sub.2 H                                                                              H     H      -- H  OCH.sub.3                                                                         OCH.sub.3                                                                            N                                  L-14                                                                             CH.sub.2 CF.sub.3                                                                       H     H      -- H  CH.sub.3                                                                          OCH.sub.3                                                                            CH                                 L-14                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                             H     H      -- H  OCH.sub.3                                                                         OCH.sub.3                                                                            CH                                 L-14                                                                             CH.sub.2 CH.sub.2 OH                                                                    H     H      -- H  Cl  OCH.sub.3                                                                            CH                                 L-14                                                                             CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   H     H      -- H  CH.sub.3                                                                          OCH.sub.3                                                                            N                                  L-14                                                                             OH        H     H      -- H  OCH.sub.3                                                                         OCH.sub.3                                                                            N                                  L-14                                                                             OSi(CH.sub.3).sub.3                                                                     H     H      -- H  CH.sub.3                                                                          OCH.sub.3                                                                            CH                                 L-14                                                                             OCH.sub.3 H     H      -- H  OCH.sub.3                                                                         OCH.sub.3                                                                            CH                                 L-14                                                                             OCH.sub.2 CH.sub.3                                                                      H     H      -- H  Cl  OCH.sub.3                                                                            CH                                 L-14                                                                             SO.sub.2 CH.sub.3                                                                       H     H      -- H  CH.sub.3                                                                          OCH.sub.3                                                                            N                                  L-14                                                                             C.sub.6 H.sub.5                                                                         H     H      -- H  OCH.sub.3                                                                         OCH.sub.3                                                                            N                                  L-14                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                H     H      -- H  CH.sub.3                                                                          OCH.sub.3                                                                            CH                                 L-14                                                                             CH.sub.3  H     H      -- CH.sub.3                                                                         OCH.sub.3                                                                         OCH.sub.3                                                                            CH                                 L-14                                                                             CH.sub.3  CH.sub.3                                                                            H      -- H  Cl  OCH.sub.3                                                                            CH                                 L-14                                                                             CH.sub.3  CH.sub.2 CH.sub.3                                                                   H      -- H  CH.sub.3                                                                          OCH.sub.3                                                                            N                                  L-14                                                                             CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                           H      -- H  OCH.sub.3                                                                         OCH.sub.3                                                                            N                                  L-14                                                                             CH.sub.3  H     5-F    -- H  CH.sub.3                                                                          OCH.sub.3                                                                            CH                                 L-14                                                                             CH.sub.3  H     6-Cl   -- H  OCH.sub.3                                                                         OCH.sub.3                                                                            CH                                 L-14                                                                             CH.sub.3  H     5-Br   -- H  Cl  OCH.sub.3                                                                            CH                                 L-14                                                                             CH.sub.3  H     6-CF.sub.3                                                                           -- H  CH.sub.3                                                                          OCH.sub.3                                                                            N                                  L-14                                                                             CH.sub.3  H     5-CH.sub.3                                                                           -- H  OCH.sub.3                                                                         OCH.sub.3                                                                            N                                  L-14                                                                             CH.sub.3  H     6-OCH.sub.3                                                                          -- H  CH.sub.3                                                                          OCH.sub.3                                                                            CH                                 L-14                                                                             CH.sub.3  H     5-OCF.sub.2 H                                                                        -- H  OCH.sub.3                                                                         OCH.sub.3                                                                            CH                                 L-14                                                                             CH.sub.3  H     6-OC.sub.2 H.sub.5                                                                   -- H  Cl  OCH.sub.3                                                                            CH                                 L-14                                                                             CH.sub.3  H     H      -- H  CH.sub.3                                                                          CH.sub.3                                                                             CH                                 L-14                                                                             CH.sub.3  H     H      -- H  CH.sub.3                                                                          CF.sub.3                                                                             CH                                 L-14                                                                             CH.sub.3  H     H      -- H  OCH.sub.3                                                                         N(CH.sub.3).sub.2                                                                    N                                  L-14                                                                             CH.sub.3  H     H      -- H  OCH.sub.3                                                                         OCF.sub.2 H                                                                          CH                                 L-15                                                                             H         CH.sub.3                                                                            H      H  H  CH.sub.3                                                                          OCH.sub.3                                                                            CH                                 L-15                                                                             CH.sub.3  CH.sub.3                                                                            H      H  H  OCH.sub.3                                                                         OCH.sub.3                                                                            CH                                 L-15                                                                             CH.sub.2 CH.sub.3                                                                       CH.sub.3                                                                            H      H  H  Cl  OCH.sub.3                                                                            CH                                 L-15                                                                             (CH.sub.2).sub.2 CH.sub.3                                                               CH.sub.3                                                                            H      H  H  CH.sub.3                                                                          OCH.sub.3                                                                            N                                  L-15                                                                             CF.sub.2 H                                                                              CH.sub.3                                                                            H      H  H  OCH.sub.3                                                                         OCH.sub.3                                                                            N                                  L-15                                                                             CH.sub.2 CF.sub.3                                                                       CH.sub.3                                                                            H      H  H  CH.sub.3                                                                          OCH.sub.3                                                                            CH                                 L-15                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                             CH.sub.3                                                                            H      H  H  OCH.sub.3                                                                         OCH.sub.3                                                                            CH                                 L-15                                                                             CH.sub.2 CH.sub.2 OH                                                                    CH.sub.3                                                                            H      H  H  Cl  OCH.sub.3                                                                            CH                                 L-15                                                                             CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   CH.sub.3                                                                            H      H  H  CH.sub.3                                                                          OCH.sub.3                                                                            N                                  L-15                                                                             OH        CH.sub.3                                                                            H      H  H  OCH.sub.3                                                                         OCH.sub.3                                                                            N                                  L-15                                                                             OSi(CH.sub.3).sub.3                                                                     CH.sub.3                                                                            H      H  H  CH.sub.3                                                                          OCH.sub.3                                                                            CH                                 L-15                                                                             OCH.sub.3 CH.sub.3                                                                            H      H  H  OCH.sub.3                                                                         OCH.sub.3                                                                            CH                                 L-15                                                                             OCH.sub.2 CH.sub.3                                                                      CH.sub.3                                                                            H      H  H  Cl  OCH.sub.3                                                                            CH                                 L-15                                                                             SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                            H      H  H  CH.sub.3                                                                          OCH.sub.3                                                                            N                                  L-15                                                                             C.sub.6 H.sub.5                                                                         CH.sub.3                                                                            H      H  H  OCH.sub.3                                                                         OCH.sub.3                                                                            N                                  L-15                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                CH.sub.3                                                                            H      H  H  CH.sub.3                                                                          OCH.sub.3                                                                            CH                                 L-15                                                                             H         CH.sub.3                                                                            H      H  CH.sub.3                                                                         OCH.sub.3                                                                         OCH.sub.3                                                                            CH                                 L-15                                                                             CH.sub.3  CH.sub.3                                                                            H      H  CH.sub.3                                                                         CH.sub.3                                                                          OCH.sub.3                                                                            N                                  L-15                                                                             CH.sub.3  CH.sub.3                                                                            H      H  H  OCH.sub.3                                                                         OCH.sub.3                                                                            N                                  L-15                                                                             CH.sub.3  CH.sub.3                                                                            H      CH.sub.3                                                                         H  CH.sub.3                                                                          OCH.sub.3                                                                            CH                                 L-15                                                                             CH.sub.3  CH.sub.2 CH.sub.3                                                                   H      H  H  OCH.sub.3                                                                         OCH.sub.3                                                                            CH                                 L-15                                                                             CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                           H      H  H  Cl  OCH.sub.3                                                                            CH                                 L-15                                                                             CH.sub.3  CH.sub.3                                                                            6-F    H  H  CH.sub.3                                                                          OCH.sub.3                                                                            N                                  L-15                                                                             CH.sub.3  CH.sub.3                                                                            5-Cl   H  H  OCH.sub.3                                                                         OCH.sub.3                                                                            N                                  L-15                                                                             CH.sub.3  CH.sub.3                                                                            6-Br   H  H  CH.sub.3                                                                          OCH.sub.3                                                                            CH                                 L-15                                                                             CH.sub.3  CH.sub.3                                                                            5-CF.sub.3                                                                           H  H  OCH.sub.3                                                                         OCH.sub.3                                                                            CH                                 L-15                                                                             CH.sub.3  CH.sub.3                                                                            6-CH.sub.3                                                                           H  H  Cl  OCH.sub.3                                                                            CH                                 L-15                                                                             CH.sub.3  CH.sub.3                                                                            5-OCH.sub.3                                                                          H  H  CH.sub.3                                                                          OCH.sub.3                                                                            N                                  L-15                                                                             CH.sub.3  CH.sub.3                                                                            6-OCF.sub.2 H                                                                        H  H  OCH.sub.3                                                                         OCH.sub.3                                                                            N                                  L-15                                                                             CH.sub.3  CH.sub.3                                                                            5-OC.sub.2 H.sub.5                                                                   H  H  OCH.sub.3                                                                         OCH.sub.3                                                                            CH                                 L-15                                                                             H         CH.sub.3                                                                            6-Cl   H  H  CH.sub.3                                                                          OCH.sub.3                                                                            CH                                 L-15                                                                             CH.sub.3  CH.sub.3                                                                            H      H  H  CH.sub.3                                                                          CH.sub.3                                                                             CH                                 L-15                                                                             CH.sub.3  CH.sub.3                                                                            H      H  H  OCH.sub.3                                                                         N(CH.sub.3).sub.2                                                                    N                                  L-15                                                                             CH.sub.3  CH.sub.3                                                                            H      H  H  OCF.sub.2 H                                                                       OCF.sub.2 H                                                                          CH                                 L-13                                                                             H         H     5-C.sub.2 H.sub.5                                                                    -- H  CH.sub.3                                                                          CH.sub.3                                                                             CH                                 L-13                                                                             CH.sub.3  CH.sub.3                                                                            6-OCH.sub.2 CF.sub.3                                                                 -- H  OCH.sub.3                                                                         OCH.sub.3                                                                            N                                  L-13                                                                             CH.sub.3  CH.sub.3                                                                            6-SCH.sub.3                                                                          -- H  Cl  OCH.sub.3                                                                            CH                                 L-13                                                                             H         H     5-CH.sub.2 OCH.sub.3                                                                 -- H  OCH.sub.3                                                                         C.tbd.CH                                                                             CH                                 L-13                                                                             H         H     5-CH.sub.2 SCH.sub.3                                                                 -- H  OCH.sub.3                                                                         CH.sub.2 S(O)CH.sub.3                                                                N                                  L-14                                                                             H         H     5-C.sub.2 H.sub.5                                                                    -- H  CH.sub.3                                                                          CH.sub.3                                                                             CH                                 L-14                                                                             CH.sub.3  CH.sub.3                                                                            5-OCH.sub.2 CHF.sub.2                                                                -- H  OCH.sub.3                                                                         OCH.sub.3                                                                            CH                                 L-14                                                                             H         H     6-CH.sub.2 SCH.sub.3                                                                 -- H  CH.sub.3                                                                          OCH.sub.3                                                                            CH                                 L-15                                                                             CH.sub.3  CH.sub.3                                                                            5-SC.sub.2 H.sub.5                                                                   H  H  CH.sub.3                                                                          CH.sub.3                                                                             CH                                 L-15                                                                             H         CH.sub.3                                                                            6-OCH.sub.2 CH.sub.2 F                                                               H  H  OCH.sub.3                                                                         OCH.sub.3                                                                            N                                  L-15                                                                             H         CH.sub.3                                                                            5-CH.sub.2 OCH.sub.3                                                                 H  H  OCH.sub.3                                                                         CH.sub.2 SO.sub.2 CH.sub.3                                                           N                                  __________________________________________________________________________

                                      TABLE 14                                    __________________________________________________________________________    General Structure 14                                                          BP = Bridge Position                                                                                                          m.p.                          BP                                                                              R.sub.1   R.sub.16     R.sub.15                                                                            R  X    Y     Z  (°C.)                  __________________________________________________________________________    5 CH.sub.3  4-SO.sub.2 N(OCH.sub.3)CH.sub.3                                                            CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                               5 CH.sub.3  4-SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                               5 CH.sub.3  4-SO.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                           CH                               5 CH.sub.3  4-SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                       CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                5 CH.sub.3  4-SO.sub.2 CH.sub.2 CH═CH.sub.2                                                        CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                5 CH.sub.3  4-OCF.sub.2 H                                                                              CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                               4 H         3-Cl         CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                               4 CH.sub.3  3-CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                           CH                               4 CH.sub.3  3-CO.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                4 CH.sub.3  3-CO.sub.2 (CH.sub. 2).sub.2 CH.sub.3                                                      CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                4 CH.sub.3  3-CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                       CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                               4 CH.sub.3  3-CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                     CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                               4 CH.sub.3  3-CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                            CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                           CH                               4 CH.sub.3  3-CO.sub.2 CH.sub.2 CH═CH.sub.2                                                        CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                4 CH.sub.3  3-NO.sub.2   CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                4 CH.sub.3  5-Br         CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                               4 CH.sub.3  5-CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                               3 H         4-CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                           CH                               3 CH.sub.3  4-CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                3 CH.sub.3  4-Cl         CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                3 CH.sub.3  4-SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                               3 CH.sub.3  4-NO.sub.2   CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                               3 CH.sub.3  4-F          CH.sub.3                                                                            H  OCF.sub.2 H                                                                        OCF.sub.2 H                                                                         CH                               4 CH.sub.3  3-F          CH.sub.3                                                                            H  CHhd 3                                                                             CF.sub.3                                                                            CH                               5 CH.sub.3  4-Cl         CH.sub.3                                                                            H  CH.sub.3                                                                           CH.sub.3                                                                            CH                               5 CH.sub.3  4-Br         CH.sub.3                                                                            H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                   N                                5 CH.sub.3  4-Cl         CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.2 CF.sub.3                                                                  N                                5 CH.sub.3  4-Cl         CH.sub.3                                                                            H  OCH.sub.3                                                                          OCF.sub.2 H                                                                         CH                               5 H         4-Cl         CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                               5 CH.sub.3  4-Cl         CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                               5 CH.sub.2 CH.sub.3                                                                       4-Cl         CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                           CH                               5 (CH.sub.2).sub.2 CH.sub.3                                                               4-Cl         CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                5 CF.sub.2 H                                                                              4-Cl         CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                5 CH.sub.2 CF.sub.3                                                                       4-Cl         CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                               5 CH.sub.2 CH.sub.2 OCH.sub.3                                                             4-Cl         CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                               5 CH.sub.2 CH.sub.2 OH                                                                    4-Cl         CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                           CH                               5 CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   4-Cl         CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                5 OH        4-Cl         CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                5 OSi(CH.sub.3).sub.3                                                                     4-Cl         CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                               5 OCH.sub.3 4-Cl         CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                               5 OCH.sub.2 CH.sub.3                                                                      4-Cl         CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                           CH                               5 SO.sub.2 CH.sub.3                                                                       4-Cl         CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                5 C.sub.6 H.sub.5                                                                         4-Cl         CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                5 CH.sub.2 C.sub.6 H.sub.5                                                                4-Cl         CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                               5 H         4-Cl         CH.sub.3                                                                            CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                           CH                               5 CH.sub.3  H            CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                           CH                               5 CH.sub.3  4-Cl         H     H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                5 CH.sub.3  4-Cl         CH.sub.2 CH.sub.3                                                                   H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                5 CH.sub.3  4-Cl         (CH.sub.2).sub.2 CH.sub.3                                                           H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                               5 CH.sub.3  4-CH.sub.3   CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                           CH                               5 CH.sub.3  4-CH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                               5 CH.sub.3  4-(CH.sub.2).sub.2 CH.sub.3                                                                CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub. 3                                                                          N                                5 CH.sub.3  4-F          CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                5 CH.sub.3  4-Br         CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                               5 CH.sub.3  4-NO.sub.2   CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                               5 CH.sub.3  4-CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                           CH                               5 CH.sub.3  4-SO.sub.2 N(CH.sub.3).sub.2                                                               CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                5 CH.sub.3  4-SO.sub.2 N(CH.sub.3)(CH.sub.2).sub.2 CH.sub.3                                            CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                __________________________________________________________________________

                                      TABLE 15                                    __________________________________________________________________________    General Structure 15                                                          R.sub.1   R.sub.15                                                                            R  X   Y     Z  m.p. (°C.)                             __________________________________________________________________________    H         CH.sub.3                                                                            H  CH.sub.3                                                                          OCH.sub.3                                                                           CH                                               CH.sub.3  CH.sub.3                                                                            H  OCH.sub.3                                                                         OCH.sub.3                                                                           CH                                               CH.sub.2 CH.sub.3                                                                       CH.sub.3                                                                            H  Cl  OCH.sub.3                                                                           CH                                               (CH.sub.2).sub.2 CH.sub.3                                                               CH.sub.3                                                                            H  CH.sub.3                                                                          OCH.sub.3                                                                           N                                                CF.sub.2 H                                                                              CH.sub.3                                                                            H  OCH.sub.3                                                                         OCH.sub.3                                                                           N                                                CH.sub.2 CF.sub.3                                                                       CH.sub.3                                                                            H  CH.sub.3                                                                          OCH.sub.3                                                                           CH                                               CH.sub.2 CH.sub.2 OCH.sub.3                                                             CH.sub.3                                                                            H  OCH.sub.3                                                                         OCH.sub.3                                                                           CH                                               CH.sub.2 CH.sub.2 OH                                                                    CH.sub.3                                                                            H  CH.sub.3                                                                          OCH.sub.3                                                                           N                                                CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   CH.sub.3                                                                            H  OCH.sub.3                                                                         OCH.sub.3                                                                           N                                                OH        CH.sub.3                                                                            H  CH.sub.3                                                                          OCH.sub.3                                                                           CH                                               OSi(CH.sub.3).sub.3                                                                     CH.sub.3                                                                            H  Cl  OCH.sub.3                                                                           CH                                               OCH.sub.3 CH.sub.3                                                                            H  CH.sub.3                                                                          OCH.sub.3                                                                           N                                                OCH.sub.2 CH.sub.3                                                                      CH.sub.3                                                                            H  OCH.sub.3                                                                         OCH.sub.3                                                                           N                                                SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                            H  CH.sub.3                                                                          OCH.sub.3                                                                           CH                                               C.sub.6 H.sub. 5                                                                        CH.sub.3                                                                            H  OCH.sub.3                                                                         OCH.sub.3                                                                           CH                                               CH.sub.2 C.sub.6 H.sub.5                                                                CH.sub.3                                                                            H  CH.sub.3                                                                          OCH.sub.3                                                                           N                                                H         CH.sub.3                                                                            CH.sub.3                                                                         OCH.sub.3                                                                         OCH.sub.3                                                                           N                                                CH.sub.3  CH.sub.3                                                                            CH.sub.3                                                                         CH.sub.3                                                                          OCH.sub.3                                                                           CH                                               CH.sub.3  CH.sub.2 CH.sub.3                                                                   H  OCH.sub.3                                                                         OCH.sub.3                                                                           CH                                               CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                           H  CH.sub.3                                                                          OCH.sub.3                                                                           N                                                H         CH.sub.3                                                                            H  CH.sub.3                                                                          CH.sub.3                                                                            CH                                               CH.sub.3  H     H  Cl  OCH.sub.3                                                                           CH                                               CH.sub.3  CH.sub.3                                                                            H  OCH.sub.3                                                                         N(CH.sub.3).sub.2                                                                   N                                                CH.sub.3  CH.sub.3                                                                            H  OCH.sub.3                                                                         OCH.sub.2 CF.sub.3                                                                  CH                                               CH.sub.3  CH.sub.3                                                                            H  OCH.sub.3                                                                         OCF.sub.2 H                                                                         CH                                               __________________________________________________________________________

                                      TABLE 16                                    __________________________________________________________________________    General Structure 16                                                          R.sub.1                                                                            R.sub.2                                                                              R.sub.3                                                                            A  R  X.sub.1,2,3, or 4                                                                   Y.sub.1,2,3, or 4                                                                  m.p. (°C.)                           __________________________________________________________________________    H    SO.sub.2 CH.sub.3                                                                    H    A-2                                                                              H  CH.sub.3                                                                            O                                                CH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                    H    A-2                                                                              H  CH.sub.3                                                                            O                                                CH.sub.2 CH.sub.3                                                                  SO.sub.2 N(CH.sub.3).sub.2                                                           H    A-2                                                                              H  CH.sub.3                                                                            O                                                CH.sub.2 CF.sub.3                                                                  NO.sub.2                                                                             H    A-2                                                                              H  CH.sub.3                                                                            O                                                CF.sub.2 H                                                                         SO.sub.2 CH.sub.3                                                                    H    A-2                                                                              H  CH.sub.3                                                                            O                                                H    SO.sub.2 N(CH.sub.3).sub.2                                                           H    A-2                                                                              H  OCH.sub.3                                                                           CH.sub.2                                         CH.sub.3                                                                           OSO.sub.2 CH.sub.3                                                                   H    A-2                                                                              H  OCH.sub.3                                                                           CH.sub.2                                         H    CO.sub.2 CH.sub.2 CH.sub.3                                                           H    A-2                                                                              H  H     O                                                CH.sub.3                                                                           NO.sub.2                                                                             H    A-2                                                                              H  H     O                                                H    SO.sub.2 N(CH.sub.3).sub.2                                                           H    A-2                                                                              H  OCH.sub.3                                                                           O                                                CH.sub.3                                                                           OSO.sub.2 CH.sub.3                                                                   H    A-2                                                                              H  OCH.sub.3                                                                           O                                                CH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                    5-OCH.sub.3                                                                        A-2                                                                              H  OCH.sub.3                                                                           O                                                H    NO.sub.2                                                                             H    A-2                                                                              CH.sub.3                                                                         CH.sub. 3                                                                           O                                                H    SO.sub.2 CH.sub.3                                                                    H    A-3                                                                              H  CH.sub.3                                                                            --                                               CH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                           H    A-3                                                                              H  CH.sub.3                                                                            --                                               CH.sub.2 CH.sub.3                                                                  CO.sub.2 CH.sub.3                                                                    H    A-3                                                                              H  CH.sub.3                                                                            --                                               CH.sub.2 CF.sub.3                                                                  SO.sub.2 CH.sub.3                                                                    H    A-3                                                                              H  CH.sub.3                                                                            --                                               CF.sub.2 H                                                                         OSO.sub.2 CH.sub.3                                                                   H    A-3                                                                              H  CH.sub.3                                                                            --                                               H    SO.sub.2 N(CH.sub.3).sub.2                                                           H    A-3                                                                              H  H     --                                               CH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                    H    A-3                                                                              H  H     --                                               H    SO.sub.2 CH.sub.3                                                                    H    A-3                                                                              H  OCH.sub.3                                                                           --                                               CH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                           H    A-3                                                                              H  OCH.sub.3                                                                           --                                               CH.sub.2 CF.sub.3                                                                  OSO.sub.2 CH.sub.3                                                                   H    A-3                                                                              H  OCH.sub.3                                                                           --                                               CF.sub.2 H                                                                         CO.sub.2 CH.sub.3                                                                    H    A-3                                                                              H  OCH.sub.3                                                                           --                                               SO.sub.2 CH.sub.3                                                                  SO.sub.2 N(CH.sub.3).sub.2                                                           H    A-3                                                                              H  OCH.sub.3                                                                           --                                               H    OSO.sub.2 CH.sub.3                                                                   H    A-4                                                                              H  CH.sub.3                                                                            CH.sub.3                                         CH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                    H    A-4                                                                              H  CH.sub.3                                                                            CH.sub.3                                         CH.sub.2 CH.sub.3                                                                  CO.sub.2 CH.sub.3                                                                    H    A-4                                                                              H  CH.sub.3                                                                            CH.sub.3                                         CH.sub.2 CF.sub.3                                                                  NO.sub.2                                                                             H    A-4                                                                              H  CH.sub.3                                                                            CH.sub.3                                         CF.sub.2 H                                                                         SO.sub.2 CH.sub.3                                                                    H    A-4                                                                              H  CH.sub.3                                                                            CH.sub.3                                         H    SO.sub.2 N(CH.sub.3).sub.2                                                           H    A-4                                                                              H  OCH.sub.3                                                                           CH.sub.3                                         CH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                    H    A-4                                                                              H  OCH.sub.3                                                                           CH.sub.3                                         H    NO.sub.2                                                                             H    A-4                                                                              H  H     CH.sub.3                                         CH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                    H    A-4                                                                              H  H     CH.sub.3                                         H    SO.sub.2 N(CH.sub.3).sub.2                                                           H    A-4                                                                              H  CH.sub.3                                                                            H                                                CH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                    H    A-4                                                                              H  CH.sub.3                                                                            H                                                H    SO.sub.2 CH.sub.3                                                                    H    A-4                                                                              H  OCH.sub.3                                                                           H                                                CH.sub.3                                                                           OSO.sub.2 CH.sub.3                                                                   H    A-4                                                                              H  OCH.sub.3                                                                           H                                                H    CO.sub.2 CH.sub.3                                                                    H    A-4                                                                              H  H     H                                                CH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                           H    A-4                                                                              H  H     H                                                H    SO.sub.2 CH.sub.3                                                                    H    A-5                                                                              H  CH.sub.3                                                                            OCH.sub.3                                        CH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                    H    A-5                                                                              H  C.sub.2 H.sub.5                                                                     SCH.sub.3                                        C.sub.2 H.sub.5                                                                    SO.sub.2 N(CH.sub.3).sub.2                                                           H    A-5                                                                              H  CH.sub.2 CF.sub. 3                                                                  OCF.sub.2 H                                      H    SO.sub.2 CH.sub.3                                                                    H    A-6                                                                              H  CH.sub.3                                                                            --                                               CH.sub.3                                                                           NO.sub.2                                                                             H    A-6                                                                              H  OCH.sub.3                                                                           --                                               CF.sub.2 H                                                                         CO.sub.2 CH.sub.3                                                                    H    A-6                                                                              H  CH.sub.3                                                                            --                                               H    SO.sub.2 N(CH.sub.3).sub.2                                                           H    A-7                                                                              H  OCH.sub.3                                                                           OCH.sub.3                                        CH.sub.3                                                                           NO.sub.2                                                                             H    A-7                                                                              H  Cl    OCH.sub.3                                        C.sub.2 H.sub.5                                                                    Cl     H    A-7                                                                              H  CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                         CH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.3                                                                    H    A-7                                                                              H  CH.sub.3                                                                            Cl                                               __________________________________________________________________________

                                      TABLE 17                                    __________________________________________________________________________    General Structure 17                                                          R.sub.2   R.sub.3                                                                              R  X    Y      Z  m.p. (°C.)                          __________________________________________________________________________    CH.sub.3  H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            CH.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             (CH.sub.2).sub.2 CH.sub.3                                                               H      H  Cl   OCH.sub.3                                                                            CH                                            OCH.sub.3 H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             OCH.sub.2 CH.sub.3                                                                      H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             O(CH.sub.2).sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            Cl        H      H  Cl   OCH.sub.3                                                                            CH                                            Cl        6-Cl   H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            NO.sub.2  H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CF.sub.3  H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       H      CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       3-CH.sub.3                                                                           H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       5-CH.sub.3                                                                           H  Cl   OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       5-Cl   H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       5-OCH.sub.3                                                                          H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.2 CH.sub.3                                                              5-F    H  Cl   OCH.sub.3                                                                            CH                                            CO.sub.2 CH(CH.sub.3).sub.2                                                             H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            Br        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             SO.sub.2 N(CH.sub.3).sub.2                                                              H      CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              5-Cl   H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 N(OCH.sub.3)CH.sub.3                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             OSO.sub.2 CH.sub.3                                                                      H      H  Cl   OCH.sub.3                                                                            CH                                            OSO.sub.2 CH.sub.2 CH.sub.3                                                             H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                      H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             OCHF.sub.2                                                                              H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             5-methyl-1,3,4-                                                                         H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            oxadiazol-2-yl                                                                5-methyl-1,3,4-                                                                         H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             oxadiazol-2-yl                                                                1,2,3-thiadiazol-                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             4-yl                                                                          1,2,3-thiadiazol-                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            4-yl                                                                          CO.sub.2 CH.sub.2 CH═CH.sub.2                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            Cl        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            Cl        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             Cl        H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             Cl        H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SO.sub.2 CH.sub.3                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             SCH.sub.3 H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            OCHFCHF.sub.2                                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SCF.sub.3 5-Cl   H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            SCH.sub.2 CCl.sub.3                                                                     H      H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             SO.sub.2 CH.sub.2 CH.sub.2 Br                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            COCH.sub.2 CH.sub.3                                                                     5-SCH.sub.3                                                                          H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            S(O)CH.sub.3                                                                            H      H  Cl   OCH.sub.3                                                                            CH                                            CH.sub.2 OCF.sub.3                                                                      H      H  Cl   OCH.sub.3                                                                            CH                                            2-methyl-isoxa-                                                                         H      H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             zol-4-yl                                                                      2-methyl-iso-                                                                           H      H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            thiazol-4-yl                                                                  isothiazol-5-yl                                                                         H      CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             5-methyl-iso-                                                                           H      H  Cl   OCH.sub.3                                                                            CH                                            thiazol-2-yl                                                                  CO.sub.2 CH.sub.3                                                                       5-CH.sub.2 CH.sub.3                                                                  H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            CO.sub.2 CH.sub.3                                                                       5-CH.sub.2 OCH.sub.3                                                                 H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            Cl        6-SCH.sub.3                                                                          H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          CH.sub.2 S(O)CH.sub.3                                                                CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              5-OCF.sub.3                                                                          H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            Cl        5-CH.sub.2 SCH.sub.3                                                                 H  Cl   OCH.sub.3                                                                            CH                                            Cl        5-OCH.sub.2 CHF.sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             Cl        H      H  OCF.sub.2 H                                                                        NH.sub.2                                                                             CH                                            Cl        H      H  OCH.sub.3                                                                          CH.sub.2 SO.sub.2 CH.sub.3                                                           N                                             Cl        H      H  OCH.sub.3                                                                          C.tbd.CH                                                                             N                                             Cl        H      H  OCH.sub.3                                                                          C.tbd.CCH.sub.3                                                                      N                                             __________________________________________________________________________

                                      TABLE 18                                    __________________________________________________________________________    General Structure 18                                                          R.sub.2   R.sub.3                                                                              R  X    Y      Z  m.p. (°C.)                          __________________________________________________________________________    CH.sub.3  H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            CH.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             (CH.sub.2).sub.2 CH.sub.3                                                               H      H  Cl   OCH.sub.3                                                                            CH                                            OCH.sub.3 H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             OCH.sub.2 CH.sub.3                                                                      H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             O(CH.sub.2).sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            Cl        H      H  Cl   OCH.sub.3                                                                            CH                                            Cl        6-Cl   H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            NO.sub.2  H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CF.sub.3  H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       H      CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       3-CH.sub.3                                                                           H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       5-CH.sub.3                                                                           H  Cl   OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       5-Cl   H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       5-OCH.sub.3                                                                          H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.2 CH.sub.3                                                              5-F    H  Cl   OCH.sub.3                                                                            CH                                            CO.sub.2 CH(CH.sub.3).sub.2                                                             H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            Br        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             SO.sub.2 N(CH.sub.3).sub.2                                                              H      CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              5-Cl   H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 N(OCH.sub.3)CH.sub.3                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             OSO.sub.2 CH.sub.3                                                                      H      H  Cl   OCH.sub.3                                                                            CH                                            OSO.sub.2 CH.sub.2 CH.sub.3                                                             H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                      H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             OCHF.sub.2                                                                              H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             5-methyl-1,3,4-                                                                         H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            oxadiazol-2-yl                                                                5-methyl-1,3,4-                                                                         H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             oxadiazol-2-yl                                                                1,2,3-thiadiazol-                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             4-yl                                                                          1,2,3-thiadiazol-                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            4-yl                                                                          CO.sub.2 CH.sub.2 CH═CH.sub.2                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            Cl        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            Cl        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             Cl        H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             Cl        H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SO.sub.2 CH.sub.3                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             SCH.sub.3 H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            OCHFCHF.sub.2                                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SCF.sub.3 5-Cl   H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            SCH.sub.2 CCl.sub.3                                                                     H      H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             SO.sub.2 CH.sub.2 CH.sub.2 Br                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            COCH.sub.2 CH.sub.3                                                                     5-SCH.sub.3                                                                          H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            S(O)CH.sub.3                                                                            H      H  Cl   OCH.sub.3                                                                            CH                                            CH.sub.2 OCF.sub.3                                                                      H      H  Cl   OCH.sub.3                                                                            CH                                            2-methyl-isoxa-                                                                         H      H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             zol-4-yl                                                                      2-methyl-iso-                                                                           H      H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            thiazol-4-yl                                                                  isothiazol-5-yl                                                                         H      CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             5-methyl-iso-                                                                           H      H  Cl   OCH.sub.3                                                                            CH                                            thiazol-2-yl                                                                  CO.sub.2 CH.sub.3                                                                       5-CH.sub.2 CH.sub.3                                                                  H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            CO.sub.2 CH.sub.3                                                                       5-CH.sub.2 OCH.sub.3                                                                 H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            Cl        6-SCH.sub.3                                                                          H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          CH.sub.2 S(O)CH.sub.3                                                                CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              5-OCF.sub.3                                                                          H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            Cl        5-CH.sub.2 SCH.sub.3                                                                 H  Cl   OCH.sub.3                                                                            CH                                            Cl        5-OCH.sub.2 CHF.sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             Cl        H      H  OCF.sub.2 H                                                                        NH.sub.2                                                                             CH                                            Cl        H      H  OCH.sub.3                                                                          CH.sub.2 SO.sub.2 CH.sub.3                                                           N                                             Cl        H      H  OCH.sub.3                                                                          C.tbd.CH                                                                             N                                             Cl        H      H  OCH.sub.3                                                                          C.tbd.CCH.sub.3                                                                      N                                             __________________________________________________________________________

                                      TABLE 19                                    __________________________________________________________________________    General Structure 19                                                          R.sub.2   R.sub.3                                                                              R  X    Y      Z  m.p. (°C.)                          __________________________________________________________________________    CH.sub.3  H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            CH.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             (CH.sub.2).sub.2 CH.sub.3                                                               H      H  Cl   OCH.sub.3                                                                            CH                                            OCH.sub.3 H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             OCH.sub.2 CH.sub.3                                                                      H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             O(CH.sub.2).sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            Cl        H      H  Cl   OCH.sub.3                                                                            CH                                            Cl        6-Cl   H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            NO.sub.2  H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CF.sub.3  H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       H      CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       3-CH.sub.3                                                                           H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       5-CH.sub.3                                                                           H  Cl   OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       5-Cl   H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       5-OCH.sub.3                                                                          H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.2 CH.sub.3                                                              5-F    H  Cl   OCH.sub.3                                                                            CH                                            CO.sub.2 CH(CH.sub.3).sub.2                                                             H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            Br        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             SO.sub.2 N(CH.sub.3).sub.2                                                              H      CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              5-Cl   H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 N(OCH.sub.3)CH.sub.3                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             OSO.sub.2 CH.sub.3                                                                      H      H  Cl   OCH.sub.3                                                                            CH                                            OSO.sub.2 CH.sub.2 CH.sub.3                                                             H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                      H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             OCHF.sub.2                                                                              H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             5-methyl-1,3,4-                                                                         H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            oxadiazol-2-yl                                                                5-methyl-1,3,4-                                                                         H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             oxadiazol-2-yl                                                                1,2,3-thiadiazol-                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             4-yl                                                                          1,2,3-thiadiazol-                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            4-yl                                                                          CO.sub.2 CH.sub.2 CH═CH.sub.2                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            Cl        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            Cl        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             Cl        H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             Cl        H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SO.sub.2 CH.sub.3                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             SCH.sub.3 H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            OCHFCHF.sub.2                                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SCF.sub.3 5-Cl   H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            SCH.sub.2 CCl.sub.3                                                                     H      H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             SO.sub.2 CH.sub.2 CH.sub.2 Br                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            COCH.sub.2 CH.sub.3                                                                     5-SCH.sub.3                                                                          H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            S(O)CH.sub.3                                                                            H      H  Cl   OCH.sub.3                                                                            CH                                            CH.sub.2 OCF.sub.3                                                                      H      H  Cl   OCH.sub.3                                                                            CH                                            2-methyl-isoxa-                                                                         H      H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             zol-4-yl                                                                      2-methyl-iso-                                                                           H      H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            thiazol-4-yl                                                                  isothiazol-5-yl                                                                         H      CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             5-methyl-iso-                                                                           H      H  Cl   OCH.sub.3                                                                            CH                                            thiazol-2-yl                                                                  CO.sub.2 CH.sub.3                                                                       5-CH.sub.2 CH.sub.3                                                                  H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            CO.sub.2 CH.sub.3                                                                       5-CH.sub.2 OCH.sub.3                                                                 H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            Cl        6-SCH.sub.3                                                                          H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          CH.sub.2 S(O)CH.sub.3                                                                CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              5-OCF.sub.3                                                                          H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            Cl        5-CH.sub.2 SCH.sub.3                                                                 H  Cl   OCH.sub.3                                                                            CH                                            Cl        5-OCH.sub.2 CHF.sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             Cl        H      H  OCF.sub.2 H                                                                        NH.sub.2                                                                             CH                                            Cl        H      H  OCH.sub.3                                                                          CH.sub.2 SO.sub.2 CH.sub.3                                                           N                                             Cl        H      H  OCH.sub.3                                                                          C.tbd.CH                                                                             N                                             Cl        H      H  OCH.sub.3                                                                          C.tbd.CCH.sub.3                                                                      N                                             __________________________________________________________________________

                                      TABLE 20                                    __________________________________________________________________________    General Structure 20                                                          R.sub.2   R.sub.3                                                                              R  X    Y      Z  m.p. (°C.)                          __________________________________________________________________________    CH.sub.3  H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            CH.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             (CH.sub.2).sub.2 CH.sub.3                                                               H      H  Cl   OCH.sub.3                                                                            CH                                            OCH.sub.3 H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             OCH.sub.2 CH.sub.3                                                                      H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             O(CH.sub.2).sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            Cl        H      H  Cl   OCH.sub.3                                                                            CH                                            Cl        6-Cl   H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            NO.sub.2  H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CF.sub.3  H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       H      CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       3-CH.sub.3                                                                           H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       5-CH.sub.3                                                                           H  Cl   OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       5-Cl   H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       5-OCH.sub.3                                                                          H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.2 CH.sub.3                                                              5-F    H  Cl   OCH.sub.3                                                                            CH                                            CO.sub.2 CH(CH.sub.3).sub.2                                                             H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            Br        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             SO.sub.2 N(CH.sub.3).sub.2                                                              H      CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              5-Cl   H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 N(OCH.sub.3)CH.sub.3                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             OSO.sub.2 CH.sub.3                                                                      H      H  Cl   OCH.sub.3                                                                            CH                                            OSO.sub.2 CH.sub.2 CH.sub.3                                                             H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                      H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             OCHF.sub.2                                                                              H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             5-methyl-1,3,4-                                                                         H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            oxadiazol-2-yl                                                                5-methyl-1,3,4-                                                                         H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             oxadiazol-2-yl                                                                1,2,3-thiadiazol-                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             4-yl                                                                          1,2,3-thiadiazol-                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            4-yl                                                                          CO.sub.2 CH.sub.2 CH═CH.sub.2                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            Cl        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            Cl        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             Cl        H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             Cl        H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SO.sub.2 CH.sub.3                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             SCH.sub.3 H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            OCHFCHF.sub.2                                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SCF.sub.3 5-Cl   H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            SCH.sub.2 CCl.sub.3                                                                     H      H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             SO.sub.2 CH.sub.2 CH.sub.2 Br                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            COCH.sub.2 CH.sub.3                                                                     5-SCH.sub.3                                                                          H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            S(O)CH.sub.3                                                                            H      H  Cl   OCH.sub.3                                                                            CH                                            CH.sub.2 OCF.sub.3                                                                      H      H  Cl   OCH.sub.3                                                                            CH                                            2-methyl-isoxa-                                                                         H      H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             zol-4-yl                                                                      2-methyl-iso-                                                                           H      H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            thiazol-4-yl                                                                  isothiazol-5-yl                                                                         H      CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             5-methyl-iso-                                                                           H      H  Cl   OCH.sub.3                                                                            CH                                            thiazol-2-yl                                                                  CO.sub.2 CH.sub.3                                                                       5-CH.sub.2 CH.sub.3                                                                  H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            CO.sub.2 CH.sub.3                                                                       5-CH.sub.2 OCH.sub.3                                                                 H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            Cl        6-SCH.sub.3                                                                          H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          CH.sub.2 S(O)CH.sub.3                                                                CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              5-OCF.sub.3                                                                          H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            Cl        5-CH.sub.2 SCH.sub.3                                                                 H  Cl   OCH.sub.3                                                                            CH                                            Cl        5-OCH.sub.2 CHF.sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             Cl        H      H  OCF.sub.2 H                                                                        NH.sub.2                                                                             CH                                            Cl        H      H  OCH.sub.3                                                                          CH.sub.2 SO.sub.2 CH.sub.3                                                           N                                             Cl        H      H  OCH.sub.3                                                                          C.tbd.CH                                                                             N                                             Cl        H      H  OCH.sub.3                                                                          C.tbd.CCH.sub.3                                                                      N                                             __________________________________________________________________________

                                      TABLE 21                                    __________________________________________________________________________    General Structure 21                                                          R.sub.2   R.sub.3                                                                              R  X    Y      Z  m.p. (°C.)                          __________________________________________________________________________    CH.sub.3  H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            CH.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             (CH.sub.2).sub.2 CH.sub.3                                                               H      H  Cl   OCH.sub.3                                                                            CH                                            OCH.sub.3 H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             OCH.sub.2 CH.sub.3                                                                      H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             O(CH.sub.2).sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            Cl        H      H  Cl   OCH.sub.3                                                                            CH                                            Cl        6-Cl   H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            NO.sub.2  H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CF.sub.3  H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       H      CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       3-CH.sub.3                                                                           H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       5-CH.sub.3                                                                           H  Cl   OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       5-Cl   H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.3                                                                       5-OCH.sub.3                                                                          H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             CO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.2 CH.sub.3                                                              5-F    H  Cl   OCH.sub.3                                                                            CH                                            CO.sub.2 CH(CH.sub.3).sub.2                                                             H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            Br        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             SO.sub.2 N(CH.sub.3).sub.2                                                              H      CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              5-Cl   H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 N(OCH.sub.3)CH.sub.3                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             OSO.sub.2 CH.sub.3                                                                      H      H  Cl   OCH.sub.3                                                                            CH                                            OSO.sub.2 CH.sub.2 CH.sub.3                                                             H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                      H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             OCHF.sub.2                                                                              H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             5-methyl-1,3,4-                                                                         H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            oxadiazol-2-yl                                                                5-methyl-1,3,4-                                                                         H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             oxadiazol-2-yl                                                                1,2,3-thiadiazol-                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             4-yl                                                                          1,2,3-thiadiazol-                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            4-yl                                                                          CO.sub.2 CH.sub.2 CH═CH.sub.2                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            Cl        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            Cl        H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             Cl        H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             Cl        H      H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                            SO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SO.sub.2 CH.sub.3                                                                       H      H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                             SCH.sub.3 H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            OCHFCHF.sub.2                                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             SCF.sub.3 5-Cl   H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            SCH.sub.2 CCl.sub.3                                                                     H      H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             SO.sub.2 CH.sub.2 CH.sub.2 Br                                                           H      H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            COCH.sub.2 CH.sub.3                                                                     5-SCH.sub.3                                                                          H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            S(O)CH.sub.3                                                                            H      H  Cl   OCH.sub.3                                                                            CH                                            CH.sub.2 OCF.sub.3                                                                      H      H  Cl   OCH.sub.3                                                                            CH                                            2-methyl-isoxa-                                                                         H      H  OCH.sub.3                                                                          CH.sub.3                                                                             N                                             zol-4-yl                                                                      2-methyl-iso-                                                                           H      H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            thiazol-4-yl                                                                  isothiazol-5-yl                                                                         H      CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             5-methyl-iso-                                                                           H      H  Cl   OCH.sub.3                                                                            CH                                            thiazol-2-yl                                                                  CO.sub.2 CH.sub.3                                                                       5-CH.sub.2 CH.sub.3                                                                  H  OCH.sub.3                                                                          CH.sub.3                                                                             CH                                            CO.sub.2 CH.sub.3                                                                       5-CH.sub.2 OCH.sub.3                                                                 H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            Cl        6-SCH.sub.3                                                                          H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CO.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                          CH.sub.2 S(O)CH.sub.3                                                                CH                                            SO.sub.2 N(CH.sub.3).sub.2                                                              5-OCF.sub.3                                                                          H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                            Cl        5-CH.sub.2 SCH.sub.3                                                                 H  Cl   OCH.sub.3                                                                            CH                                            Cl        5-OCH.sub.2 CHF.sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                             Cl        H      H  OCF.sub.2 H                                                                        NH.sub.2                                                                             CH                                            Cl        H      H  OCH.sub.3                                                                          CH.sub.2 SO.sub.2 CH.sub.3                                                           N                                             Cl        H      H  OCH.sub.3                                                                          C.tbd.CH                                                                             N                                             Cl        H      H  OCH.sub.3                                                                          C.tbd.CCH.sub.3                                                                      N                                             __________________________________________________________________________

                                      TABLE 22                                    __________________________________________________________________________    General Structure 22                                                          R.sub.1    R.sub.2       R.sub.3                                                                            R  X      Y             Z  m.p. (°                                                                C.)                  __________________________________________________________________________    (CH.sub.2).sub.2 CH.sub.3                                                                SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             OCH.sub.3     CH                      CH.sub.2 CH.sub.2 F                                                                      CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            OCH.sub.3     CH                      CH.sub.2 CH.sub.2 F                                                                      SO.sub.2 CH.sub.3                                                                           H    H  Cl     OCH.sub.3     CH                      CH.sub.2 CH.sub.2 CH.sub.2 F                                                             SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             OCH.sub.3     N                       CH.sub.2 CH.sub.2 CH.sub.2 F                                                             CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    H  OCH.sub.3                                                                            OCH.sub.3     N                       CH.sub.2 CH.sub.2 CF.sub.3                                                               SO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                             OCH.sub.3     CH                      CH.sub.2 CHFCH.sub.2 F                                                                   SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                            OCH.sub.3     CH                      CH.sub.2 CH.sub.2 OCH.sub.3                                                              CO.sub.2 CH.sub.3                                                                           H    H  Cl     OCH.sub.3     CH                      CH.sub.2 CH.sub.2 OH                                                                     SO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                             OCH.sub.3     N                       CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                            OCH.sub.3     N                       OH         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             OCH.sub.3     CH                      OSi(CH.sub.3).sub.3                                                                      CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            OCH.sub.3     CH                      OCH.sub.3  SO.sub.2 CH.sub.3                                                                           H    H  Cl     OCH.sub.3     CH                      OCH.sub.2 CH.sub.3                                                                       SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             OCH.sub.3     N                       SO.sub.2 CH.sub.3                                                                        CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            OCH.sub.3     N                       C.sub.6 H.sub.5                                                                          SO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                             OCH.sub.3     CH                      CH.sub.2 C.sub.6 H.sub.5                                                                 SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                            OCH.sub.3     CH                      OCH.sub.3  CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3     CH                      SO.sub.2 CH.sub.3                                                                        SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             OCH.sub.3     N                       CH.sub.2 C.sub.6 H.sub.5                                                                 CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            OCH.sub.3     N                       OCH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             CH.sub.3      CH                      SO.sub.2 CH.sub.3                                                                        SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            N(CH.sub. 3).sub.2                                                                          N                       CH.sub.3   (CH.sub.2).sub.3 CH.sub.3                                                                   H    H  CH.sub.3                                                                             OCH.sub.3     CH                      H          (CH.sub.2).sub.3 CH.sub.3                                                                   H    H  OCH.sub.3                                                                            OCH.sub.3     N                       CH.sub.3   O(CH.sub.2).sub.3 CH.sub.3                                                                  H    H  CH.sub.3                                                                             OCH.sub.3     N                       H          O(CH.sub.2).sub.3 CH.sub.3                                                                  H    H  OCH.sub.3                                                                            OCH.sub.3     CH                      CH.sub.3   OCH.sub.2 CH.sub.2 OCH.sub.3                                                                H    H  CH.sub.3                                                                             OCH.sub.3     N                       H          OCH.sub.2 CH.sub.2 OCH.sub.3                                                                H    H  OCH.sub.3                                                                            OCH.sub.3     CH                      CH.sub.3   F             H    H  CH.sub.3                                                                             OCH.sub.3     CH                      H          F             H    H  OCH.sub.3                                                                            OCH.sub.3     N                       CH.sub.3   CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                          H    H  CH.sub.3                                                                             OCH.sub.3     N                       H          CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                          H    H  OCH.sub.3                                                                            OCH.sub.3     CH                      CH.sub.3   CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                        H    H  CH.sub.3                                                                             OCH.sub.3     CH                      H          CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                        H    H  OCH.sub.3                                                                            OCH.sub.3     N                       CH.sub.3   CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                               H    H  CH.sub.3                                                                             OCH.sub.3     CH                      H          CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                               H    H  OCH.sub.3                                                                            OCH.sub.3     N                       CH.sub.3   OCF.sub.3     H    H  OCH.sub.3                                                                            OCH.sub.3     N                       H          OCF.sub.3     H    H  CH.sub.3                                                                             OCH.sub.3     CH                      CH.sub.3   SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                         H    H  OCH.sub.3                                                                            OCH.sub.3     CH                      H          SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                         H    H  CH.sub.3                                                                             OCH.sub.3     N                       CH.sub.3   SO.sub.2 N(CH.sub.3)(CH.sub.2).sub.2 CH.sub.3                                               H    H  OCH.sub.3                                                                            OCH.sub.3     N                       H          SO.sub.2 N(CH.sub.3)(CH.sub.2).sub.2 CH.sub.3                                               H    H  CH.sub.3                                                                             OCH.sub.3     CH                      CH.sub.3   OSO.sub.2 N(CH.sub.3).sub.2                                                                 H    H  CH.sub.3                                                                             OCH.sub.3     CH                      H          OSO.sub.2 N(CH.sub.3).sub.2                                                                 H    H  OCH.sub.3                                                                            OCH.sub.3     N                       CH.sub.3   OSO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                         H    H  CH.sub.3                                                                             OCH.sub.3     N                       H          OSO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                         H    H  OCH.sub.3                                                                            OCH.sub.3     CH                      CH.sub.3   SO.sub.2 CH.sub.2 CH═CH.sub.2                                                           H    H  CH.sub.3                                                                             OCH.sub.3     CH                      H          SO.sub.2 CH.sub.2 CH═CH.sub.2                                                           H    H  OCH.sub.3                                                                            OCH.sub.3     N                       CH.sub.3   SCF.sub.3     H    H  OCH.sub.3                                                                            OCH.sub. 3    N                       H          SCF.sub.3     H    H  CH.sub.3                                                                             OCH.sub.3     CH                      CH.sub.3   SO.sub.2 CF.sub.3                                                                           H    H  CH.sub.3                                                                             OCH.sub.3     CH                      H          SO.sub.2 CF.sub.3                                                                           H    H  OCH.sub.3                                                                            OCH.sub.3     N                       CH.sub.3   SCF.sub.2 H   H    H  CH.sub.3                                                                             OCH.sub.3     N                       H          SCF.sub.2 H   H    H  Cl     OCH.sub.3     CH                      CH.sub.3   SO.sub.2 CF.sub.2 H                                                                         H    H  OCH.sub.3                                                                            OCH.sub.3     CH                      H          SO.sub.2 CF.sub.2 H                                                                         H    H  CH.sub.3                                                                             OCH.sub.3     N                       CH.sub.3   OCH.sub.2 CH═CH.sub.2                                                                   H    H  CH.sub.3                                                                             OCH.sub.3     N                       H          OCH.sub.2 CH═CH.sub.2                                                                   H    H  OCH.sub.3                                                                            OCH.sub.3     CH                      CH.sub.3   OCH.sub.2 CH═CHCH.sub.3                                                                 H    H  CH.sub.3                                                                             OCH.sub.3     CH                      H          OCH.sub.2 CH═CHCH.sub.3                                                                 H    H  OCH.sub.3                                                                            OCH.sub.3     N                       CH.sub.3   OCH.sub.2 C.tbd.CH                                                                          H    H  OCH.sub.3                                                                            OCH.sub.3     N                       H          OCH.sub.2 C.tbd.CH                                                                          H    H  CH.sub.3                                                                             OCH.sub.3     CH                      CH.sub.3   OCH.sub.2 C.tbd.CCH.sub.3                                                                   H    H  OCH.sub.3                                                                            OCH.sub.3     CH                      H          OCH.sub.2 C.tbd.CCH.sub.3                                                                   H    H  CH.sub.3                                                                             OCH.sub.3     N                       CH.sub.3   CH.sub.2 OCH.sub.3                                                                          H    H  CH.sub.3                                                                             OCH.sub.3     N                       H          CH.sub.2 OCH.sub.3                                                                          H    H  OCH.sub.3                                                                            OCH.sub.3     CH                      CH.sub.3   CH.sub.2 OCH.sub.2 CH.sub.3                                                                 H    H  CH.sub.3                                                                             OCH.sub.3     CH                      H          CH.sub.2 OCH.sub.2 CH.sub.3                                                                 H    H  OCH.sub.3                                                                            OCH.sub.3     N                       CH.sub.3   (CH.sub.2).sub.2 OCH.sub.3                                                                  H    H  CH.sub.3                                                                             OCH.sub.3     CH                      H          (CH.sub.2).sub.2 OCH.sub.3                                                                  H    H  OCH.sub.3                                                                            OCH.sub.3     N                       CH.sub.3   (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3                                                         H    H  CH.sub.3                                                                             OCH.sub.3     N                       H          (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3                                                         H    H  OCH.sub.3                                                                            OCH.sub.3     CH                      CH.sub.3   C.sub.6 H.sub.5                                                                             H    H  CH.sub.3                                                                             OCH.sub.3     CH                      H          C.sub.6 H.sub.5                                                                             H    H  OCH.sub.3                                                                            OCH.sub.3     N                       CH.sub.3   1,3,4,oxadiazol-2-yl                                                                        H    H  OCH.sub.3                                                                            OCH.sub.3     N                       H          1,3,4-oxadiazol-2-yl                                                                        H    H  CH.sub.3                                                                             OCH.sub.3     CH                      CH.sub.3   5-isoxazolyl  H    H  OCH.sub.3                                                                            OCH.sub.3     CH                      H          5-isoxazolyl  H    H  CH.sub.3                                                                             OCH.sub.3     N                       CH.sub.3   3-isoxazolyl  H    H  CH.sub.3                                                                             OCH.sub.3     N                       H          3-isoxazolyl  H    H  OCH.sub.3                                                                            OCH.sub.3     CH                      CH.sub.3   4-isoxazolyl  H    H  CH.sub.3                                                                             OCH.sub.3     CH                      H          4-isoxazolyl  H    H  OCH.sub.3                                                                            OCH.sub.3     N                       CH.sub.3   1-methyl-1H--pyrazol-3-yl                                                                   H    H  OCH.sub.3                                                                            OCH.sub.3     N                       H          1-methyl-1H--pyrazol-3-yl                                                                   H    H  CH.sub.3                                                                             OCH.sub.3     CH                      CH.sub.3   1H--pyrazol-1-yl                                                                            H    H  OCH.sub.3                                                                            OCH.sub.3     CH                      H          1H--pyrazol-1-yl                                                                            H    H  CH.sub.3                                                                             OCH.sub.3     N                       CH.sub.3   1H--1,2,4-triazol-1-yl                                                                      H    H  CH.sub.3                                                                             OCH.sub.3     N                       H          1H--1,2,4-triazol-1-yl                                                                      H    H  OCH.sub.3                                                                            OCH.sub.3     CH                      CH.sub.3   tetrahydro-2-furanyl                                                                        H    H  CH.sub.3                                                                             OCH.sub.3     CH                      H          tetrahydro-2-furanyl                                                                        H    H  OCH.sub.3                                                                            OCH.sub.3     N                       CH.sub.3   2-furanyl     H    H  CH.sub.3                                                                             OCH.sub.3     N                       H          2-furanyl     H    H  OCH.sub.3                                                                            OCH.sub.3     CH                      CH.sub.3   2-thienyl     H    H  CH.sub.3                                                                             OCH.sub.3     CH                      H          2-thienyl     H    H  OCH.sub.3                                                                            OCH.sub.3     N                       CH.sub.3   SO.sub.2 N(CH.sub.3).sub.2                                                                  5-F  H  CH.sub.3                                                                             OCH.sub.3     N                       H          CO.sub.2 CH.sub.3                                                                           3-F  H  OCH.sub.3                                                                            OCH.sub.3     CH                      CH.sub.3   CO.sub.2 CH.sub.3                                                                           3-Cl H  OCH.sub.3                                                                            OCH.sub.3     CH                      H          OCF.sub.2 H   6-Cl H  CH.sub.3                                                                             OCH.sub.3     N                       CH.sub.3   SO.sub.2 CH.sub.3                                                                           6-Br H  CH.sub.3                                                                             OCH.sub.3     N                       H          SO.sub.2 N(CH.sub.3).sub.2                                                                  5-Br H  OCH.sub.3                                                                            OCH.sub.3     CH                      CH.sub.3   CO.sub.2 CH.sub.2 CH.sub.3                                                                  5-CF.sub.3                                                                         H  OCH.sub.3                                                                            OCH.sub.3     CH                      H          Cl            6-CF.sub.3                                                                         H  CH.sub.3                                                                             OCH.sub.3     N                       CH.sub.3   OSO.sub.2 CH.sub.3                                                                          6-CH.sub.3                                                                         H  OCH.sub.3                                                                            OCH.sub.3     N                       H          SO.sub.2 N(CH.sub.3).sub.2                                                                  5-CH.sub.3                                                                         H  CH.sub.3                                                                             OCH.sub.3     CH                      CH.sub.3   SO.sub.2 CH.sub.3                                                                           3-OCH.sub.3                                                                        H  OCH.sub.3                                                                            OCH.sub.3     CH                      H          CO.sub.2 CH.sub.3                                                                           5-OCH.sub.3                                                                        H  CH.sub.3                                                                             OCH.sub.3     N                       CH.sub.3   SO.sub.2 CH.sub.3                                                                           6-OCF.sub.2 H                                                                      H  CH.sub.3                                                                             OCH.sub.3     N                       H          SO.sub.2 N(CH.sub.3).sub.2                                                                  5-OCF.sub.2 H                                                                      H  OCH.sub.3                                                                            OCH.sub.3     CH                      CH.sub.3   CO.sub.2 CH.sub.3                                                                           5-OC.sub.2 H.sub.5                                                                 H  CH.sub.3                                                                             OCH.sub.3     CH                      H          SO.sub.2 N(CH.sub.3).sub.2                                                                  6-OC.sub.2 H.sub.5                                                                 H  OCH.sub.3                                                                            OCH.sub.3     N                       CH.sub.3   OCH.sub.2 CH.sub.3                                                                          6-Cl CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3     N                       H          SO.sub.2 N(CH.sub.3).sub.2                                                                  5-OCH.sub.3                                                                        CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3     CH                      CH.sub.3   CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    H  CH.sub.3                                                                             CH.sub.3      CH                      H          SO.sub. 2 N(CH.sub.3).sub.2                                                                 H    H  OCH.sub.3                                                                            OC.sub.2 H.sub.5                                                                            N                       CH.sub.3   SO.sub.2 CH.sub.3                                                                           H    H  OC.sub.2 H.sub.5                                                                     CH.sub.3      N                       H          OSO.sub.2 CH.sub.3                                                                          H    H  OC.sub.2 H.sub.5                                                                     OC.sub.2 H.sub.5                                                                            CH                      CH.sub.3   CO.sub.2 CH.sub.3                                                                           H    H  Cl     OCH.sub.3     CH                      H          SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  Cl     OC.sub.2 H.sub.5                                                                            CH                      CH.sub.3   SO.sub.2 CH.sub.3                                                                           H    H  F      OCH.sub.3     CH                      H          SO.sub.2 N(OCH.sub.3)CH.sub.3                                                               H    H  F      OCH.sub.3     CH                      CH.sub.3   CO.sub.2 CH.sub.3                                                                           H    H  Br     OCH.sub.3     CH                      H          OSO.sub.2 CH.sub.3                                                                          H    H  Br     OCH.sub.3     CH                      CH.sub.3   NO.sub.2      H    H  I      OCH.sub.3     CH                      H          CO.sub.2 CH.sub.3                                                                           H    H  I      OCH.sub.3     CH                      CH.sub.3   SO.sub.2 CH.sub.3                                                                           H    H  OCF.sub.2 H                                                                          CH.sub.3      CH                      H          SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCF.sub.2 H                                                                          OCF.sub.2 H   CH                      CH.sub.3   CO.sub.2 CH.sub.3                                                                           H    H  CH.sub.2 F                                                                           CH.sub.3      N                       H          Cl            6-Cl H  CH.sub.2 F                                                                           OCH.sub.3     CH                      CH.sub.3   SO.sub.2 N(CH.sub. 3).sub.2                                                                 H    H  OCH.sub.2 CH.sub.2 F                                                                 OCH.sub.3     CH                      H          SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.2 CH.sub.2 F                                                                 CH.sub.3      N                       CH.sub.3   CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    H  OCH.sub.2 CHF.sub.2                                                                  CH.sub.3      N                       H          NO.sub.2      H    H  OCH.sub.2 CHF.sub.2                                                                  OCH.sub.3     CH                      CH.sub.3   CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.2 CF.sub.3                                                                   OCH.sub.3     CH                      H          OSO.sub.2 CH.sub.3                                                                          H    H  OCH.sub.2 CF.sub.3                                                                   CH.sub.3      N                       CH.sub.3   SO.sub.2 CH.sub.3                                                                           H    H  CF.sub.3                                                                             CH.sub.3      CH                      H          SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CF.sub.3                                                                             OCH.sub.3     CH                      CH.sub.3   CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            H             CH                      CH.sub.3   NO.sub.2      H    H  CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                            N                       CH.sub.3   OSO.sub.2 CH.sub.3                                                                          H    H  OCH.sub.3                                                                            CH.sub.2 OCH.sub.3                                                                          N                       H          SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                          CH                      CH.sub.3   CO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                             CH.sub.2 OCH.sub.2 CH.sub.3                                                                 CH                      H          SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                            CH.sub.2 OCH.sub.                                                                           N CH.sub.3              CH.sub.3   SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            NHCH.sub.3    N                       H          OSO.sub.2 CH.sub.3                                                                          H    H  OCH.sub.3                                                                            NHCH.sub.3    CH                      CH.sub.3   CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            N(OCH.sub.3)CH.sub.3                                                                        N                       H          SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            N(CH.sub.3).sub.2                                                                           N                       CH.sub.3   NO.sub.2      H    H  OCH.sub.3                                                                            N(CH.sub.3).sub.2                                                                           CH                      H          SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             C.sub.2 H.sub.5                                                                             CH                      CH.sub.3   CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    H  OCH.sub.3                                                                            C.sub.2 H.sub.5                                                                             N                       H          SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            CF.sub.3      N                       CH.sub.3   CO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                             CF.sub.3      CH                      H          OSO.sub.2 CH.sub.3                                                                          H    H  CH.sub.3                                                                             SCH.sub.3     CH                      CH.sub.3   SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                            SCH.sub.3     N                       H          CO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                             OCH.sub.2 C.tbd.CH                                                                          N                       CH.sub.3   SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            OCH.sub.2 C.tbd.CH                                                                          CH                      H          SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                            OCH.sub.2 CH═CH.sub.                                                                    CH                      CH.sub.3   NO.sub.2      H    H  CH.sub.3                                                                             OCH.sub.2 CH═CH.sub.2                                                                   N                       H          OSO.sub.2 CH.sub.3                                                                          H    H  OCH.sub.3                                                                            OCH.sub.2 CH.sub.2 OCH.sub.3                                                                N                       CH.sub.3   CO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                             OCH.sub.2 CH.sub.2 OCH.sub.3                                                                CH                      H          SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            CH.sub.2 SCH.sub.3                                                                          CH                      CH.sub.3   NO.sub.2      H    H  OCH.sub.3                                                                            CH.sub.2 SCH.sub.3                                                                          N                       CH.sub.3   SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             OCF.sub.2 H   CH                      CH.sub.3   CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            SCF.sub.2 H   CH                      H          SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            SCF.sub.2 H   N                       CH.sub.3   CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            cyclopropyl   N                       H          SO.sub.2 N(CH.sub.3)2                                                                       H    H  OCH.sub.3                                                                            cyclopropyl   CH                      CH.sub.3   CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            dimethoxymethyl                                                                             N                       H          SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             dimethoxymethyl                                                                             CH                      CH.sub.3   SO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                             ethoxymethoxymethyl                                                                         CH                      H          NO.sub.2      H    H  OCH.sub.3                                                                            ethoxymethoxymethyl                                                                         CH                      CH.sub.3   CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    H  CH.sub. 3                                                                            diethoxymethyl                                                                              CH                      H          OSO.sub.2 CH.sub.3                                                                          H    H  OCH.sub.3                                                                            diethoxymethyl                                                                              CH                      CH.sub.3   SO.sub.2 CH.sub.2                                                                           H    H  OCH.sub.3                                                                            1,1-dimethoxyethyl                                                                          CH                      H          SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             1,1-dimethoxyethyl                                                                          CH                      CH.sub.3   OSO.sub.2 CH.sub.3                                                                          H    H  CH.sub.3                                                                             methoxy(methylthio)methyl                                                                   CH                      H          CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            methoxy(methylthio)methyl                                                                   CH                      CH.sub.3   SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                            bis(methylthio)methyl                                                                       CH                      H          SO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                             bis(methylthio)methyl                                                                       CH                      CH.sub.3   CO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                             1,3-dioxolan-2-yl                                                                           CH                      H          SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            1,3,dioxolan-2-yl                                                                           N                       CH.sub.3   SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             2-methyl-1,3- CH                                                              dioxolan-2-yl                         H          NO.sub.2      H    H  OCH.sub.3                                                                            2-methyl-1,3- CH                                                              dioxolan-2-yl                         CH.sub.3   CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            1,3-dioxan-2-yl                                                                             CH                      H          OSO.sub.2 CH.sub.3                                                                          H    H  CH.sub.3                                                                             1,3-dioxan-2-yl                                                                             CH                      CH.sub.3   SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             1,3-oxathiolan-2-yl                                                                         CH                      H          SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            1,3-oxathiolan-2-yl                                                                         CH                      CH.sub.3   CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            1,3-dithiolan-2-yl                                                                          CH                      H          OSO.sub.2 CH.sub.3                                                                          H    H  CH.sub.3                                                                             1,3-dithiolan-2-yl                                                                          CH                      CH.sub.3   SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                             4-methyl-1,3- CH                                                              dioxolan-2-yl                         H          OSO.sub.2 CH.sub.3                                                                          H    H  OCH.sub.3                                                                            4-methyl-1,3- CH                                                              dioxolan-2-yl                         CH.sub.3   NO.sub.2      H    H  OCH.sub.3                                                                            2,4-dimethyl-1,3-                                                                           CH                                                              dioxolan-2-yl                         H          CO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                             2,4-dimethyl-1,3-                                                                           CH                                                              dioxolan-2-yl                         CH.sub.3   OSO.sub.2 CH.sub.3                                                                          H    H  CH.sub.3                                                                             5-methyl-1,3- CH                                                              oxathiolan-2-yl                       H          SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                            5-methyl-1,3- CH                                                              oxathiolan-2-yl                       CH.sub.3   SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            4-methyl-1,3- CH                                                              oxathiolan-2-yl                       H          NO.sub.2      H    H  CH.sub.3                                                                             4-methyl-1,3- CH                                                              oxathiolan-2-yl                       CH.sub.3   CO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                             4-methyl-1,3- CH                                                              dithiolan-2-yl                        H          SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                            4-methyl-1,3- CH                                                              dithiolan-2-yl                        __________________________________________________________________________

                                      TABLE 23                                    __________________________________________________________________________    General Structure 23                                                          R.sub.1   R.sub.4                                                                              R  X    Y    Z  m.p. (°C.)                            __________________________________________________________________________    H         Cl     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                              H         Cl     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                              H         Cl     H  Cl   OCH.sub.3                                                                          CH                                              H         Cl     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                               H         Cl     H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                               H         Cl     CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                          CH                                              CH.sub.3  Cl     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                              CH.sub.3  Cl     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                              CH.sub.3  Cl     H  Cl   OCH.sub.3                                                                          CH                                              CH.sub.3  Cl     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                               CH.sub.3  Cl     H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                               CH.sub.2 CH.sub.3                                                                       Cl     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                              (CH.sub.2).sub.2 CH.sub.3                                                               Cl     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                              CF.sub.2 H                                                                              Cl     H  Cl   OCH.sub.3                                                                          CH                                              CH.sub.2 CF.sub.3                                                                       Cl     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                               CH.sub.2 CH.sub.2 OCH.sub.3                                                             Cl     H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                               CH.sub.2 CH.sub.2 OH                                                                    Cl     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                              CH.sub.2 CH.sub.2 OSi(CH.sub.3 ).sub.3                                                  Cl     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                              OH        Cl     H  Cl   OCH.sub.3                                                                          CH                                              OSi(CH.sub.3).sub.3                                                                     Cl     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                               OCH.sub.3 Cl     H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                               OCH.sub.2 CH.sub.3                                                                      Cl     H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                              SO.sub.2 CH.sub.3                                                                       Cl     H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                              C.sub.6 H.sub.5                                                                         Cl     H  Cl   OCH.sub.3                                                                          CH                                              CH.sub.2 C.sub.6 H.sub.5                                                                Cl     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                               CH.sub.3  H      H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                               CH.sub.3  CH.sub.3                                                                             H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                              CH.sub.3  OCH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                              CH.sub.3  F      H  Cl   OCH.sub.3                                                                          CH                                              CH.sub.3  Br     H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                               CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                           H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                               CH.sub.3  OSO.sub.2 CH.sub.3                                                                   H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                              CH.sub.3  SO.sub.2 CH.sub.3                                                                    H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                              CH.sub.3  Cl     H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  N                                               CH.sub.3  Cl     H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                              CH.sub.3  Cl     H  OCH.sub.3                                                                          OCF.sub.2 H                                                                        CH                                              CH.sub.3  Cl     H  OCF.sub.2 H                                                                        OCF.sub.2 H                                                                        CH                                              H         Cl     H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                              H         Cl     H  OCH.sub.3                                                                          C.tbd.CH                                                                           CH                                              __________________________________________________________________________

                                      TABLE 24                                    __________________________________________________________________________    General Structure 24                                                          R.sub.1   R.sub.5     R  X    Y      Z  m.p. (°C.)                     __________________________________________________________________________    H         SO.sub.2 N(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                       H         SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                       H         SO.sub.2 N(CH.sub.3).sub.2                                                                H  Cl   OCH.sub.3                                                                            CH                                       H         SO.sub.2 N(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                        H         SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                        H         SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                       CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                       CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                       CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  Cl   OCH.sub.3                                                                            CH                                       CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                        CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                        CH.sub.2 CH.sub.3                                                                       SO.sub.2 N(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                       (CH.sub.2).sub.2 CH.sub.3                                                               SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                       CF.sub.2 H                                                                              SO.sub.2 N(CH.sub.3).sub.2                                                                H  Cl   OCH.sub.3                                                                            CH                                       CH.sub.2 CF.sub.3                                                                       SO.sub.2 N(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                        CH.sub.2 CH.sub.2 OCH.sub.3                                                             SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                        CH.sub.2 CH.sub.2 OH                                                                    SO.sub.2 N(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                       CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                       OH        SO.sub.2 N(CH.sub.3).sub.2                                                                H  Cl   OCH.sub.3                                                                            CH                                       OSi(CH.sub.3).sub.3                                                                     SO.sub.2 N(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                        OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                        OCH.sub.2 CH.sub.3                                                                      SO.sub.2 N(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                       SO.sub.2 CH.sub.3                                                                       SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                       C.sub.6 H.sub.5                                                                         SO.sub.2 N(CH.sub.3).sub.2                                                                H  Cl   OCH.sub.3                                                                            CH                                       CH.sub.2 C.sub.6 H.sub.5                                                                SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                        CH.sub.3  CH.sub.3    H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                        CH.sub.3  CH.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                       CH.sub.3  OCH.sub.3   H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                       CH.sub.3  OCH.sub.2 CH.sub.3                                                                        H  Cl   OCH.sub.3                                                                            CH                                       CH.sub.3  F           H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                        CH.sub.3  Cl          H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                        CH.sub.3  Br          H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                       CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                       CH.sub.3  SO.sub.2 N(CH.sub.3)(CH.sub.2).sub.2 CH.sub.3                                             H  Cl   OCH.sub.3                                                                            CH                                       CH.sub.3  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                        CH.sub.3  SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                        CH.sub.3  SO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                       CH.sub.3  SO.sub.2 CH.sub.2 CH.sub.3                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                       CH.sub.3  SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                        H  Cl   OCH.sub.3                                                                            CH                                       CH.sub.3  SO.sub.2 CH.sub.2 CH═CH.sub.2                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                        H         SO.sub.2 CH.sub.3                                                                         H  OCH.sub. 3                                                                         OCH.sub.3                                                                            N                                        H         OCH.sub.2 CH.sub.3                                                                        H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                                       H         Cl          H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                                       H         Br          H  Cl   OCH.sub.3                                                                            CH                                       CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCF.sub.2 H                                                                          CH                                       CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCF.sub.2 H                                                                        OCF.sub.2 H                                                                          CH                                       CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                           CH.sub.3                                                                             CH                                       CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                    N                                        CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          CH.sub.2 SO.sub.2 CH.sub.3                                                           CH                                       __________________________________________________________________________

                                      TABLE 25                                    __________________________________________________________________________    General Structure 25                                                          L  R.sub.1   R.sub.6     R  X    Y    Z  m.p. (°C.)                    __________________________________________________________________________    L-4                                                                              H         CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-4                                                                              H         CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-4                                                                              H         CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-4                                                                              H         CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-4                                                                              H         CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-4                                                                              H         CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.2 CH.sub.3                                                                       CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-4                                                                              (CH.sub.2).sub.2 CH.sub.3                                                               CO.sub.2 CH.sub.3                                                                         H  OCH.sub. 3                                                                         OCH.sub.3                                                                          CH                                      L-4                                                                              CF.sub.2 H                                                                              CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.2 CF.sub.3                                                                       CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-4                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                             CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-4                                                                              CH.sub.2 CH.sub.2 OH                                                                    CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-4                                                                              OH        CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-4                                                                              OSi(CH.sub.3).sub.3                                                                     CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-4                                                                              OCH.sub.3 CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-4                                                                              OCH.sub.2 CH.sub.3                                                                      CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-4                                                                              SO.sub.2 CH.sub.3                                                                       CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-4                                                                              C.sub.6 H.sub.5                                                                         CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  F           H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-4                                                                              CH.sub.3  Cl          H  OCH.sub. 3                                                                         OCH.sub.3                                                                          N                                       L-4                                                                              CH.sub.3  Br          H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  NO.sub.2    H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-4                                                                              CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-4                                                                              CH.sub.3  SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  SO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  N                                       L-4                                                                              CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                                                               H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                        H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      H  Cl   OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.2 CH═CH.sub.2                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-4                                                                              CH.sub.3  SO.sub.2 N(CH.sub.3)(CH.sub.2).sub. 2 CH.sub.3                                            H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  SO.sub.2 CH.sub.2 CH.sub.3                                                                H  Cl   OCH.sub.3                                                                          CH                                      L-4                                                                              CH.sub.3  SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                        H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-4                                                                              CH.sub.3  SO.sub.2 CH.sub.2 CH═CH.sub.2                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                      L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCF.sub.2 H                                                                        CH                                      L-4                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCF.sub.2 H                                                                        OCF.sub.2 H                                                                        N                                       L-5                                                                              H         CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-5                                                                              H         CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-5                                                                              H         CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-5                                                                              H         CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-5                                                                              H         CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-5                                                                              H         CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.2 CH.sub.3                                                                       CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-5                                                                              (CH.sub.2).sub.2 CH.sub.3                                                               CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-5                                                                              CF.sub.2 H                                                                              CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.2 CF.sub.3                                                                       CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-5                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                             CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-5                                                                              CH.sub.2 CH.sub.2 OH                                                                    CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-5                                                                              OH        CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-5                                                                              OSi(CH.sub.3).sub.3                                                                     CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-5                                                                              OCH.sub.3 CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub. 3                                                                         N                                       L-5                                                                              OCH.sub.2 CH.sub.3                                                                      CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-5                                                                              SO.sub.2 CH.sub.3                                                                       CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-5                                                                              C.sub.6 H.sub.5                                                                         CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  F           H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-5                                                                              CH.sub.3  Cl          H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-5                                                                              CH.sub.3  Br          H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  NO.sub.2    H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-5                                                                              CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-5                                                                              CH.sub.3  SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  SO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  N                                       L-5                                                                              CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                                                               H  CH.sub. 3                                                                          OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                        H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      H  Cl   OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.2 CH═CH.sub.2                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-5                                                                              CH.sub.3  SO.sub.2 N(CH.sub.3)(CH.sub.2).sub.2 CH.sub.3                                             H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  SO.sub.2 CH.sub.2 CH.sub.3                                                                H  Cl   OCH.sub.3                                                                          CH                                      L-5                                                                              CH.sub.3  SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                        H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-5                                                                              CH.sub.3  SO.sub.2 CH.sub.2 CH═CH.sub.2                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                      L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCF.sub.2 H                                                                        CH                                      L-5                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCF.sub.2 H                                                                        OCF.sub.2 H                                                                        N                                       L-6                                                                              H         CO.sub.2 CH.sub. 3                                                                        H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-6                                                                              H         CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-6                                                                              H         CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-6                                                                              H         CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-6                                                                              H         CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-6                                                                              H         CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.2 CH.sub.3                                                                       CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-6                                                                              (CH.sub.2).sub.2 CH.sub.3                                                               CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-6                                                                              CF.sub.2 H                                                                              CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.2 CF.sub.3                                                                       CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-6                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                             CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-6                                                                              CH.sub.2 CH.sub.2 OH                                                                    CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-6                                                                              OH        CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-6                                                                              OSi(CH.sub.3).sub.3                                                                     CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-6                                                                              OCH.sub.3 CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-6                                                                              OCH.sub.2 CH.sub.3                                                                      CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-6                                                                              SO.sub.2 CH.sub.3                                                                       CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-6                                                                              C.sub.6 H.sub.5                                                                         CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  F           H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-6                                                                              CH.sub.3  Cl          H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-6                                                                              CH.sub.3  Br          H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  NO.sub.2    H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  CO.sub. 2 CH.sub.2 CH.sub.3                                                               H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-6                                                                              CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-6                                                                              CH.sub.3  SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  SO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  N                                       L-6                                                                              CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                                                               H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                        H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      H  Cl   OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.2 CH═CH.sub.2                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-6                                                                              CH.sub.3  SO.sub.2 N(CH.sub.3)(CH.sub.2).sub.2 CH.sub.3                                             H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub.3  SO.sub.2 CH.sub.2 CH.sub.3                                                                H  Cl   OCH.sub.3                                                                          CH                                      L-6                                                                              CH.sub. 3 SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                        H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                       L-6                                                                              CH.sub.3  SO.sub.2 CH.sub.2 CH═CH.sub.2                                                         H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                       L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                      L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCH.sub.3                                                                          OCF.sub.2 H                                                                        CH                                      L-6                                                                              CH.sub.3  CO.sub.2 CH.sub.3                                                                         H  OCF.sub.2 H                                                                        OCF.sub.2 H                                                                        N                                       __________________________________________________________________________

                                      TABLE 26                                    __________________________________________________________________________    General Structure 26                                                                                                          m.p.                          R.sub.9                                                                          R.sub.1   R.sub.7                                                                             R.sub.8                                                                          R.sub.3                                                                             Q.sub.1                                                                         m R  X    Y    Z  (°C.)                  __________________________________________________________________________    H  H         H     H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  H         H     H  H     O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  H         H     H  H     O 0 H  Cl   OCH.sub.3                                                                          CH                               H  H         H     H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  H         H     H  H     O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  H         H     H  H     O 0 CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  H     O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  H     O 0 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  H     O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.2 CH.sub.3                                                                       H     H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  (CH.sub.2).sub.2 CH.sub.3                                                               H     H  H     O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CF.sub.2 H                                                                              H     H  H     O 0 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.2 CF.sub.3                                                                       H     H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CH.sub.2 CH.sub.2 OCH.sub.3                                                             H     H  H     O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.2 CH.sub.2 OH                                                                    H     H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   H     H  H     O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  OH        H     H  H     O 0 H  Cl   OCH.sub.3                                                                          CH                               H  OSi(CH.sub.3).sub.3                                                                     H     H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  OCH.sub.3 H     H  H     O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  OCH.sub.2 CH.sub.3                                                                      H     H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  SO.sub.2 CH.sub.3                                                                       H     H  H     O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  C.sub.6 H.sub.5                                                                         H     H  H     O 0 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.2 C.sub.6 H.sub.5                                                                H     H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                CH.sub.3                                                                         H         H     H  H     O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                CH.sub.3                                                                         CH.sub.3  H     H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  CH.sub.3                                                                            H  H     O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.3  CH.sub.3                                                                            CH.sub.3                                                                         H     O 0 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.3  CH.sub.2 CH.sub.3                                                                   H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                           H  H     O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.3  (CH.sub.2).sub.3 CH.sub.3                                                           H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  5-F   O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  6-Cl  O 0 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  5-Br  O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  5-CF.sub.3                                                                          O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  6-CH.sub.3                                                                          O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  5-OCH.sub.3                                                                         O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  6-OCF.sub.2 H                                                                       O 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  5-OC.sub.2 H.sub.5                                                                  O 0 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  H     O 0 H  OCF.sub.2 H                                                                        OCF.sub.2 H                                                                        CH                               H  H         H     H  H     O 0 H  OCH.sub.3                                                                          OCF.sub.2 H                                                                        CH                               H  CH.sub.3  H     H  H     O 0 H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  N                                H  CH.sub.3  H     H  H     O 0 H  CH.sub.3                                                                           CH.sub.3                                                                           CH                               H  H         H     H  H     O 1 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  H     O 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.2 CH.sub.3                                                                       H     H  H     O 1 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.2 CF.sub.3                                                                       H     H  H     O 1 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CF.sub.2 H                                                                              H     H  H     O 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.3  CH.sub.3                                                                            CH.sub.3                                                                         H     O 1 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  6-F   O 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  5-Cl  O 1 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  6-Br  O 1 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  6-CF.sub.3                                                                          O 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  5-CH.sub.3                                                                          O 1 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  6-OCH.sub.3                                                                         O 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  5-OCF.sub.2 H                                                                       O 1 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  6-OC.sub.2 H.sub.5                                                                  O 1 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  H         (CH.sub.2).sub.3 CH.sub.3                                                           H  H     O 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  H     O 1 CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  H     O 1 H  CH.sub.3                                                                           CH.sub.3                                                                           CH                               H  CH.sub.3  H     H  H     O 1 H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  N                                H  CH.sub.3  H     H  H     O 1 H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  CH                               H  (CH.sub.2).sub.2 CF.sub.3                                                               H     H  H     O 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  H         H     H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  H         H     H  H     S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  H         H     H  H     S 0 H  Cl   OCH.sub.3                                                                          CH                               H  H         H     H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  H         H     H  H     S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  H         H     H  H     S 0 CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  H     S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  H     S 0 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  H     S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.2 CH.sub.3                                                                       H     H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  (CH.sub.2 ).sub.2 CH.sub.3                                                              H     H  H     S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CF.sub.2 H                                                                              H     H  H     S 0 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.2 CF.sub.3                                                                       H     H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CH.sub.2 CH.sub.2 OCH.sub.3                                                             H     H  H     S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.2 CH.sub.2 OH                                                                    H     H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   H     H  H     S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  OH        H     H  H     S 0 H  Cl   OCH.sub.3                                                                          CH                               H  OSi(CH.sub.3).sub.3                                                                     H     H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  OCH.sub.3 H     H  H     S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  OCH.sub.2 CH.sub.3                                                                      H     H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  SO.sub.2 CH.sub.3                                                                       H     H  H     S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  C.sub.6 H.sub.5                                                                         H     H  H     S 0 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.2 C.sub.6 H.sub.5                                                                H     H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                CH.sub.3                                                                         H         H     H  H     S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                CH.sub.3                                                                         CH.sub.3  H     H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  CH.sub.3                                                                            H  H     S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.3  CH.sub.3                                                                            CH.sub.3                                                                         H     S 0 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.3  CH.sub.2 CH.sub.3                                                                   H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                           H  H     S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.3  (CH.sub.2).sub.3 CH.sub.3                                                           H  H     S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  5-F   S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  6-Cl  S 0 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  5-Br  S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  5-CF.sub.3                                                                          S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  6-CH.sub.3                                                                          S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  5-OCH.sub.3                                                                         S 0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  6-OCF.sub.2 H                                                                       S 0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  5-OC.sub.2 H.sub.5                                                                  S 0 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  H     S 0 H  OCF.sub.2 H                                                                        OCF.sub.2 H                                                                        CH                               H  H         H     H  H     S 0 H  OCH.sub.3                                                                          OCF.sub.2 H                                                                        CH                               H  CH.sub.3  H     H  H     S 0 H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  N                                H  CH.sub.3  H     H  H     S 0 H  CH.sub.3                                                                           CH.sub.3                                                                           CH                               H  H         H     H  H     S 1 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  H     S 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.2 CH.sub.3                                                                       H     H  H     S 1 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.2 CF.sub.3                                                                       H     H  H     S 1 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CF.sub.2 H                                                                              H     H  H     S 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.3  CH.sub.3                                                                            CH.sub.3                                                                         H     S 1 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  6-F   S 1 H  OCH.sub.3                                                                          OCH.sub. 3                                                                         CH                               H  CH.sub.3  H     H  5-Cl  S 1 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  6-Br  S 1 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  6-CF.sub.3                                                                          S 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  5-CH.sub.3                                                                          S 1 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  6-OCH.sub.3                                                                         S 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  5-OCF.sub.2 H                                                                       S 1 H  Cl   OCH.sub.3                                                                          CH                               H  CH.sub.3  H     H  6-OC.sub.2 H.sub.5                                                                  S 1 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                H  H         (CH.sub.2).sub.3 CH.sub.3                                                           H  H     S 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  H     S 1 CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                          N                                H  CH.sub.3  H     H  H     S 1 H  CH.sub.3                                                                           CH.sub.3                                                                           CH                               H  CH.sub.3  H     H  H     S 1 H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  N                                H  CH.sub.3  H     H  H     S 1 H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  CH                               H  (CH.sub.2).sub.2 CF.sub.3                                                               H     H  H     S 0 H  CH.sub. 3                                                                          OCH.sub.3                                                                          CH                               H  H         CH.sub.3                                                                            H  5-OCF.sub.3                                                                         O 1 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               CH.sub.3                                                                         CH.sub.3  H     H  5-SCH.sub.3                                                                         O 0 H  OCH.sub.3                                                                          CH.sub.3                                                                           N                                H  H         H     H  6-CH.sub.2 CH.sub.3                                                                 S 1 H  CH.sub.3                                                                           CH.sub.3                                                                           CH                               __________________________________________________________________________

                                      TABLE 27                                    __________________________________________________________________________    General Structure 27                                                                                                      m.p.                              R.sub.1   R.sub.10                                                                            R.sub.11                                                                         R.sub.3                                                                              Q.sub.2                                                                         R  X    Y    Z  (°C.)                      __________________________________________________________________________    H         H     H  H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                   H         H     H  H      O H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                   H         H     H  H      O H  Cl   OCH.sub.3                                                                          CH                                   H         H     H  H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                    H         H     H  H      O H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                    H         H     H  H      O CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                          N                                    CH.sub.3  H     H  H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                   CH.sub.3  H     H  H      O H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                   CH.sub.3  H     H  H      O H  Cl   OCH.sub.3                                                                          CH                                   CH.sub.3  H     H  H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                    CH.sub.3  H     H  H      O H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                    CH.sub.2 CH.sub.3                                                                       H     H  H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                   (CH.sub.2).sub.2 CH.sub.3                                                               H     H  H      O H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                   CF.sub.2 H                                                                              H     H  H      O H  Cl   OCH.sub.3                                                                          CH                                   CH.sub.2 CF.sub.3                                                                       H     H  H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                    CH.sub.2 CH.sub.2 OCH.sub.3                                                             H     H  H      O H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                    CH.sub.2 CH.sub.2 OH                                                                    H     H  H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                   CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   H     H  H      O H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                   OH        H     H  H      O H  Cl   OCH.sub.3                                                                          CH                                   OSi(CH.sub.3).sub.3                                                                     H     H  H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                    OCH.sub.3 H     H  H      O H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                    OCH.sub.2 CH.sub.3                                                                      H     H  H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                   SO.sub.2 CH.sub.3                                                                       H     H  H      O H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                   C.sub.6 H.sub.5                                                                         H     H  H      O H  Cl   OCH.sub.3                                                                          CH                                   CH.sub.2 C.sub.6 H.sub.5                                                                H     H  H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                    CH.sub.3  CH.sub.3                                                                            H  H      O H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                    CH.sub.3  CH.sub.3                                                                            CH.sub.3                                                                         H      O H  CH.sub. 3                                                                          OCH.sub.3                                                                          CH                                   CH.sub.3  CH.sub.2 CH.sub.3                                                                   H  H      O H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                   CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                           H  H      O H  Cl   OCH.sub.3                                                                          CH                                   CH.sub.3  (CH.sub.2).sub.3 CH.sub.3                                                           H  H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                    CH.sub.3  H     H  5-F    O H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                    CH.sub.3  H     H  6-Cl   O H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                   CH.sub.3  H     H  5-Br   O H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                   CH.sub.3  H     H  6-CF.sub.3                                                                           O H  Cl   OCH.sub.3                                                                          CH                                   CH.sub.3  H     H  5-CH.sub.3                                                                           O H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                    CH.sub.3  H     H  6-OCH.sub.3                                                                          O H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                    CH.sub.3  H     H  5-OCF.sub.2 H                                                                        O H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                   CH.sub.3  H     H  6-OC.sub.2 H.sub.5                                                                   O H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                   H         H     H  H      S H  Cl   OCH.sub.3                                                                          CH                                   CH.sub.3  H     H  H      S H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                    CH.sub.2 CH.sub.3                                                                       H     H  H      S H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                    CH.sub.2 CF.sub.3                                                                       H     H  H      S H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                   CF.sub.2 H                                                                              H     H  H      S H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                                   CH.sub.3  CH.sub.3                                                                            CH.sub.3                                                                         H      S H  Cl   OCH.sub.3                                                                          CH                                   CH.sub.3  H     H  5-Cl   S H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                    CH.sub.3  H     H  5-CF.sub.3                                                                           S H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                    CH.sub.3  H     H  6-CH.sub.3                                                                           S H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                                   CH.sub.3  H     H  H      S H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                   CH.sub.3  H     H  H      O H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  N                                    CH.sub.3  H     H  H      O H  OCH.sub.3                                                                          OCF.sub.2 H                                                                        CH                                   CH.sub.3  H     H  H      O H  OCF.sub.2 H                                                                        OCF.sub.2 H                                                                        CH                                   (CH.sub.2).sub.2 CF.sub.3                                                               H     H  H      O H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                    H         H     H  5-OCF.sub.3                                                                          O H  CH.sub.3                                                                           CH.sub.3                                                                           CH                                   CH.sub.3  H     H  5-C.sub.2 H.sub.5                                                                    S H  Cl   OCH.sub.3                                                                          CH                                   CH.sub.3  H     H  6-CH.sub.2 SCF.sub.3                                                                 O H  Cl   OCH.sub.3                                                                          CH                                   __________________________________________________________________________

                                      TABLE 28                                    __________________________________________________________________________    General Structure 28                                                                                                          m.p.                          L  R.sub.1   R.sub.12 R.sub.3                                                                            R.sub.9                                                                          m R  X    Y    Z  (°C.)                  __________________________________________________________________________    L-9                                                                              H         CH.sub.3 H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-9                                                                              H         CH.sub.3 H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              H         CH.sub.3 H    H  0 H  Cl   OCH.sub.3                                                                          CH                               L-9                                                                              H         CH.sub.3 H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                L-9                                                                              H         CH.sub.3 H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                L-9                                                                              H         CH.sub.3 H    H  0 CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.3  CH.sub.3 H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.3 H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.3 H    H  0 H  Cl   OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.3 H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.3  CH.sub.3 H    H  0 H  OCH.sub. 3                                                                         OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.2 CH.sub.3                                                                       CH.sub.3 H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-9                                                                              (CH.sub.2).sub.2 CH.sub.3                                                               CH.sub.3 H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              CF.sub.2 H                                                                              CH.sub.3 H    H  0 H  Cl   OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.2 CF.sub.3                                                                       CH.sub.3 H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.2 CH.sub.2 CF.sub.3                                                              CH.sub.3 H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                             CH.sub.3 H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.2 CH.sub.2 OH                                                                    CH.sub.3 H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   CH.sub.3 H    H  0 H  Cl   OCH.sub.3                                                                          CH                               L-9                                                                              OH        CH.sub.3 H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                L-9                                                                              OSi(CH.sub.3).sub.3                                                                     CH.sub.3 H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                L-9                                                                              OCH.sub.3 CH.sub.3 H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-9                                                                              OCH.sub.2 CH.sub.3                                                                      CH.sub.3 H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              SO.sub.2 CH.sub.3                                                                       CH.sub.3 H    H  0 H  Cl   OCH.sub.3                                                                          CH                               L-9                                                                              C.sub.6 H.sub.5                                                                         CH.sub.3 H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                CH.sub.3 H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                L-9                                                                              H         H        H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  H        H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.2 CH.sub.3                                                                      H    H  0 H  Cl   OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                              H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.3  (CH.sub.2).sub.3 CH.sub.3                                                              H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.3  (CH.sub.2).sub.4 CH.sub.3                                                              H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  (CH.sub.2).sub.5 CH.sub.3                                                              H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              H         CH.sub.3 H    CH.sub.3                                                                         0 H  Cl   OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.3 H    CH.sub.3                                                                         0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.3  CH.sub.3 6-F  H  0 H  OCH.sub.3                                                                          OCH.sub. 3                                                                         N                                L-9                                                                              CH.sub.3  CH.sub.3 5-Cl H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.3 6-Br H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.3 5-CF.sub.3                                                                         H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.3 6-CH.sub.3                                                                         H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.3  CH.sub.3 5-OCH.sub.3                                                                        H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.3  CH.sub.3 6-OCF.sub.2 H                                                                      H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.3 5-OC.sub.2 H.sub.5                                                                 H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              H         CH.sub.3 H    H  1 H  Cl   OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.3 H    H  1 H  CH.sub.3                                                                           OCH.sub.3                                                                          N                                L-9                                                                              CH.sub.3  CH.sub.3 H    H  1 H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  CH                               L-9                                                                              CH.sub.3  CH.sub.3 H    H  0 H  CH.sub.3                                                                           CH.sub.3                                                                           CH                               L-9                                                                              CH.sub.3  CH.sub.3 H    H  0 H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                  N                                L-9                                                                              CH.sub.3  CH.sub.3 H    H  0 H  OCF.sub.2 H                                                                        CH.sub.3                                                                           CH                               L-9                                                                              CH.sub.3  CH.sub.2 CH.sub.2 Cl                                                                   H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.2 CH.sub.2 Cl                                                                   H    H  0 H  OCH.sub.3                                                                          CH.sub.3                                                                           N                                L-9                                                                              CH.sub.3  CH.sub.2 CH.sub.2 F                                                                    H    H  0 H  OCH.sub.3                                                                          CH.sub.3                                                                           N                                L-9                                                                              CH.sub.3  CH.sub.2 CH.sub.2 F                                                                    H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.2 CF.sub.3                                                                      H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  CH.sub.2 CF.sub.3                                                                      H    H  0 H  OCH.sub.3                                                                          CH.sub.3                                                                           N                                L-9                                                                              CH.sub.3  CH.sub.2 CH.sub.2 Br                                                                   H    H  0 H  OCH.sub.3                                                                          CH.sub.3                                                                           N                                L-9                                                                              CH.sub.3  CH.sub.2 CH.sub.2 OCH.sub.3                                                            H    H  0 H  OCH.sub.3                                                                          CH.sub.3                                                                           N                                L-9                                                                              CH.sub.3  CH.sub.2 CH.sub.2 OCH.sub.3                                                            H    H  0 H  OCH.sub.3                                                                          CH.sub.3                                                                           CH                               L-9                                                                              CH.sub.3  CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                     H    H  0 H  OCH.sub.3                                                                          CH.sub.3                                                                           CH                               L-9                                                                              CH.sub.3  CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                     H    H  0 H  OCH.sub.3                                                                          CH.sub.3                                                                           N                                L-9                                                                              CH.sub.3  (CH.sub.2).sub.3 CH.sub.2 OCH.sub.3                                                    H    H  0 H  OCH.sub.3                                                                          CH.sub.3                                                                           N                                L-9                                                                              CH.sub.3  (CH.sub.2).sub.3 CH.sub.2 Cl                                                           H    H  0 H  OCH.sub.3                                                                          CH.sub.3                                                                           CH                               L-9                                                                              H         CO(CH.sub.2).sub.2 CH.sub.3                                                            H    H  0 H  CH.sub.3                                                                           CH.sub.3                                                                           CH                               L-9                                                                              CH.sub.3  CO.sub.2 C.sub.2 H.sub.5                                                               H    H  0 H  OCH.sub.3                                                                          CH.sub.3                                                                           N                                L-9                                                                              CH.sub.3  CH.sub.2 CF.sub.3                                                                      H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          CH                               L-9                                                                              CH.sub.3  (CH.sub.2).sub.3 CH.sub.2 Br                                                           H    H  0 H  CH.sub.3                                                                           CH.sub.3                                                                           CH                               L-9                                                                              CH.sub.3  CH.sub.2 CH.sub.2 OCH.sub.3                                                            H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                          N                                __________________________________________________________________________

                                      TABLE 28A                                   __________________________________________________________________________    General Structure 28                                                                                                      m.p.                              L  R.sub.1   Q.sub.5                                                                           R.sub.3                                                                            R.sub.9                                                                          m R  X    Y     Z  (°C.)                      __________________________________________________________________________    L-10                                                                             H         O   H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                   L-10                                                                             H         O   H    H  0 H  Cl   OCH.sub.3                                                                           CH                                   L-10                                                                             H         O   H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                    L-10                                                                             H         O   H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                    L-10                                                                             H         O   H    H  0 CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.3  O   H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.3  O   H    H  0 H  Cl   OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.3  NCH.sub.3                                                                         H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                    L-10                                                                             CH.sub.3  NCH.sub.3                                                                         H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                    L-10                                                                             CH.sub.3  NCH.sub.3                                                                         H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.2 CH.sub.3                                                                       NCH.sub.3                                                                         H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                   L-10                                                                             (CH.sub.2).sub.2 CH.sub.3                                                               NH  H    H  0 H  Cl   OCH.sub.3                                                                           CH                                   L-10                                                                             CF.sub.2 H                                                                              NH  H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                    L-10                                                                             CH.sub.2 CF.sub.3                                                                       NH  H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                    L-10                                                                             CH.sub.2 CH.sub.2 CF.sub.3                                                              NH  H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                             NH  H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.2 CH.sub.2 OH                                                                    O   H    H  0 H  Cl   OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   O   H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                    L-10                                                                             OH        O   H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                    L-10                                                                             OSi(CH.sub.3).sub.3                                                                     O   H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                   L-10                                                                             OCH.sub.3 O   H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                   L-10                                                                             OCH.sub.2 CH.sub.3                                                                      O   H    H  0 H  Cl   OCH.sub.3                                                                           CH                                   L-10                                                                             SO.sub.2 CH.sub.3                                                                       O   H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                    L-10                                                                             C.sub.6 H.sub.5                                                                         O   H    H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                    L-10                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                O   H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                   L-10                                                                             H         O   H    CH.sub.3                                                                         0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.3  O   H    CH.sub.3                                                                         0 H  Cl   OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.3  O   5-F  H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                    L-10                                                                             CH.sub.3  O   6-Cl H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                    L-10                                                                             CH.sub.3  O   5-Br H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.3  O   6-CF.sub.3                                                                         H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.3  O   5-CH.sub.3                                                                         H  0 H  Cl   OCH.sub.3                                                                           CH                                   L-10                                                                             H         O   H    H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                   L-10                                                                             H         O   SCH.sub.3                                                                          H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                    L-10                                                                             CH.sub.3  O   6-OCH.sub.3                                                                        H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                    L-10                                                                             CH.sub.3  O   5-OCF.sub.2 H                                                                      H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                    L-10                                                                             CH.sub.3  O   6-OCF.sub.2 H                                                                      H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.3  O   H    H  1 H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                   L-10                                                                             H         O   H    H  1 H  Cl   OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.2 CH.sub.3                                                                       O   H    H  1 H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                    L-10                                                                             CH.sub.2 CF.sub.3                                                                       O   H    H  1 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                    L-10                                                                             CF.sub.2 H                                                                              O   H    H  1 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                   L-10                                                                             CH.sub.3  O   H    H  1 H  OCH.sub.3                                                                          OCF.sub.2 H                                                                         CH                                   L-10                                                                             CH.sub.3  O   H    H  0 H  OCF.sub.2 H                                                                        OCF.sub.2 H                                                                         CH                                   L-10                                                                             CH.sub.3  O   H    H  0 H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                   N                                    L-10                                                                             CH.sub.3  O   H    H  0 H  CH.sub.3                                                                           CH.sub.3                                                                            CH                                   L-10                                                                             CH.sub.3  O   H    H  0 H  OCH.sub.3                                                                          OCH.sub.2 CF.sub.3                                                                  N                                    L-10                                                                             CH.sub.3  O   H    H  0 H  OCH.sub.3                                                                          CH.sub.2 OCH.sub.3                                                                  CH                                   L-10                                                                             CH.sub.3  O   H    H  0 H  CH.sub.3                                                                           CF.sub.3                                                                            CH                                   __________________________________________________________________________

                                      TABLE 28B                                   __________________________________________________________________________    General Structure 28                                                                                                  m.p.                                  L  R.sub.1                                                                            R.sub.26                                                                         R.sub.27                                                                         R.sub.3                                                                             R.sub.9                                                                          m R  X   Y    Z  (°C.)                          __________________________________________________________________________    L-11                                                                             CH.sub.3                                                                           H  Cl 6-F   H  1 H  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                       L-11                                                                             CH.sub.3                                                                           H  Cl 6-Br  H  0 H  OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                       L-11                                                                             CH.sub.3                                                                           H  Cl 5-OC.sub.2 H.sub.5                                                                  H  0 H  CH.sub.3                                                                          OCH.sub.3                                                                          N                                        L-11                                                                             H    H  Cl OCF.sub.3                                                                           H  1 H  OCH.sub.3                                                                         OCH.sub.3                                                                          N                                        L-11                                                                             H    H  Cl CH.sub.2 OCH.sub.3                                                                  H  0 H  Cl  OCH.sub.3                                                                          CH                                       L-11                                                                             H    H  H  H     H  0 H  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                       L-11                                                                             H    H  H  H     H  0 CH.sub.3                                                                         OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                       L-11                                                                             CH.sub.3                                                                           H  H  H     H  0 H  Cl  OCH.sub.3                                                                          CH                                       L-11                                                                             CH.sub.2 CH.sub.3                                                                  H  H  H     H  0 H  CH.sub.3                                                                          OCH.sub.3                                                                          N                                        L-11                                                                             CH.sub.2 CF.sub.3                                                                  H  H  H     H  0 H  OCH.sub.3                                                                         OCH.sub.3                                                                          N                                        L-11                                                                             CF.sub.2 H                                                                         H  H  H     H  0 H  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                       L-11                                                                             OCH.sub.3                                                                          H  H  H     H  0 H  OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                       L-11                                                                             SO.sub.2 CH.sub.3                                                                  H  H  H     H  0 H  Cl  OCH.sub.3                                                                          CH                                       L-11                                                                             CH.sub.3                                                                           H  H  H     CH.sub.3                                                                         0 H  CH.sub.3                                                                          OCH.sub.3                                                                          N                                        L-11                                                                             CH.sub.3                                                                           H  H  5-Cl  H  0 H  OCH.sub.3                                                                         OCH.sub.3                                                                          N                                        L-11                                                                             CH.sub.3                                                                           H  H  6-CH.sub.3                                                                          H  0 H  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                       L-11                                                                             CH.sub.3                                                                           H  H  5-CF.sub.3                                                                          H  0 H  OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                       L-11                                                                             CH.sub.3                                                                           H  H  6-OCF.sub.2 H                                                                       H  0 H  Cl  OCH.sub.3                                                                          CH                                       L-11                                                                             CH.sub.3                                                                           H  H  5-OCH.sub.3                                                                         H  0 H  CH.sub.3                                                                          OCH.sub.3                                                                          N                                        L-11                                                                             H    Cl Cl H     H  1 H  OCH.sub.3                                                                         OCH.sub.3                                                                          N                                        L-11                                                                             CH.sub.3                                                                           Cl Cl H     H  1 H  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                       L-11                                                                             CH.sub.3                                                                           Cl Cl H     H  1 H  OCH.sub.3                                                                         N(CH.sub.3).sub.2                                                                  N                                        L-11                                                                             CH.sub.3                                                                           Cl Cl H     H  0 H  OCH.sub.3                                                                         OCF.sub.2 H                                                                        CH                                       L-11                                                                             CH.sub. 3                                                                          Cl Cl H     H  0 H  CH.sub.3                                                                          CF.sub.3                                                                           CH                                       __________________________________________________________________________

                                      TABLE 28C                                   __________________________________________________________________________    General Structure 28                                                                                                 m.p.                                   L  R.sub.1                                                                            R.sub.12  R.sub.3                                                                             R  X   Y    Z  (°C.)                           __________________________________________________________________________    L-12                                                                             H    CH.sub.3  OCH.sub.2 CF.sub.3                                                                  H  Cl  OCH.sub.3                                                                          CH                                        L-12                                                                             H    CH.sub.2 CH.sub.3                                                                       CH.sub.2 OCH.sub.3                                                                  H  OCH.sub.3                                                                         OCH.sub.3                                                                          N                                         L-12                                                                             CH.sub.3                                                                           CH.sub.3  CH.sub.2 SCH.sub.3                                                                  H  CH.sub.3                                                                          CH.sub.3                                                                           CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Br                                                  H     H  OCH.sub.3                                                                         OCH.sub.3                                                                          N                                         L-12                                                                             H    CH.sub.2 OC.sub.2 H.sub.5                                                               H     H  CH.sub.3                                                                          CH.sub.3                                                                           CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.2 CF.sub.3                                                                       H     H  OCH.sub.3                                                                         CH.sub.3                                                                           N                                         L-12                                                                             CH.sub.3                                                                           CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                           H     H  Cl  OCH.sub.3                                                                          CH                                        L-12                                                                             H    COC.sub.2 H.sub.5                                                                       H     H  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                        L-12                                                                             H    CO.sub.2 C.sub.2 H.sub.5                                                                H     H  OCH.sub.3                                                                         OCH.sub.3                                                                          N                                         L-12                                                                             H    CH.sub.3  H     H  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                        L-12                                                                             H    CH.sub.3  H     CH.sub.3                                                                         OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.3  H     H  Cl  OCH.sub.3                                                                          CH                                        L-12                                                                             CH.sub.2 CF.sub.3                                                                  CH.sub.3  H     H  CH.sub.3                                                                          OCH.sub.3                                                                          N                                         L-12                                                                             CH.sub.2 CH.sub.3                                                                  CH.sub.3  H     H  OCH.sub.3                                                                         OCH.sub.3                                                                          N                                         L-12                                                                             CF.sub.2 H                                                                         CH.sub.3  H     H  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                        L-12                                                                             OCH.sub.3                                                                          CH.sub.3  H     H  OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                        L-12                                                                             SO.sub.2 CH.sub.3                                                                  CH.sub.3  H     H  Cl  OCH.sub.3                                                                          CH                                        L-12                                                                             CH.sub.3                                                                           H         H     H  CH.sub.3                                                                          OCH.sub.3                                                                          N                                         L-12                                                                             CH.sub.3                                                                           CH.sub.2 CH.sub.3                                                                       H     H  OCH.sub.3                                                                         OCH.sub.3                                                                          N                                         L-12                                                                             CH.sub.3                                                                           (CH.sub.2).sub.5 CH.sub.3                                                               H     H  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.3  5-F   H  OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.3  6-Cl  H  Cl  OCH.sub.3                                                                          CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.3  5-Br  H  CH.sub.3                                                                          OCH.sub.3                                                                          N                                         L-12                                                                             CH.sub.3                                                                           CH.sub.3  6-CF.sub.3                                                                          H  OCH.sub.3                                                                         OCH.sub.3                                                                          N                                         L-12                                                                             CH.sub.3                                                                           CH.sub.3  5-CH.sub.3                                                                          H  CH.sub.3                                                                          OCH.sub.3                                                                          CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.3  6-OCH.sub.3                                                                         H  OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.3  5-OCF.sub.2 H                                                                       H  Cl  OCH.sub.3                                                                          CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.3  6-OC.sub.2 H.sub.5                                                                  H  CH.sub.3                                                                          OCH.sub.3                                                                          N                                         L-12                                                                             H    CH.sub.3  H     H  OCH.sub.3                                                                         N(CH.sub.3).sub.2                                                                  N                                         L-12                                                                             CH.sub.3                                                                           CH.sub.3  H     H  CH.sub.3                                                                          CH.sub.3                                                                           CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.3  H     H  OCH.sub.3                                                                         OCF.sub.2 H                                                                        CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.2 CH.sub.2 Cl                                                                    H     H  OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.2 CH.sub.2 Cl                                                                    H     H  OCH.sub.3                                                                         CH.sub.3                                                                           N                                         L-12                                                                             CH.sub.3                                                                           CH.sub.2 CH.sub.2 F                                                                     H     H  OCH.sub.3                                                                         CH.sub.3                                                                           N                                         L-12                                                                             CH.sub.3                                                                           CH.sub.2 CH.sub.2 F                                                                     H     H  OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.2 CF.sub.3                                                                       H     H  OCH.sub.3                                                                         OCH.sub.3                                                                          CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.2 CF.sub.3                                                                       H     H  OCH.sub.3                                                                         CH.sub.3                                                                           N                                         L-12                                                                             CH.sub.3                                                                           CH.sub.2 CH.sub.2 Br                                                                    H     H  OCH.sub.3                                                                         CH.sub.3                                                                           N                                         L-12                                                                             CH.sub.3                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                             H     H  OCH.sub.3                                                                         CH.sub.3                                                                           N                                         L-12                                                                             CH.sub.3                                                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                             H     H  OCH.sub.3                                                                         CH.sub.3                                                                           CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      H     H  OCH.sub.3                                                                         CH.sub.3                                                                           CH                                        L-12                                                                             CH.sub.3                                                                           CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      H     H  OCH.sub.3                                                                         CH.sub.3                                                                           N                                         L-12                                                                             CH.sub.3                                                                           (CH.sub.2).sub.3 CH.sub.2 OCH.sub.3                                                     H     H  OCH.sub.3                                                                         CH.sub.3                                                                           N                                         L-12                                                                             CH.sub.3                                                                           (CH.sub.2).sub.3 CH.sub.2 Cl                                                            H     H  OCH.sub.3                                                                         CH.sub.3                                                                           CH                                        __________________________________________________________________________

                                      TABLE 29                                    __________________________________________________________________________    General Structure 29                                                                                                          m.p.                          L  R.sub.1   R.sub.13                                                                            R.sub.3 R.sub.14                                                                         R  X    Y      Z  (°C.)                  __________________________________________________________________________    L-13                                                                             H         H     H       -- H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                               L-13                                                                             CH.sub.3  H     H       -- H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                               L-13                                                                             CH.sub.2 CH.sub.3                                                                       H     H       -- H  Cl   OCH.sub.3                                                                            CH                               L-13                                                                             (CH.sub.2).sub.2 CH.sub.3                                                               H     H       -- H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                L-13                                                                             CF.sub.2 H                                                                              H     H       -- H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                L-13                                                                             CH.sub.2 CF.sub.3                                                                       H     H       -- H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                               L-13                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                             H     H       -- H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                               L-13                                                                             CH.sub.2 CH.sub.2 OH                                                                    H     H       -- H  Cl   OCH.sub.3                                                                            CH                               L-13                                                                             CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   H     H       -- H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                L-13                                                                             OH        H     H       -- H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                L-13                                                                             OSi(CH.sub.3).sub.3                                                                     H     H       -- H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                               L-13                                                                             OCH.sub.3 H     H       -- H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                               L-13                                                                             OCH.sub.2 CH.sub.3                                                                      H     H       -- H  Cl   OCH.sub.3                                                                            CH                               L-13                                                                             SO.sub.2 CH.sub.3                                                                       H     H       -- H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                L-13                                                                             C.sub.6 H.sub.5                                                                         H     H       -- H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                L-13                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                H     H       -- H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                               L-13                                                                             CH.sub.3  H     H       -- CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                            CH                               L-13                                                                             CH.sub.3  CH.sub.3                                                                            H       -- H  Cl   OCH.sub.3                                                                            CH                               L-13                                                                             CH.sub.3  CH.sub.2 CH.sub.3                                                                   H       -- H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                L-13                                                                             CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                           H       -- H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                L-13                                                                             CH.sub.3  H     5-F     -- H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                               L-13                                                                             CH.sub.3  H     6-Cl    -- H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                               L-13                                                                             CH.sub.3  H     5-Br    -- H  Cl   OCH.sub.3                                                                            CH                               L-13                                                                             CH.sub.3  H     6-CF.sub.3                                                                            -- H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                L-13                                                                             CH.sub.3  H     5-CH.sub.3                                                                            -- H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                L-13                                                                             CH.sub.3  H     6-OCH.sub.3                                                                           -- H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                               L-13                                                                             CH.sub.3  H     5-OCF.sub.2 H                                                                         -- H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                               L-13                                                                             CH.sub.3  H     6-OC.sub.2 H.sub.5                                                                    -- H  Cl   OCH.sub.3                                                                            CH                               L-13                                                                             CH.sub.3  H     H       -- H  CH.sub.3                                                                           CH.sub.3                                                                             CH                               L-13                                                                             CH.sub.3  H     H       -- H  CH.sub.3                                                                           CF.sub.3                                                                             CH                               L-13                                                                             CH.sub.3  H     H       -- H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                    N                                L-13                                                                             CH.sub.3  H     H       -- H  OCH.sub.3                                                                          OCF.sub.2 H                                                                          CH                               L-14                                                                             H         H     H       -- H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                               L-14                                                                             CH.sub.3  H     H       -- H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                               L-14                                                                             CH.sub.2 CH.sub.3                                                                       H     H       -- H  Cl   OCH.sub.3                                                                            CH                               L-14                                                                             (CH.sub.2).sub.2 CH.sub.3                                                               H     H       -- H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                L-14                                                                             CF.sub.2 H                                                                              H     H       -- H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                L-14                                                                             CH.sub.2 CF.sub.3                                                                       H     H       -- H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                               L-14                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                             H     H       -- H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                               L-14                                                                             CH.sub.2 CH.sub.2 OH                                                                    H     H       -- H  Cl   OCH.sub.3                                                                            CH                               L-14                                                                             CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   H     H       -- H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                L-14                                                                             OH        H     H       -- H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                L-14                                                                             OSi(CH.sub.3).sub.3                                                                     H     H       -- H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                               L-14                                                                             OCH.sub.3 H     H       -- H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                               L-14                                                                             OCH.sub.2 CH.sub.3                                                                      H     H       -- H  Cl   OCH.sub.3                                                                            CH                               L-14                                                                             SO.sub.2 CH.sub.3                                                                       H     H       -- H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                L-14                                                                             C.sub.6 H.sub.5                                                                         H     H       -- H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                L-14                                                                             CH.sub.2 C.sub.6 H.sub.5                                                                H     H       -- H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                               L-14                                                                             CH.sub.3  H     H       -- CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                            CH                               L-14                                                                             CH.sub.3  CH.sub.3                                                                            H       -- H  Cl   OCH.sub.3                                                                            CH                               L-14                                                                             CH.sub.3  CH.sub.2 CH.sub.3                                                                   H       -- H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                L-14                                                                             CH.sub.3  (CH.sub.2 ).sub.2 CH.sub.3                                                          H       -- H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                L-14                                                                             CH.sub.3  H     5-F     -- H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                               L-14                                                                             CH.sub.3  H     6-Cl    -- H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                               L-14                                                                             CH.sub.3  H     5-Br    -- H  Cl   OCH.sub.3                                                                            CH                               L-14                                                                             CH.sub.3  H     6-CF.sub.3                                                                            -- H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                L-14                                                                             CH.sub.3  H     5-CH.sub.3                                                                            -- H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                L-14                                                                             CH.sub.3  H     6-OCH.sub.3                                                                           -- H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                               L-14                                                                             CH.sub.3  H     5-OCF.sub.2 H                                                                         -- H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                               L-14                                                                             CH.sub.3  H     6-OC.sub.2 H.sub.5                                                                    -- H  Cl   OCH.sub.3                                                                            CH                               L-14                                                                             CH.sub.3  H     H       -- H  CH.sub.3                                                                           CH.sub.3                                                                             CH                               L-14                                                                             CH.sub.3  H     H       -- H  CH.sub.3                                                                           CF.sub.3                                                                             CH                               L-14                                                                             CH.sub.3  H     H       -- H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                    N                                L-14                                                                             CH.sub.3  H     H       -- H  OCH.sub.3                                                                          OCF.sub.2 H                                                                          CH                               L-15                                                                             H         CH.sub.3                                                                            H       H  H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                               L-15                                                                             CH.sub.3  CH.sub.3                                                                            H       H  H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                               L-15                                                                             CH.sub.2 CH.sub.3                                                                       CH.sub.3                                                                            H       H  H  Cl   OCH.sub.3                                                                            CH                               L-15                                                                             (CH.sub.2).sub.2 CH.sub.3                                                               CH.sub.3                                                                            H       H  H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                L-15                                                                             CF.sub.2 H                                                                              CH.sub.3                                                                            H       H  H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                L-15                                                                             CH.sub.2 CF.sub.3                                                                       CH.sub.3                                                                            H       H  H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                               L-15                                                                             CH.sub.2 CH.sub.2 OCH.sub.3                                                             CH.sub.3                                                                            H       H  H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                               L-15                                                                             CH.sub.2 CH.sub.2 OH                                                                    CH.sub.3                                                                            H       H  H  Cl   OCH.sub.3                                                                            CH                               L-15                                                                             CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   CH.sub.3                                                                            H       H  H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                L-15                                                                             OH        CH.sub.3                                                                            H       H  H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                L-15                                                                             OSi(CH.sub.3).sub.3                                                                     CH.sub.3                                                                            H       H  H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                               L-15                                                                             OCH.sub.3 CH.sub.3                                                                            H       H  H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                               L-15                                                                             OCH.sub.2 CH.sub.3                                                                      CH.sub.3                                                                            H       H  H  Cl   OCH.sub.3                                                                            CH                               L-15                                                                             SO.sub.2 CH.sub.3                                                                       CH.sub.3                                                                            H       H  H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                L-15                                                                             C.sub.6 H.sub.5                                                                         CH.sub.3                                                                            H       H  H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                L-15                                                                             CH.sub. 2 C.sub.6 H.sub.5                                                               CH.sub.3                                                                            H       H  H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                               L-15                                                                             H         CH.sub.3                                                                            H       H  CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                            CH                               L-15                                                                             CH.sub.3  CH.sub.3                                                                            H       H  CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                                                            N                                L-15                                                                             CH.sub.3  CH.sub.3                                                                            H       H  H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                L-15                                                                             CH.sub.3  CH.sub.3                                                                            H       CH.sub.3                                                                         H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                               L-15                                                                             CH.sub.3  CH.sub.2 CH.sub.3                                                                   H       H  H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                               L-15                                                                             CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                           H       H  H  Cl   OCH.sub.3                                                                            CH                               L-15                                                                             CH.sub.3  CH.sub.3                                                                            6-F     H  H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                L-15                                                                             CH.sub.3  CH.sub.3                                                                            5-Cl    H  H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                L-15                                                                             CH.sub.3  CH.sub.3                                                                            6-Br    H  H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                               L-15                                                                             CH.sub.3  CH.sub.3                                                                            5-CF.sub.3                                                                            H  H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                               L-15                                                                             CH.sub.3  CH.sub.3                                                                            6-CH.sub.3                                                                            H  H  Cl   OCH.sub.3                                                                            CH                               L-15                                                                             CH.sub.3  CH.sub.3                                                                            5-OCH.sub.3                                                                           H  H  CH.sub.3                                                                           OCH.sub.3                                                                            N                                L-15                                                                             CH.sub.3  CH.sub.3                                                                            6-OCF.sub.2 H                                                                         H  H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                L-15                                                                             CH.sub.3  CH.sub.3                                                                            5-OC.sub.2 H.sub.5                                                                    H  H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                               L-15                                                                             H         CH.sub.3                                                                            6-Cl    H  H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                               L-15                                                                             CH.sub.3  CH.sub.3                                                                            H       H  H  CH.sub.3                                                                           CH.sub.3                                                                             CH                               L-15                                                                             CH.sub.3  CH.sub.3                                                                            H       H  H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                    N                                L-15                                                                             CH.sub.3  CH.sub.3                                                                            H       H  H  OCF.sub.2 H                                                                        OCF.sub.2 H                                                                          CH                               L-13                                                                             H         H     5-C.sub.2 H.sub.5                                                                     -- H  CH.sub.3                                                                           CH.sub.3                                                                             CH                               L-13                                                                             CH.sub.3  CH.sub.3                                                                            6-OCH.sub.2 CF.sub.3                                                                  -- H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                L-13                                                                             CH.sub.3  CH.sub.3                                                                            6-SCH.sub.3                                                                           -- H  Cl   OCH.sub.3                                                                            CH                               L-13                                                                             H         H     5-CH.sub.2 OCH.sub.3                                                                  -- H  OCH.sub.3                                                                          C.tbd.CH                                                                             CH                               L-13                                                                             H         H     5-CH.sub.2 SCH.sub.3                                                                  -- H  OCH.sub.3                                                                          CH.sub.2 S(O)CH.sub.3                                                                N                                L-14                                                                             H         H     5-C.sub.2 H.sub.5                                                                     -- H  CH.sub.3                                                                           CH.sub.3                                                                             CH                               L-14                                                                             CH.sub.3  CH.sub.3                                                                            5-OCH.sub.2 CHF.sub.2                                                                 -- H  OCH.sub.3                                                                          OCH.sub.3                                                                            CH                               L-14                                                                             H         H     6-CH.sub.2 SCH.sub.3                                                                  -- H  CH.sub.3                                                                           OCH.sub.3                                                                            CH                               L-15                                                                             CH.sub.3  CH.sub.3                                                                            5-SC.sub.2 H.sub.5                                                                    H  H  CH.sub.3                                                                           CH.sub.3                                                                             CH                               L-15                                                                             H         CH.sub.3                                                                            6-OCH.sub.2 CH.sub.2 F                                                                H  H  OCH.sub.3                                                                          OCH.sub.3                                                                            N                                L-15                                                                             H         CH.sub.3                                                                            5-CH.sub.2 OCH.sub.3                                                                  H  H  OCH.sub.3                                                                          CH.sub.2 SO.sub.2 CH.sub.3                                                           N                                __________________________________________________________________________

                                      TABLE 30                                    __________________________________________________________________________    General Structure 30                                                                                                          m.p.                          BP                                                                              R.sub.1   R.sub.16     R.sub.15                                                                            R  X    Y     Z  (°C.)                  __________________________________________________________________________    5 H         4-Cl         CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                               5 CH.sub.3  4-Cl         CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                               5 CH.sub.2 CH.sub.3                                                                       4-Cl         CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                           CH                               5 (CH.sub.2).sub.2 CH.sub.3                                                               4-Cl         CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                5 CF.sub.2 H                                                                              4-Cl         CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                5 CH.sub.2 CF.sub.3                                                                       4-Cl         CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                               5 CH.sub.2 CH.sub.2 OCH.sub.3                                                             4-Cl         CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                               5 CH.sub.2 CH.sub.2 OH                                                                    4-Cl         CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                           CH                               5 CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                   4-Cl         CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                5 OH        4-Cl         CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                5 OSi(CH.sub.3).sub.3                                                                     4-Cl         CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub. 3                                                                          CH                               5 OCH.sub.3 4-Cl         CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                               5 OCH.sub.2 CH.sub.3                                                                      4-Cl         CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                           CH                               5 SO.sub.2 CH.sub.3                                                                       4-Cl         CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                5 C.sub.6 H.sub.5                                                                         4-Cl         CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                5 CH.sub.2 C.sub.6 H.sub.5                                                                4-Cl         CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                               5 H         4-Cl         CH.sub.3                                                                            CH.sub.3                                                                         OCH.sub.3                                                                          OCH.sub.3                                                                           CH                               5 CH.sub.3  H            CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                           CH                               5 CH.sub.3  4-Cl         H     H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                5 CH.sub.3  4-Cl         CH.sub.2 CH.sub.3                                                                   H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                5 CH.sub.3  4-Cl         (CH.sub.2).sub.2 CH.sub.3                                                           H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                               5 CH.sub.3  4-CH.sub.3   CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                           CH                               5 CH.sub.3  4-CH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                               5 CH.sub.3  4-(CH.sub.2).sub.2 CH.sub.3                                                                CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                5 CH.sub.3  4-F          CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                5 CH.sub.3  4-Br         CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                               5 CH.sub.3  4-NO.sub.2   CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                               5 CH.sub.3  4-CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                           CH                               5 CH.sub.3  4-SO.sub.2 N(CH.sub.3).sub.2                                                               CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                5 CH.sub.3  4-SO.sub.2 N(CH.sub.3)(CH.sub.2).sub.2 CH.sub.3                                            CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                5 CH.sub.3  4-SO.sub.2 N(OCH.sub.3)CH.sub.3                                                            CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                               5 CH.sub.3  4-SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                               5 CH.sub.3  4-SO.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                           CH                               5 CH.sub.3  4-SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                       CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                5 CH.sub.3  4-SO.sub.2 CH.sub.2 CH═CH.sub.2                                                        CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                5 CH.sub.3  4-OCF.sub.2 H                                                                              CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                               4 H         3-Cl         CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                               4 CH.sub.3  3-CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                           CH                               4 CH.sub.3  3-CO.sub.2 CH.sub.2 CH.sub. 3                                                              CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                4 CH.sub.3  3-CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                       CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                4 CH.sub.3  3-CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                       CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                               4 CH.sub.3  3-CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                     CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                               4 CH.sub.3  3-CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                            CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                           CH                               4 CH.sub.3  3-CO.sub.2 CH.sub.2 CH═CH.sub.2                                                        CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                4 CH.sub.3  3-NO.sub.2   CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                4 CH.sub.3  5-Br         CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                               4 CH.sub.3  5-CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                               3 H         4-CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                           CH                               3 CH.sub.3  4-CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                3 CH.sub.3  4-Cl         CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                3 CH.sub.3  4-SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                               3 CH.sub.3  4-NO.sub. 2  CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                               3 CH.sub.3  4-F          CH.sub.3                                                                            H  OCF.sub.2 H                                                                        OCF.sub.2 H                                                                         CH                               4 CH.sub.3  3-F          CH.sub.3                                                                            H  CH.sub.3                                                                           CF.sub.3                                                                            CH                               5 CH.sub.3  4-Cl         CH.sub.3                                                                            H  CH.sub.3                                                                           CH.sub.3                                                                            CH                               5 CH.sub.3  4-Br         CH.sub.3                                                                            H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                   N                                5 CH.sub.3  4-Cl         CH.sub.3                                                                            H  OCH.sub.3                                                                          OCH.sub.2 CF.sub.3                                                                  N                                5 CH.sub.3  4-Cl         CH.sub.3                                                                            H  OCH.sub.3                                                                          OCF.sub.2 H                                                                         CH                               __________________________________________________________________________     BP = Bridge Position                                                     

                                      TABLE 31                                    __________________________________________________________________________    General Structure 31                                                                                             m.p.                                       R.sub.1    R.sub.15                                                                            R   X   Y      Z  (°C.)                               __________________________________________________________________________    H          CH.sub.3                                                                            H   CH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CH.sub.3   CH.sub.3                                                                            H   OCH.sub.3                                                                         OCH.sub.3                                                                            CH                                            CH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                            H   Cl  OCH.sub.3                                                                            CH                                            (CH.sub.2).sub.2 CH.sub.3                                                                CH.sub.3                                                                            H   CH.sub.3                                                                          OCH.sub.3                                                                            N                                             CF.sub.2 H CH.sub.3                                                                            H   OCH.sub.3                                                                         OCH.sub.3                                                                            N                                             CH.sub.2 CF.sub.3                                                                        CH.sub.3                                                                            H   CH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CH.sub.2 CH.sub.2 OCH.sub.3                                                              CH.sub.3                                                                            H   OCH.sub.3                                                                         OCH.sub.3                                                                            CH                                            CH.sub.2 CH.sub.2 OH                                                                     CH.sub.3                                                                            H   CH.sub.3                                                                          OCH.sub.3                                                                            N                                             CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    CH.sub.3                                                                            H   OCH.sub.3                                                                         OCH.sub.3                                                                            N                                             OH         CH.sub.3                                                                            H   CH.sub.3                                                                          OCH.sub.3                                                                            CH                                            OSi(CH.sub.3).sub.3                                                                      CH.sub.3                                                                            H   Cl  OCH.sub.3                                                                            CH                                            OCH.sub.3  CH.sub.3                                                                            H   CH.sub.3                                                                          OCH.sub.3                                                                            N                                             OCH.sub.2 CH.sub.3                                                                       CH.sub.3                                                                            H   OCH.sub.3                                                                         OCH.sub.3                                                                            N                                             SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                            H   CH.sub.3                                                                          OCH.sub.3                                                                            CH                                            C.sub.6 H.sub.5                                                                          CH.sub.3                                                                            H   OCH.sub.3                                                                         OCH.sub.3                                                                            CH                                            CH.sub.2 C.sub.6 H.sub.5                                                                 CH.sub.3                                                                            H   CH.sub.3                                                                          OCH.sub.3                                                                            N                                             H          CH.sub.3                                                                            CH.sub.3                                                                          OCH.sub.3                                                                         OCH.sub.3                                                                            N                                             CH.sub.3   CH.sub.3                                                                            CH.sub.3                                                                          CH.sub.3                                                                          OCH.sub.3                                                                            CH                                            CH.sub.3   CH.sub.2 CH.sub.3                                                                   H   OCH.sub.3                                                                         OCH.sub.3                                                                            CH                                            CH.sub.3   (CH.sub.2).sub.2 CH.sub.3                                                           H   CH.sub.3                                                                          OCH.sub.3                                                                            N                                             H          CH.sub.3                                                                            H   CH.sub.3                                                                          CH.sub.3                                                                             CH                                            CH.sub.3   H     H   Cl  OCH.sub.3                                                                            CH                                            CH.sub.3   CH.sub.3                                                                            H   OCH.sub.3                                                                         N(CH.sub.3).sub.2                                                                    N                                             CH.sub.3   CH.sub.3                                                                            H   OCH.sub.3                                                                         OCH.sub.2 CF.sub.3                                                                   CH                                            CH.sub.3   CH.sub.3                                                                            H   OCH.sub.3                                                                         OCF.sub.2 H                                                                          CH                                            __________________________________________________________________________

                                      TABLE 32                                    __________________________________________________________________________    General Structure 32                                                                                               m.p.                                     R.sub.1                                                                             R.sub.2 R.sub.3                                                                            A  R  X.sub.1,2,3 or 4                                                                    Y.sub.1,2,3 or 4                                                                    (°C.)                             __________________________________________________________________________    H     SO.sub.2 CH.sub.3                                                                     H    A-2                                                                              H  CH.sub.3                                                                            O                                              CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                     H    A-2                                                                              H  CH.sub.3                                                                            O                                              CH.sub.2 CH.sub.3                                                                   SO.sub.2 N(CH.sub.3).sub.2                                                            H    A-2                                                                              H  CH.sub.3                                                                            O                                              CH.sub.2 CF.sub.3                                                                   NO.sub.2                                                                              H    A-2                                                                              H  CH.sub.3                                                                            O                                              CF.sub.2 H                                                                          SO.sub.2 CH.sub.3                                                                     H    A-2                                                                              H  CH.sub.3                                                                            O                                              H     SO.sub.2 N(CH.sub.3).sub.2                                                            H    A-2                                                                              H  OCH.sub.3                                                                           CH.sub.2                                       CH.sub.3                                                                            OSO.sub.2 CH.sub.3                                                                    H    A-2                                                                              H  OCH.sub.3                                                                           CH.sub.2                                       H     CO.sub.2 CH.sub.2 CH.sub.3                                                            H    A-2                                                                              H  H     O                                              CH.sub.3                                                                            NO.sub.2                                                                              H    A-2                                                                              H  H     O                                              H     SO.sub.2 N(CH.sub.3).sub.2                                                            H    A-2                                                                              H  OCH.sub.3                                                                           O                                              CH.sub.3                                                                            OSO.sub.2 CH.sub.3                                                                    H    A-2                                                                              H  OCH.sub.3                                                                           O                                              CH.sub.3                                                                            SO.sub.2 CH.sub.3                                                                     5-OCH.sub.3                                                                        A-2                                                                              H  OCH.sub. 3                                                                          O                                              H     NO.sub.2                                                                              H    A-2                                                                              CH.sub.3                                                                         CH.sub.3                                                                            O                                              H     SO.sub.2 CH.sub.3                                                                     H    A-3                                                                              H  CH.sub.3                                                                            --                                             CH.sub.3                                                                            SO.sub.2 N(CH.sub.3).sub.2                                                            H    A-3                                                                              H  CH.sub.3                                                                            --                                             CH.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.3                                                                     H    A-3                                                                              H  CH.sub.3                                                                            --                                             CH.sub.2 CF.sub.3                                                                   SO.sub.2 CH.sub.3                                                                     H    A-3                                                                              H  CH.sub.3                                                                            --                                             CF.sub.2 H                                                                          OSO.sub.2 CH.sub.3                                                                    H    A-3                                                                              H  CH.sub.3                                                                            --                                             H     SO.sub.2 N(CH.sub.3).sub.2                                                            H    A-3                                                                              H  H     --                                             CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                     H    A-3                                                                              H  H     --                                             H     SO.sub.2 CH.sub.3                                                                     H    A-3                                                                              H  OCH.sub.3                                                                           --                                             CH.sub.3                                                                            SO.sub.2 N(CH.sub.3).sub.2                                                            H    A-3                                                                              H  OCH.sub.3                                                                           --                                             CH.sub.2 CF.sub.3                                                                   OSO.sub.2 CH.sub.3                                                                    H    A-3                                                                              H  OCH.sub.3                                                                           --                                             CF.sub.2 H                                                                          CO.sub.2 CH.sub.3                                                                     H    A-3                                                                              H  OCH.sub.3                                                                           --                                             SO.sub.2 CH.sub.3                                                                   SO.sub.2 N(CH.sub.3).sub.2                                                            H    A-3                                                                              H  OCH.sub.3                                                                           --                                             H     OSO.sub.2 CH.sub.3                                                                    H    A-4                                                                              H  CH.sub.3                                                                            CH.sub.3                                       CH.sub.3                                                                            SO.sub.2 CH.sub.3                                                                     H    A-4                                                                              H  CH.sub.3                                                                            CH.sub.3                                       CH.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.3                                                                     H    A-4                                                                              H  CH.sub.3                                                                            CH.sub.3                                       CH.sub.2 CF.sub.3                                                                   NO.sub.2                                                                              H    A-4                                                                              H  CH.sub.3                                                                            CH.sub.3                                       CF.sub.2 H                                                                          SO.sub.2 CH.sub.3                                                                     H    A-4                                                                              H  CH.sub.3                                                                            CH.sub.3                                       H     SO.sub.2 N(CH.sub.3).sub.2                                                            H    A-4                                                                              H  OCH.sub.3                                                                           CH.sub.3                                       CH.sub.3                                                                            SO.sub.2 CH.sub.3                                                                     H    A-4                                                                              H  OCH.sub.3                                                                           CH.sub.3                                       H     NO.sub.2                                                                              H    A-4                                                                              H  H     CH.sub.3                                       CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                     H    A-4                                                                              H  H     CH.sub.3                                       H     SO.sub.2 N(CH.sub.3).sub.2                                                            H    A-4                                                                              H  CH.sub.3                                                                            H                                              CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                     H    A-4                                                                              H  CH.sub.3                                                                            H                                              H     SO.sub.2 CH.sub.3                                                                     H    A-4                                                                              H  OCH.sub.3                                                                           H                                              CH.sub.3                                                                            OSO.sub.2 CH.sub.3                                                                    H    A-4                                                                              H  OCH.sub.3                                                                           H                                              H     CO.sub.2 CH.sub.3                                                                     H    A-4                                                                              H  H     H                                              CH.sub.3                                                                            SO.sub.2 N(CH.sub.3).sub.2                                                            H    A-4                                                                              H  H     H                                              H     SO.sub.2 CH.sub.3                                                                     H    A-5                                                                              H  CH.sub.3                                                                            OCH.sub.3                                      CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                     H    A-5                                                                              H  C.sub.2 H.sub.5                                                                     SCH.sub.3                                      C.sub.2 H.sub.5                                                                     SO.sub.2 N(CH.sub.3).sub.2                                                            H    A-5                                                                              H  CH.sub.2 CF.sub.3                                                                   OCF.sub.2 H                                    H     SO.sub.2 CH.sub.3                                                                     H    A-6                                                                              H  CH.sub.3                                                                            --                                             CH.sub.3                                                                            NO.sub.2                                                                              H    A-6                                                                              H  OCH.sub.3                                                                           --                                             CF.sub.2 H                                                                          CO.sub.2 CH.sub.3                                                                     H    A-6                                                                              H  CH.sub.3                                                                            --                                             H     SO.sub.2 N(CH.sub.3).sub.2                                                            H    A-7                                                                              H  OCH.sub.3                                                                           OCH.sub.3                                      CH.sub.3                                                                            NO.sub.2                                                                              H    A-7                                                                              H  Cl    OCH.sub.3                                      C.sub.2 H.sub.5                                                                     Cl      H    A-7                                                                              H  CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                       CH.sub.2 CF.sub.3                                                                   CO.sub.2 CH.sub.3                                                                     H    A-7                                                                              H  CH.sub.3                                                                            Cl                                             __________________________________________________________________________

FORMULATIONS

Useful formulations of the compounds of Formula I can be prepared inconventional ways. They include dusts, granules, pellets, solutions,suspensions, emulsions, wettable powders, emulsifiable concentrates andthe like. Many of these can be applied directly. Sprayable formulationscan be extended in suitable media and used at spray volumes of from afew liters to several hundred liters per hectare. High strengthcompositions are primarily used as intermediates for furtherformulation. The formulations, broadly, contain about 1% to 99% byweight of active ingredient(s) and at least one of (a) about 0.1% to 20%surfactant(s) and (b) about 5% to 99% solid or liquid diluent(s). Morespecifically, they will contain these ingredients in the followingapproximate proportions:

    ______________________________________                                                    Weight Percent*                                                               Active                                                                        Ingredient                                                                            Diluent(s)                                                                              Surfactant(s)                                   ______________________________________                                        Wettable Powders                                                                            20-90      0-74     1-10                                        Oil Suspensions,                                                                             5-50     40-95     0-15                                        Emulsions, Solutions,                                                         (including Emulsifiable                                                       Concentrates)                                                                 Aqueous Suspension                                                                          10-50     40-84     1-20                                        Dusts          1-25     70-99     0-5                                         Granules and Pellets                                                                         1-95      5-99     0-15                                        High Strength 90-99      0-10     0-2                                         Compositions                                                                  ______________________________________                                    

Lower or higher levels of active ingredient can, of course, be presentdepending on the intended use and the physical properties of thecompound. Higher ratios of surfactant to active ingredient are sometimesdesirable, and are achieved by incorporation into the formulation or bytank mixing.

Typical solid diluents are described in Watkins, et al., "Handbook ofInsecticide Dust Diluents and Carriers", 2nd Ed., Dorland Books,Caldwell, N.J., but other solids, either mined or manufactured, may beused. The more absorptive diluents are preferred for wettable powdersand the denser ones for dusts. Typical liquid diluents and solvents aredescribed in Marsden, "Solvents Guide," 2nd Ed., Interscience, New York,1950. Solubility under 0.1% is preferred for suspension concentrates;solution concentrates are preferably stable against phase separation at0° C. "McCutcheon's Detergents and Emulsifiers Annual", MC PublishingCorp., Ridgewood, N.J., as well as Sisely and Wood, "Encyclopedia ofSurface Active Agents", Chemical Publishing Co., Inc., New York, 1964,list surfactants and recommended uses. All formulations can containminor amounts of additives to reduce foam, caking, corrosion,microbiological growth, etc. Preferably, ingredients should be approvedby the U.S. Environmental Protection Agency for the use intended.

The methods of making such compositions are well known. Solutions areprepared by simply mixing the ingredients. Fine solid compositions aremade by blending and, usually, grinding as in a hammer or fluid energymill. Suspensions are prepared by wet milling (see, for example,Littler, U.S. Patent 3,060,084). Granules and pellets may be made byspraying the active material upon preformed granular carriers or byagglomeration techniques. See J. E. Browning, "Agglomeration", ChemicalEngineering, Dec. 4, 1967, pp. 147ff. and "Perry's Chemical Engineer'sHandbook", 5th Ed., McGraw-Hill, New York, 1973, pp. 8-59ff.

For further information regarding the art of formulation, see forexample:

H. M. Loux, U.S. Pat. No. 3,235,361, Feb. 15, 1966, Col. 6, line 16through Col. 7, line 19 and Examples 10 through 41;

R. W. Luckenbaugh, U.S. Pat. No. 3,309,192, Mar. 14, 1967, Col. 5, line43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58,132, 138-140, 162-164, 166, 167 and 169-182;

H. Gysin and E. Knusli, U.S. Pat. No. 2,891,855, June 23, 1959, Col. 3,line 66 through Col. 5, line 17 and Examples 1-4;

G. C. Klingman, "Weed Control as a Science", John Wiley and Sons, Inc.,New York, 1961, pp. 81-96; and

J. D. Fryer and S. A. Evans, "Weed Control Handbook", 5th Ed., BlackwellScientific Publications, Oxford, 1968, pp. 101-103.

In the following examples, all parts are by weight unless otherwiseindicated.

EXAMPLE 9 High Strength Concentrate

    ______________________________________                                        2-bromo-N--[(4,6-dimethoxypyrimidin-2-yl)aminocar-                                                       98.5%                                              bonyl]-N'--methylbenzenesulfonimidamide                                       silica aerogel             0.5%                                               synthetic amorphous fine silica                                                                          1.0%                                               ______________________________________                                    

The ingredients are blended and ground in a hammer-mill to produce ahigh strength concentrate essentially all passing a U.S.S. No. 50 screen(0.3 mm openings). This material may then be formulated in a variety ofways.

EXAMPLE 10 Aqueous Suspension

    ______________________________________                                        2-chloro-N--[(4,6-dimethoxypyrimidin-2-yl)aminocar-                                                      25%                                                bonyl]-N'--methylbenzenesulfonimidamide                                       hydrated attapulgite        3%                                                crude calcium ligninsulfonate                                                                            10%                                                sodium hydrogen phosphate  0.5%                                               water                      61.5%                                              ______________________________________                                    

The ingredients are ground together in a ball or roller mill until thesolid particles have been reduced to diameters under 10 microns.

EXAMPLE 11 Aqueous Suspension

    ______________________________________                                        2-bromo-N--[(4,6-dimethoxypyrimidin-2-yl)aminocar-                                                        50%                                               bonyl]-N'--methylbenzenesulfonimidamide                                       polyacrylic acid thickener 0.3%                                               dodecylphenol polyethylene glycol ether                                                                  0.5%                                               disodium phosphate         1.0%                                               monosodium phosphate       0.5%                                               polyvinyl alcohol          1.0%                                               pentachlorophenol          0.4%                                               water                      46.3%                                              ______________________________________                                    

The ingredients are ground together in a sand mill to produce particlesessentially all under 5 microns in size.

EXAMPLE 12 Wettable Powder

    ______________________________________                                        2-nitro-N--[(4,6-dimethoxypyrimidin-2-yl)aminocar-                                                        40%                                               bonyl]-N'--methylbenzenesulfonimidamide                                       dioctyl sodium sulfosuccinate                                                                            1.5%                                               sodium ligninsulfonate       3%                                               low viscosity methyl cellulose                                                                           1.5%                                               attapulgite                 54%                                               ______________________________________                                    

The ingredients are thoroughly blended, passed through an air mill, toproduce an average particle size under 15 microns, reblended, and siftedthrough a U.S.S. No. 50 sieve (0.3 mm openings) before packaging.

All compounds of the invention may be formulated in the same manner.

EXAMPLE 13 Oil Suspension

    ______________________________________                                        2-carbomethoxy-N--[(4,6-dimethoxypyrimidin-2-yl)amino-                                                      25%                                             carbonyl]-N'--methylbenzenesulfonimidamide                                    polyoxyethylene sorbitol hexaoleate                                                                          5%                                             highly aliphatic hydrocarbon oil                                                                            70%                                             ______________________________________                                    

The ingredients are ground together in a sand mill until the solidparticles have been reduced to under about 5 microns. The resultingthick suspension may be applied directly, but preferably after beingextended with oils or emulsified in water.

EXAMPLE 14 Wettable Powder

    ______________________________________                                        2-bromo-N--[(4,6-dimethoxypyrimidin-2-yl)aminocar-                                                       80%                                                bonyl]-N'--methylbenzenesulfonimidamide                                       sodium alkylnaphthalenesulfonate                                                                          2%                                                sodium ligninsulfonate      2%                                                synthetic amorphous silica  3%                                                kaolinite                  13%                                                ______________________________________                                    

The ingredients are blended and then hammer-milled to produce particlesof the active ingredient which are essentially less than 50 microns indiameter. The material is reblended before packaging.

EXAMPLE 15 Extruded Pellet

    ______________________________________                                        2-bromo-N--[(4,6-dimethoxypyrimidin-2-yl)aminocar-                                                       25%                                                bonyl]N'--methylbenzenesulfonimidamide                                        anhydrous sodium sulfate   10%                                                crude calcium ligninsulfonate                                                                             5%                                                sodium alkylnaphthalenesulfonate                                                                          1%                                                calcium/magnesium betonite 59%                                                ______________________________________                                    

The ingredients are blended, hammer-milled and then moistened with about12% water. The mixture is extruded as cylinders about 3 mm diameterwhich are cut to produce pellets about 3 mm long. These may be useddirectly after drying, or the dried pellets may be crushed to pass aU.S.S. No. 20 sieve (0.84 mm openings). The granules held on a U.S.S.No. 40 sieve (0.42 mm openings) may be packaged for use and the finesrecycled.

EXAMPLE 16 Wettable Powder

    ______________________________________                                        2-chloro-N--[(4,6-dimethoxypyrimidin-2-yl)aminocar-                                                      50%                                                bonyl]-N'--methylbenzenesulfonimidamide                                       sodium alkylnaphthalenesulfonate                                                                          2%                                                low viscosity methyl cellulose                                                                            2%                                                diatomaceous earth         46%                                                ______________________________________                                    

The ingredients are blended, coarsely hammer-milled and then air-milledto produce particles essentially all below 10 microns in diameter. Theproduct is reblended before packaging.

EXAMPLE 17 Granule

    ______________________________________                                        Wettable Powder of Example 14                                                                       15%                                                     gypsum                69%                                                     potassium sulfate     16%                                                     ______________________________________                                    

The ingredients are blended in a rotating mixer and water sprayed on toaccomplish granulation. When most of the material has reached thedesired range of 1.0 to 0.42 mm (U.S.S. #18 to 40 sieves), the granulesare removed, dried, and screened. Oversize material is crushed toproduce additional material in the desired range. These granules contain12% active ingredient.

EXAMPLE 18 Wettable Powder

    ______________________________________                                        2-bromo-N--[(4,6-dimethoxypyrimidin-2-yl)aminocar-                                                       65%                                                bonyl]-N'--methylbenzenesulfonimidamide                                       dodecylphenol polyethylene glycol ether                                                                   2%                                                sodium ligninsulfonate      4%                                                sodium silicoaluminate      6%                                                montmorillonite (calcined) 23%                                                ______________________________________                                    

The ingredients are thoroughly blended. The liquid surfactant is addedby spraying upon the solid ingrediets in the blender. After grinding ina hammer mill to produce particles essentially all below 100 microns,the material is reblended and sifted through a U.S.S. No. 50 sieve (0.3mm opening) and packaged.

UTILITY

Test results indicate that the compounds of the present invention arehighly active preemergent or postemergent herbicides or plant growthregulants. Many of them have utility for broad-spectrum pre- and/orpost-emergence weed control in areas where complete control of allvegetation is desired, such as around fuel storage tanks, ammunitiondepots, industrial storage areas, parking lots, drive-in theaters,around billboards, highway and railroad structures. Alternatively, thesubject compounds are useful to modify plant growth.

The rates of application for the compounds of the invention aredetermined by a number of factors, including their use as plant growthmodifiers or as herbicides, the types of weeds to be controlled, weatherand climate, formulations selected, mode of application, amount offoliage present, etc. In general terms, the subject compounds should beapplied at levels of around 0.10 to 10 kg of active ingredient perhectare, the lower rates being suggested for use on lighter soils and/orthose having a low organic matter content, for selective weed control orfor situations where only short-term persistence is required.

The compounds of the invention may be used in combination with any othercommercial herbicide; examples of which are those of the triazine,triazole, uracil, urea, amide, diphenylether, carbamate and bipyridyliumtypes.

The herbicidal properties of the subject compounds were discovered in anumber of greenhouse tests. The test procedures and results follow.##STR35##

TEST A

Seeds of crabgrass (Digitaria sp.), barnyardgrass (Echinochloacrusgalli), wild oats (Avena fatua), sicklepod (Cassia obtusifolia),morningglory (Ipomoea spp.), cocklebur (Xanthium pensylvanicum),sorghum, corn, soybean, sugarbeet, cotton, rice, wheat and purplenutsedge (Cyperus rotundus) tubers were planted and treatedpre-emergence with the test chemicals dissolved in a non-phytotoxicsolvent. The crop and weed species on which compounds 3 through 13 weretested did not include sicklepod but did include velvetleaf andcheatgrass. Delivery rates in kg/ha are as indicated.

At the same time, these crop and weed species were treatedpost-emergence with a soil/foliage application. At the time oftreatment, the plants ranged in height from 2 to 18 cm. Treated plantsand controls were maintained in a greenhouse for sixteen days, afterwhich all species were compared to controls and visually rated forresponse to treatment. The ratings, summarized in Table A, are based ona numerical scale extending from 0=no injury, to 10=complete kill. Theaccompanying descriptive symbols have the following meanings:

C=chlorosis/necrosis;

B=burn;

D=defoliation;

E=emergence inhibition;

G=growth retardation;

H=formative effects;

U=unusual pigmentation; and

X=axillary stimulation.

                                      TABLE A                                     __________________________________________________________________________            Compound 1                                                                           Compound 2                                                                           Compound 3                                                                             Compound 4                                                                            Compound 5                                                                            Compound                                                                              Compound 7             Rate kg/ha                                                                            0.4    0.4    0.4  0.05                                                                              0.4 0.05                                                                              0.4 0.05                                                                              0.4 0.05                                                                              0.4 0.05               __________________________________________________________________________    POST-EMERGENCE                                                                Morningglory                                                                          5C,9G  3C,8H  3C,8G                                                                              2C,7G                                                                             3C,5G                                                                             1C,2G                                                                             10C 3C,7G                                                                             5C,9G                                                                             3C,8G                                                                             5C,9G                                                                             2C,5G              Cocklebur                                                                             3H     4C,9H  3G   3H  0   0   2C,8G                                                                             5G  3C,7G                                                                             3C,6G                                                                             2C,3G                                                                             1H                 Sicklepod                                                                             4C,8G  --                                                             Nutsedge                                                                              2C,7G  4C,8G  3C,7G                                                                              3C,8G                                                                             0   0   2G  0   6G  0   4G  0                  Crabgrass                                                                             4G     2C,7G  3C,6G                                                                              2C  0   0   7G  0   4C,8G                                                                             2G  3C,7G                                                                             0                  Barnyardgrass                                                                         9H     6C,9H  9H   4C,9H                                                                             0   0   5C,9H                                                                             3C,8H                                                                             5C,9H                                                                             3H  3C,7H                                                                             0                  Wild Oats                                                                             4G     4C,9G  3C,7G                                                                              2C,5G                                                                             0   0   2C,3G                                                                             0   3C,3H                                                                             0   0   0                  Wheat   2G     3C,9G  8G   2C,8G                                                                             0   0   2C,9G                                                                             2G  2C,6G                                                                             0   2G  0                  Corn    2H     2C,9G  3C,9G                                                                              3C,9G                                                                             2G  0   4C,9G                                                                             9H  2C,8G                                                                             0   7H  0                  Soybean 5C,9G  4C,8H  4C,9G                                                                              5C,9G                                                                             4H  0   3C,8G                                                                             2H  3C,9G                                                                             2C  5C,9G                                                                             2C,4G              Rice    4G     4C,9G  5G   8G  0   0   5C,9G                                                                             2G  5C,9G                                                                             5G  4C,7G                                                                             0                  Sorghum 0      3C,9G  9H   4C,9H                                                                             1C  0   3C,8H                                                                             3C,3H                                                                             5C,9H                                                                             0   2C,3G                                                                             0                  Sugar beet                                                                            9C     9C     4C,9H                                                                              4C,8H                                                                             3C,6G                                                                             0   5C,9G                                                                             3C,8G                                                                             9C  3C,7H                                                                             5C,9H                                                                             3C,7G              Cotton  9C     10C    3C,7G                                                                              4C,7G                                                                             2C,5G                                                                             0   5C,9G                                                                             3C,5G                                                                             9C  3C,6G                                                                             4C,8H                                                                             2C,3G              Velvetleaf            4C,9G                                                                              8G  2C,6G                                                                             0   5C,9G                                                                             3C,7G                                                                             5C,9H                                                                             3C  4C,8H                                                                             2C                 Cheatgrass            9G   2C,8G                                                                             0   0   2C,6G                                                                             5G  4C,7G                                                                             2G  2C,2G                                                                             0                  PRE-EMERGENCE                                                                 Morningglory                                                                          9G     10C    8G   7G  3G  0   9G  6G  9G  8G  9C  7H                 Cocklebur                                                                             9G     8H     7G   7H  5G  0   3C,8H                                                                             5G  9H  5G  5G  2C                 Sicklepod                                                                             9C     --                                                             Nutsedge                                                                              3C,8G  9G     10E  0   0   0   0   0   5G  0   5G  0                  Crabgrass                                                                             5C,9G  4C,8G  7G   3G  2G  0   3C,7G                                                                             2C,5G                                                                             5C,8G                                                                             4C,8G                                                                             4C,8G                                                                             0                  Barnyardgrass                                                                         6C,9G  6C,9H  9H   9H  0   0   4C,9H                                                                             3G  5C,9H                                                                             2C,4G                                                                             3C,7H                                                                             0                  Wild Oats                                                                             9C     9C     5C,9G                                                                              3C,8G                                                                             0   0   5C,9G                                                                             3C,5G                                                                             5C,9H                                                                             3C,5G                                                                             4C,7G                                                                             2G                 Wheat   10C    5C,9H  3C,9G                                                                              8G  0   0   4C,8G                                                                             8G  10H 6G  3C,7H                                                                             0                  Corn    5C,9H  5C,9H  9H   9G  1C  0   4C,9H                                                                             4C,7H                                                                             10H 3C,9H                                                                             4C,8G                                                                             2C                 Soybean 4C,8G  4C,8H  4C,6H                                                                              3C,5G                                                                             0   0   3C,5G                                                                             0   4C,8H                                                                             3C,3H                                                                             4C,6H                                                                             2C                 Rice    5C,9H  10E    10E  9H  0   0   10E 7H  9H  3G  4C,9H                                                                             0                  Sorghum 5C,9H  5C,9H  4C,9H                                                                              3C,9G                                                                             0   0   4C,9H                                                                             3C,8G                                                                             4C,9H                                                                             3C,4H                                                                             4C,8H                                                                             2C,4G              Sugar beet                                                                            3C,9G  10E    5C,9G                                                                              4C,8G                                                                             5G  0   9C  3C,5G                                                                             9C  4C,8G                                                                             5C,9G                                                                             2C,8G              Cotton  2C,9G  4C,9G  2C,8G                                                                              3C,3H                                                                             2G  0   9G  2C,4G                                                                             4C,8G                                                                             2C,3G                                                                             5C,8G                                                                             2C,4G              Velvetleaf            4C,8G                                                                              3C,8G                                                                             4G  0   5C,8G                                                                             3C,3H                                                                             9C  4C,8H                                                                             9C  2C,5G              Cheatgrass            9H   8H  0   0   4C,8H                                                                             0   4C,9H                                                                             5G  4C,9G                                                                             2G                 __________________________________________________________________________                     Compound 8                                                                            Compound 9                                                                             Compound 10                                                                         Compound 11                                                                           Compound                                                                              Compound 13                    Rate kg/ha                                                                            0.4 0.05                                                                              0.4 0.05                                                                              0.4    0.4 0.05                                                                              0.4 0.05                                                                              0.02                  __________________________________________________________________________             POST-EMERGENCE                                                                Morningglory                                                                          5C,9H                                                                             2C,5G                                                                             3C,5G                                                                             3C,5G                                                                             2C,7H  10C 6C,9G                                                                             9C  5C,9G                                                                             4G                             Cocklebur                                                                             3C,5G                                                                             2H  2C,4G                                                                             0   1C,2G  9H  3C,7H                                                                             5C,9G                                                                             4G  2C                             Sicklepod                                                                     Nutsedge                                                                              3H  0   2G  0   2C,8G  10C 2C,5G                                                                             2C,5G                                                                             0   2G                             Crabgrass                                                                             4C,8G                                                                             2G  3C,4G                                                                             0   2C,5G  9C  3C,8G                                                                             5C,9G                                                                             3C,7G                                                                             0                              Barnyardgrass                                                                         4C,9H                                                                             0   2H  0   3C,9H  7C,9H                                                                             4C,9H                                                                             5C,9H                                                                             3C,8H                                                                             2H                             Wild Oats                                                                             0   0   0   0   3C,8G  9C  6C,9G                                                                             9C  4C,9G                                                                             0                              Wheat   0   0   0   0   3C,9G  5C,9G                                                                             9G  3C,9G                                                                             9G  0                              Corn    2C  0   0   0   3C,9H  5C,9G                                                                             5C,9H                                                                             3C,9H                                                                             3C,8H                                                                             1C,2G                          Soybean 5C,9G                                                                             2G  3C,3H                                                                             0   4C,9H  4C,9H                                                                             4C,8H                                                                             4C,9H                                                                             3C,6H                                                                             1H                             Rice    2C,5G                                                                             2G  3C,4G                                                                             4G  3C,9G  9C  5C,9G                                                                             9C  5C,9G                                                                             4C,8G                          Sorghum 2C,2H                                                                             0   2H  0   9H     4C,9G                                                                             4C,9H                                                                             5C,9H                                                                             4C,9H                                                                             2G                             Sugar beet                                                                            5C,9G                                                                             3C,6G                                                                             3C,6H                                                                             2H  4C,9H  10C 9C  9C  5C,9H                                                                             3C,8H                          Cotton  4C,8G                                                                             6G  3C,5G                                                                             3G  2C,5G  9C  9C  9C  4C,9H                                                                             3C,5H                          Velvetleaf                                                                            5C,9H                                                                             2C,2H                                                                             2C,3G                                                                             1C  2C,8G  10C 6C,9G                                                                             9C  2C,8G                                                                             3C,5H                          Cheatgrass                                                                            3C,7G                                                                             0   2C  0   7G     9C  5C,9G                                                                             5C,9G                                                                             3C,9G                                                                             2C                             PRE-EMERGENCE                                                                 Morningglory                                                                          9G  8G  9G  5G  9C     9H  4C,9G                                                                             9G  9G  2C,4G                          Cocklebur                                                                             9H  6H  7H  4G  9H     9H  9H  9H  5H  1H                             Sicklepod                                                                     Nutsedge                                                                              8G  2G  2C,5G                                                                             0   10E    4C,9G                                                                             5G  5G  0   0                              Crabgrass                                                                             4C,8G                                                                             3C,3G                                                                             3C,8G                                                                             5G  4C,9G  5C,9G                                                                             4C,9G                                                                             4C,9G                                                                             2C,5G                                                                             0                              Barnyardgrass                                                                         5C,9H                                                                             4C,8H                                                                             4C,8H                                                                             3G  2C,9G  5C,9H                                                                             4C,9H                                                                             4C,9H                                                                             2C  0                              Wild Oats                                                                             4C,9G                                                                             4C,6G                                                                             5C,9G                                                                             3C,3H                                                                             3C,9G  9C  6C,9G                                                                             6C,9G                                                                             3C,6G                                                                             0                              Wheat   5C,9H                                                                             2C,7G                                                                             5C,9H                                                                             4G  3C,9H  6C,9G                                                                             4C,9G                                                                             5C,9H                                                                             2C,6G                                                                             0                              Corn    5C,9H                                                                             4C,8H                                                                             4C,8H                                                                             3C,7H                                                                             3C,9G  3C,9G                                                                             4C,8H                                                                             4C,9H                                                                             3C,6G                                                                             0                              Soybean 3C,7H                                                                             3C,4G                                                                             4C,5G                                                                             2C,2H                                                                             3C,6G  6C,9G                                                                             3C,7H                                                                             3C,7H                                                                             3C,3H                                                                             2G                             Rice    10E 2C,6G                                                                             9H  7H  10E    10E 5C,9H                                                                             10E 3C,7G                                                                             2G                             Sorghum 6C,9H                                                                             3C,7H                                                                             5C,9H                                                                             3C  2C,9G  5C,9H                                                                             4C,9H                                                                             5C,9H                                                                             3C,6G                                                                             2C                             Sugar beet                                                                            5C,9G                                                                             4C,8G                                                                             5C,9G                                                                             3C,7G                                                                             5C,9G  9C  5C,9G                                                                             5C,9G                                                                             3C,7H                                                                             5G                             Cotton  3C,7H                                                                             2C,5G                                                                             3C,7G                                                                             2C  4G     9G  4C,8G                                                                             4C,9G                                                                             2C  1C                             Velvetleaf                                                                            9C  3C,8H                                                                             5C,9G                                                                             2C,4G                                                                             5C,9G  9C  9C  9C  4C,6H                                                                             0                              Cheatgrass                                                                            4C,9H                                                                             4C,8G                                                                             5C,9H                                                                             5G  6C,9H  10H 5C,9H                                                                             5C,9H                                                                             2C,6G                                                                             0                     __________________________________________________________________________

What is claimed is:
 1. A compound of the formula: ##STR36## wherein R isH or CH₃ ;G is O or NR₁ ; R₁ is H, C₁ to C₃ alkyl, CF₂ H, C₂ to C₃ alkylsubstituted with 1 to 3 atoms of F, CH₂ CH₂ OCH₃, CH₂ CH₂ OH, CH₂ CH₂OSi(CH₃)₃, (OH, OSi(CH₃)₃, C₁ to C₂ alkoxy, SO₂ CH₃, phenyl or benzyl;##STR37## R₂ is C₁ to C₄ alkyl, C₁ to C₄ alkoxy, OCH₂ CH₂ OCH₃, F, Cl,Br, C₁ to C₂ haloalkoxy, C₁ to C₂ haloalkylthio, C₁ to C₂haloalkylsulfonyl, C₂ to C₃ alkylcarbonyl, NO₂, CO₂ R₁₇, SO₂ NR₁₈ R₁₉,SO₂ N(OCH₃)CH₃, OSO₂ R₂₀, S(O)_(p) R₂₁, C₃ to C₄ alkenyloxy, C₃ to C₄alkynyloxy, C₁ to C₂ alkyl substituted with OCH₃, OCH₂ CH₃, 1 to 3 atomsof F or Cl, or with 1Br, C₂ to C₃ alkenyl optionally substituted with 1to 3F or Cl, C₆ H₅, ##STR38## R₃ is H, F, Cl, Br, CF₃, CH₃, CH₂ CH₃,OCH₃, OCF₂ H, OC₂ H₅, C₁ to C₂ alkylthio, CH₂ SCH₃, CH₂ OCH₃ or C₁ to C₂alkoxy substituted with 1 to 3F; R₄ is H, CH₃, OCH₃, F, Cl, Br, SO₂N(CH₃)₂, OSO₂ CH₃ or SO₂ CH₃ ; R₅ is CH₃, CH₂ CH₃, OCH₃, OCH₂ CH₃, F,Cl, Br, SO₂ NR₁₈ R₁₉, SO₂ N(OCH₃)CH₃ or SO₂ R₂₁ ; R₆ is F, Cl, Br, NO₂,CO₂ R₁₇, SO₂ NR₁₈ R₁₉, SO₂ N(OCH₃)CH₃ or SO₂ R₂₁ ; R₇ is H or C₁ to C₄alkyl; R₈ is H or CH₃ ; R₉ is H or CH₃ ; R₁₀ is H or C₁ to C₄ alkyl; R₁₁is H or CH₃ ; R₁₂ is H, C₁ to C₆ alkyl, C₂ to C₃ alkoxycarbonyl, C₂ toC₃ alkylcarbonyl or C₂ to C₄ alkyl substituted with Cl, Br, OCH₃ or OC₂H₅, or with 1 to 3F; R₁₃ is H or C₁ to C₃ alkyl; R₁₄ is H or CH₃ ; R₁₅is H or C₁ to C₃ alkyl; R₁₆ is C₁ to C₃ alkyl, F, Cl, Br, NO₂, CO₂ R₁₇,SO₂ NR₁₈ R₁₉, SO₂ N(OCH₃)CH₃, SO₂ R₂₁ or OCF₂ H; R₁₇ is C₁ to C₄ alkyl,CH₂ CH₂ OCH₃, CH₂ CH₂ Cl or CH₂ CH═CH₂ ; R₁₈ is C₁ to C₃ alkyl; R₁₉ isC₁ to C₃ alkyl; R₂₀ is C₁ to C₃ alkyl or N(CH₃)₂ ; R₂₁ is C₁ to C₃ alkylor CH₂ CH═CH₂ ; m is 0 or 1; p is 0, 1 or 2; Q₁ is O or SO₂ ; Q₂ is O orS; ##STR39## X is CH₃, OCH₃, OCH₂ CH₃, Cl, F, Br, I, OCF₂ H, CH₂ F, OCH₂CH₂ F, OCH₂ CHF₂, OCH₂ CF₃ or CF₃ ; Y is H, CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃,CH₂ OCH₂ CH₃, NHCH₃, N(COH₃)CH₃, N(CH₃)₂, C₂ H₅, CF₃, SCH₃, OCH₂C.tbd.CH, amino, CH₂ S(O)CH₃, CH₂ SO₂ CH₃, C.tbd.CH, C.tbd.CCH₃, OCH₂CH═CH₂, OCH₂ CH₂ OCH₃, CH₂ SCH₃, ##STR40## SCF₂ H or cyclopropyl; n is 2or 3; Q₃ and Q₄ are independently O or S; Q₅ is O or NR₂₅ ; R₂₂ is H orCH₃ ; R₂₃ and R₂₄ are independently C₁ to C₂ alkyl; R₂₅ is H or C₁ to C₃alkyl; R₂₆ is H or Cl; R₂₇ is H or Cl; R₂₈ is H or CH₃ ; Z is CH or N inA-7 and CH in A-1; Y₁ is O or CH₂ ; X₁ is H, CH₃ or OCH₃ ; Y₂ is H orCH₃ ; X₂ is CH₃, C₂ H₅ or CH₅ CF₃ ; Y₃ is OCH₃, OC₂ H₅, SCH₃, SC₂ H_(5L), OCF₂ H, SCF₂ H, CH₃ or C₂ H₅ ; Y₄ is CH₃, OC₂ H₅, OCH₃ or Cl; and X₄is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃ or Cl;and their agriculturally suitablesalts; provided that (a) when X is Cl, F, Br or I, then Y is OCH₃, OC₂H₅, N(OCH₃)CH₃, NHCH₃, N(CH₃)₂, OCF₂ H or amino; (b) when m is 1, thenR₉ is H; (c) the total number of carbon atoms of R₁₈ and R₁₉ does notexceed four; (d) when L is L-15, then R₁₃ and R₁₄ are not simultaneouslyH; (e) when L is L-16, then R16 is adjacent to the substituent ##STR41##and (f) when the total number of carbon atoms of X and Y is greater thanfour, then R₁ is H or CH₃ and the total number of carbons of thesubstituents on L does not exceed four.
 2. A compound according to claim1 wherein G is O and R is H.
 3. A compound according to claim 2 whereinY is CH₃, OCH₃, CH₂ OCH₃, C₂ H₅, NHCH₃, cyclopropyl or CH(OCH₃)₂, and R₁is H, C₁ to C₂ alkyl, CH₂ CF₃ or CF₂ H.
 4. A compound according to claim3 whereinR₂ is C₁ to C₃ alkyl, C₁ to C₃ alkoxy, Cl, Br, NO₂, CF₃, CO₂R₁₇, SO₂ N(CH₃)₂, OSO₂ R₂₀, SO₂ R₂₁, OCHF₂, ##STR42## R₃ is H, Cl, CH₃or OCH₃ ; R₄ is CH₃, OCH₃, Cl, Br, OSO₂ CH₃ or SO₂ CH₃ ; R₅ is Cl, SO₃N(CH₃)₂ or SO₂ CH₃ ; R₆ is Cl, NO₂, CO₂ R₁₇, SO₂ N(CH₃)₂ or SO₂ R₂₁ ; R₇is H or CH₃ ; R₉ is H; R₁₀ is H or CH₃ ; R₁₁ is H; R₁₂ is H or C₁ to C₄alkyl; R₁₃ is H or CH₃ ; R₁₅ is CH₃ ; R₁₆ is C₁ to C₂ alkyl, Cl, Br,NO₂, CO₂ CH₃, SO₂ N(CH₃)₂, SO₂ R₂₁ or OCF₂ H; R₁₇ is C₁ to C₃ alkyl; R₂₀is C₁ to C₃ alkyl; R₂₁ is C₁ to C₂ alkyl; R₂₅ is H or CH₃ ; R₂₈ is H; Q₂is O; A is A-1; and X is CH₃, OCH₃, OC₂ H₅, Cl, OCF₂ H or OCH₂ CF₃.
 5. Acompound according to claim 4 wherein L is L-1 and R₂ is CH₃, C₂ H₅,CF₃, Br, Cl or SO₂ R₂₁.
 6. A compound according to claim 4 wherein L isL-5 and R₆ is Cl or SO₂ R₂₁.
 7. A compound according to claim 4 whereinL is L-7.
 8. A compound according to claim 4 wherein L is L-9.
 9. Acompound according to claim 4 wherein L is L-10.
 10. A compoundaccording to claim 4 wherein L is L-15.
 11. A compound according toclaim 4 wherein L is L-16 and R₁₆ is C₁ to C₂ alkyl, Cl, Br or SO₂ R₂₁.12. A compound according to claim 1 wherein G is NR₁, R is H, and R₁ isH, C₁ to C₂ alkyl, CH₂ CF₃ or CF₂ H.
 13. A compound according to claim12 whereinL is L-1, L-5, L-7, L-9, L-10, L-15 or L-16; R₂ is C₁ to C₃alkyl, C₁ to C₃ alkoxy, Cl, Br, NO₂, CF₃, CO₂ R₁₇, SO₂ N(CH₃)₂, OSO₂R₂₀, SO₂ R₂₁, OCHF₂, ##STR43## R₃ is H, Cl, CH₃ or OCH₃ ; R₄ is CH₃,OCH₃, Cl, Br, OSO₂ CH₃ or SO₂ CH₃ ; R₅ is Cl, SO₂ N(CH₃)₂ or SO₂ CH₃ ;R₆ is Cl, NO₂, CO₂ R₁₇, SO₂ N(CH₃)₂ or SO₂ R₂₁ ; R₇ is H or CH₃ ; R₉ isH; R₁₀ is H or CH₃ ; R₁₁ is H; R₁₂ is H or C₁ to C₄ alkyl; R₁₃ is H orCH₃ ; R₁₅ is CH₃ ; R₁₆ is C₁ to C₂ alkyl, Cl, Br, NO₂, CO₂ CH₃, SO₂N(CH₃)₂, SO₂ R₂₁ or OCF₂ H; R₁₇ is C₁ to C₃ alkyl; R₂₀ is C₁ to C₃alkyl; R₂₁ is C₁ to C₂ alkyl; R₂₅ is H or CH₃ ; R₂₈ is H; Q₂ is O; A isA-1; and X is CH₃, OCH₃, OC₂ H₅, Cl, OCF₂ H or OCH₂ CF₃.
 14. A compound,2-bromo-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-N'-methylbenzenesulfonimide.15. A compoundN-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(methylsulfonyl)benzenesulfonimidamide.16. A composition for the control of undesirable vegetation consistingessentially of a compound of claim 1 and at least one of (a) a surfaceactive agent, and (b) a solid or liquid diluent.
 17. A composition forthe control of undesirable vegetation consisting essentially of acompound of claim 2 and at least one of (a) a surface active agent, and(b) a solid or liquid diluent.
 18. A composition for the control ofundesirable vegetation consisting essentially of a compound of claim 3and at least one of (a) a surface active agent, and (b) a solid orliquid diluent.
 19. A composition for the control of undesirablevegetation consisting essentially of a compound of claim 4 and at leastone of (a) a surface active agent, and (b) a solid or liquid diluent.20. A composition for the control of undesirable vegetation consistingessentially of a compound of claim 5 and at least one of (a) a surfaceactive agent, and (b) a solid or liquid diluent.
 21. A composition forthe control of undesirable vegetation consisting essentially of acompound of claim 6 and at least one of (a) a surface active agent, and(b) a solid or liquid diluent.
 22. A composition for the control ofundesirable vegetation consisting essentially of a compound of claim 7and at least one of (a) a surface active agent, and (b) a solid orliquid diluent.
 23. A composition for the control of undesirablevegetation consisting essentially of a compound of claim 8 and at leastone of (a) a surface active agent, and (b) a solid or liquid diluent.24. A composition for the control of undesirable vegetation consistingessentially of a compound of claim 9 and at least one of (a) a surfaceactive agent, and (b) a solid or liquid diluent.
 25. A composition forthe control of undesirable vegetation consisting essentially of acompound of claim 10 and at least one of (a) a surface active agent, and(b) a solid or liquid diluent.
 26. A composition for the control ofundesirable vegetation consisting essentially of a compound of claim 11and at least one of (a) a surface active agent, and (b) a solid orliquid diluent.
 27. A composition for the control of undesirablevegetation consisting essentially of a compound of claim 12 and at leastone of (a) a surface active agent, and (b) a solid or liquid diluent.28. A composition for the control of undesirable vegetation consistingessentially of a compound of claim 13 and at least one of (a) a surfaceactive agent, and (b) a solid or liquid diluent.
 29. A composition forthe control of undesirable vegetation consisting essentially of acompound of claim 14 and at least one of (a) a surface active agent, and(b) a solid or liquid diluent.
 30. A composition for the control ofundesirable vegetation consisting essentially of a compound of claim 15and at least one of (a) a surface active agent, and (b) a solid orliquid diluent.
 31. A method for the control of undesirable vegetationcomprising applying to the locus of such vegetation an herbicidallyeffective amount of a compound of claim
 1. 32. A method for the controlof undesirable vegetation comprising applying to the locus of suchvegetation an herbicidally effective amount of a compound of claim 2.33. A method for the control of undesirable vegetation comprisingapplying to the locus of such vegetation an herbicidally effectiveamount of a compound of claim
 3. 34. A method for the control ofundesirable vegetation comprising applying to the locus of suchvegetation an herbicidally effective amount of a compound of claim 4.35. A method for the control of undesirable vegetation comprisingapplying to the locus of such vegetation an herbicidally effectiveamount of a compound of claim
 5. 36. A method for the control ofundesirable vegetation comprising applying to the locus of suchvegetation an herbicidally effective amount of a compound of claim 6.37. A method for the control of undesirable vegetation comprisingapplying to the locus of such vegetation an herbicidally effectiveamount of a compound of claim
 7. 38. A method for the control ofundesirable vegetation comprising applying to the locus of suchvegetation an herbicidally effective amount of a compound of claim 8.39. A method for the control of undesirable vegetation comprisingapplying to the locus of such vegetation an herbicidally effectiveamount of a compound of claim
 9. 40. A method for the control ofundesirable vegetation comprising applying to the locus of suchvegetation an herbicidally effective amount of a compound of claim 10.41. A method for the control of undesirable vegetation comprisingapplying to the locus of such vegetation an herbicidally effectiveamount of a compound of claim
 11. 42. A method for the control ofundesirable vegetation comprising applying to the locus of suchvegetation an herbicidally effective amount of a compound of claim 12.43. A method for the control of undesirable vegetation comprisingapplying to the locus of such vegetation an herbicidally effectiveamount of a compound of claim
 13. 44. A method for the control ofundesirable vegetation comprising applying to the locus of suchvegetation an herbicidally effective amount of a compound of claim 14.45. A method for the control of undesirable vegetation comprisingapplying to the locus of such vegetation an herbicidally effectiveamount of a compound of claim 15.